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woensdag 7 maart 2018

Nature Immunology Contents: March 2018 Volume 19 Issue 3

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Nature Immunology

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TABLE OF CONTENTS

March 2018 Volume 19, Issue 3

Correspondence
Research Highlights
News & Views
Review Articles
Articles
Resources
 
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Correspondence

 

Capturing resting T cells: the perils of PLL    pp203 - 205
Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A. Fernandes, Jorge Bernardino de la Serna et al.
doi:10.1038/s41590-018-0048-8

Research Highlights

 

HLA influence on HIV control    p206
Laurie A. Dempsey
doi:10.1038/s41590-018-0057-7

Mitochondrial DNA webs    p206
Zoltan Fehervari
doi:10.1038/s41590-018-0058-6

Inflammatory brain ripples    p206
Zoltan Fehervari
doi:10.1038/s41590-018-0059-5

B-1a cell metabolism    p206
Laurie A. Dempsey
doi:10.1038/s41590-018-0060-z

Tumor architecture    p206
Ioana Visan
doi:10.1038/s41590-018-0061-y

Alu element risk    p206
Ioana Visan
doi:10.1038/s41590-018-0062-x

News & Views

 

The origins of diversity in human immunity    pp209 - 210
Adrian Liston & An Goris
doi:10.1038/s41590-018-0047-9

Cancer cells deliver a suppressive cargo    pp207 - 208
Akinori Takaoka
doi:10.1038/s41590-018-0050-1

Hoxb5, a Trojan horse to generate T cells    pp210 - 212
Gregoire Stik & Thomas Graf
doi:10.1038/s41590-018-0053-y

Immunology
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Director / Senior Director, Immuno-Oncology Research
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Postdoctoral Scientist (m / f) Cancer Immunology
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Review Articles

 

Metabolic exhaustion in infection, cancer and autoimmunity    pp213 - 221
E. F. McKinney & K. G. C. Smith
doi:10.1038/s41590-018-0045-y

McKinney and Smith review the metabolic exhaustion of T cells in infection, cancer and autoimmunity

 

The immunology of hepatocellular carcinoma    pp222 - 232

doi:10.1038/s41590-018-0044-z

Primary liver cancer, of which hepatocellular carcinoma is the most common form, is the second leading cause of cancer-related death. Heikenwalder and colleagues review the important inflammatory component underlying hepatocellular carcinoma and consider potential directions for therapy.

 

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Articles

 

Tumor-derived exosomes antagonize innate antiviral immunity    pp233 - 245
Liang Gao, Lin Wang, Tong Dai, Ke Jin, Zhengkui Zhang et al.
doi:10.1038/s41590-017-0043-5

Cancer can be associated with alterations in innate immunity. Gao et al. demonstrate that these alterations arise from immunomodulatory exosomes released by tumors, which then dampen the production of type I interferons by macrophages.

 

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling    pp246 - 254
Mohammad Samie, Junghyun Lim, Erik Verschueren, Joshua M. Baughman, Ivan Peng et al.
doi:10.1038/s41590-017-0042-6

Polymorphisms in the autophagy protein Atg16l are associated with human inflammatory bowel disease. Murthy and colleagues demonstrate that atg16l is crucial to autophagocytic degradation of the innate adapter TRIF and thereby restrains pathological over-production of type I interferons.

 

Toll-like receptor 9 antagonizes antibody affinity maturation    pp255 - 266
Munir Akkaya, Billur Akkaya, Ann S. Kim, Pietro Miozzo, Haewon Sohn et al.
doi:10.1038/s41590-018-0052-z

The presentation of antigen by germinal-center B cells to follicular T cells engenders the process of antibody affinity maturation and humoral memory. Pierce and colleagues show that TLR9 signaling in B cells antagonizes B cellâ€"mediated antigen presentation, which leads to the enhanced generation of short-lived plasma cells and the production of lower-affinity antibodies.

 

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers    pp267 - 278
Elisa Monzón-Casanova, Michael Screen, Manuel D. Díaz-Muñoz, Richard M. R. Coulson, Sarah E. Bell et al.
doi:10.1038/s41590-017-0035-5

Affinity maturation and positive selection occur in germinal centers. Turner and colleagues demonstrate that the RNA-binding protein PTBP1 serves an essential B cellâ€"intrinsic role by regulating the abundance and alternate splicing of transcripts in germinal center B cells.

 

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes    pp279 - 290
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao et al.
doi:10.1038/s41590-018-0046-x

Wang and colleagues show that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is absent from committed B cells and T cells, can reprogram pro-pre-B cells into functional early T cell lineage progenitors.

 

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR    pp291 - 301
David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M. Klein, Diane Mathis et al.
doi:10.1038/s41590-018-0051-0

Regulatory T (Treg) cells have distinct transcriptional programs underpinning their suppressive functions. Benoist and colleagues use single-cell RNA-seq to describe the transcriptional landscape of Treg cells and the effects of T cellâ€"receptor signaling.

 

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Resources

 

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors    pp302 - 314
Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri et al.
doi:10.1038/s41590-018-0049-7

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

 

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