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woensdag 7 maart 2018

Nature Immunology Contents: March 2018 Volume 19 Issue 3

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Nature Immunology

Visualize and Quantify Cellular Interactions in the Tumor Microenvironment

What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics™ research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs. 

Download eBook

March 2018 Volume 19, Issue 3

Research Highlights
News & Views
Review Articles

npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.
Explore the benefits of submitting your manuscript.


Frontiers in Cancer Immunotherapy 
April 26-27, 2018, NYC

Keynote speakers Jeffrey Ravetch of The Rockefeller University and Miriam Merad of Mount Sinai School of Medicine join other top experts in oncology and immunology to discuss emerging approaches and challenges faced in this rapidly evolving field.
Abstract deadline: Feb. 23rd.

Find more information and register here >> 

Poster on: CAR T cells in cancer therapy

Nature Reviews Drug Discovery present this Poster which provides an overview of the different ways to design and produce CAR T cells and the journey that has driven these CAR T cells to FDA approval in 2017.

Available to download free online

Produced with support from:
Lonza Bioscience Solutions



Capturing resting T cells: the perils of PLL    pp203 - 205
Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A. Fernandes, Jorge Bernardino de la Serna et al.

Research Highlights


HLA influence on HIV control    p206
Laurie A. Dempsey

Mitochondrial DNA webs    p206
Zoltan Fehervari

Inflammatory brain ripples    p206
Zoltan Fehervari

B-1a cell metabolism    p206
Laurie A. Dempsey

Tumor architecture    p206
Ioana Visan

Alu element risk    p206
Ioana Visan

News & Views


The origins of diversity in human immunity    pp209 - 210
Adrian Liston & An Goris

Cancer cells deliver a suppressive cargo    pp207 - 208
Akinori Takaoka

Hoxb5, a Trojan horse to generate T cells    pp210 - 212
Gregoire Stik & Thomas Graf

JOBS of the week
Faculty Member â€" Cryo-EM
St. Jude Children's Research Hospital (SJCRH)
Postdoctoral Fellow
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Director / Senior Director, Immuno-Oncology Research
Alector LLC
Postdoctoral Fellow Position Available
National Institutes of Health (NIH), Department of Health and Human Services (HHS)
Postdoctoral Scientist (m / f) Cancer Immunology
Boehringer Ingelheim
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New York, USA
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Review Articles


Metabolic exhaustion in infection, cancer and autoimmunity    pp213 - 221
E. F. McKinney & K. G. C. Smith

McKinney and Smith review the metabolic exhaustion of T cells in infection, cancer and autoimmunity


The immunology of hepatocellular carcinoma    pp222 - 232


Primary liver cancer, of which hepatocellular carcinoma is the most common form, is the second leading cause of cancer-related death. Heikenwalder and colleagues review the important inflammatory component underlying hepatocellular carcinoma and consider potential directions for therapy.


Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

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Tumor-derived exosomes antagonize innate antiviral immunity    pp233 - 245
Liang Gao, Lin Wang, Tong Dai, Ke Jin, Zhengkui Zhang et al.

Cancer can be associated with alterations in innate immunity. Gao et al. demonstrate that these alterations arise from immunomodulatory exosomes released by tumors, which then dampen the production of type I interferons by macrophages.


Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling    pp246 - 254
Mohammad Samie, Junghyun Lim, Erik Verschueren, Joshua M. Baughman, Ivan Peng et al.

Polymorphisms in the autophagy protein Atg16l are associated with human inflammatory bowel disease. Murthy and colleagues demonstrate that atg16l is crucial to autophagocytic degradation of the innate adapter TRIF and thereby restrains pathological over-production of type I interferons.


Toll-like receptor 9 antagonizes antibody affinity maturation    pp255 - 266
Munir Akkaya, Billur Akkaya, Ann S. Kim, Pietro Miozzo, Haewon Sohn et al.

The presentation of antigen by germinal-center B cells to follicular T cells engenders the process of antibody affinity maturation and humoral memory. Pierce and colleagues show that TLR9 signaling in B cells antagonizes B cellâ€"mediated antigen presentation, which leads to the enhanced generation of short-lived plasma cells and the production of lower-affinity antibodies.


The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers    pp267 - 278
Elisa Monzón-Casanova, Michael Screen, Manuel D. Díaz-Muñoz, Richard M. R. Coulson, Sarah E. Bell et al.

Affinity maturation and positive selection occur in germinal centers. Turner and colleagues demonstrate that the RNA-binding protein PTBP1 serves an essential B cellâ€"intrinsic role by regulating the abundance and alternate splicing of transcripts in germinal center B cells.


Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes    pp279 - 290
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao et al.

Wang and colleagues show that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is absent from committed B cells and T cells, can reprogram pro-pre-B cells into functional early T cell lineage progenitors.


Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR    pp291 - 301
David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M. Klein, Diane Mathis et al.

Regulatory T (Treg) cells have distinct transcriptional programs underpinning their suppressive functions. Benoist and colleagues use single-cell RNA-seq to describe the transcriptional landscape of Treg cells and the effects of T cellâ€"receptor signaling.


Animation on CRISPR: Gene editing and beyond 

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next.

Watch the Animation >> 

Produced with support from: 



Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors    pp302 - 314
Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri et al.

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.


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