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maandag 26 maart 2018

Nature Immunology Contents: April 2018 Volume 19 Issue 4

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Nature Immunology

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April 2018 Volume 19, Issue 4

Research Highlights
News & Views
Review Articles

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Alessandro Moretta 1953–2018    p315
Lorenzo Moretta & Alberto Mantovani

Research Highlights


Targeting TGF-β in cancer    p316
Ioana Visan

Establishing T cell lineage identity    p316
Ioana Visan

Neuroregulation of ILC2s    p316
Laurie A. Dempsey

Asymmetry in PI(3)K activity    p316
Laurie A. Dempsey

Mast cells in autoimmune disease    p316
Zoltan Fehervari

Flowing into higher dimensions    p316
Zoltan Fehervari

News & Views


Age-associated B cells acquire a new wrinkle    pp317 - 318
Yong-Rui Zou & Anne Davidson

IL-33 meets allergens at the gate    pp318 - 320
Dirk E. Smith

Training myeloid precursors with fungi, bacteria and chips    pp320 - 322
Manfred Kopf & Peter J. Nielsen

CD1c caves in on lipids    pp322 - 324
Dirk M. Zajonc

Is it dead or alive? TLR8 can tell    pp324 - 326
Stuart G. Tangye

JOBS of the week
Malaria Pathogenesis and Immunity Postdoctoral Scientist
National Institute of Allergy and Infectious Diseases
Executive Director, Brown Center for Immunotherapy
Indiana University School of Medicine
University Professor of Immunogerontology
University of Innsbruck
Postdoctoral Position - Immune Oncology
H. Lee Moffitt Cancer & Research Institute
Scientist I / II, Immunology
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Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease
Leesburg, USA
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Review Articles


Innate immune responses to trauma    pp327 - 341
Markus Huber-Lang, John D. Lambris & Peter A. Ward

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Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor    pp342 - 353
Lin Jin, Xiaomin Guo, Chuanbin Shen, Xue Hao, Peng Sun et al.

Mosquito salivary-gland extract can modulate the host immune response. Qi and colleagues show that the salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.


IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling    pp354 - 365
Tomasz Herjan, Lingzi Hong, Jodi Bubenik, Katarzyna Bulek, Wen Qian et al.

Act1 is an adaptor protein that associates with the IL-17 receptor at the cell membrane. Li and colleagues show that Act1 also exhibits unexpected RNA-binding activity and directly stabilizes select mRNAs encoding inflammatory cytokines and chemokines.


A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer    pp366 - 374
Emma L. Kuan & Steven F. Ziegler

Tumor cells commonly manipulate their environment to ensure their survival. Kuan and Ziegler show that breast cancer cells release IL-1α, which acts on infiltrating myeloid cells to elicit their production of TSLP. In turn, TSLP promotes the survival of TSLPR+ tumor cells by upregulating expression of the pro-survival factor Bcl-2.


Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33    pp375 - 385
Corinne Cayrol, Anais Duval, Pauline Schmitt, Stephane Roga, Mylène Camus et al.

The cytokine IL-33 has major roles in type 2 immunity and allergy. Girard and colleagues demonstrate that a broad range of allergens across multiple kingdoms can directly cleave IL-33 via their intrinsic protease activity and convert it into a highly active processed form.


Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses    pp386 - 396
Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg et al.

Sander and colleagues show that antigen-presenting cells detect bacterial RNA from live bacteria via TLR8 and promote TFH cell differentiation and vaccine responses through the induction of a specific cytokine profile.


T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids    pp397 - 406
Kwok S. Wun, Josephine F. Reijneveld, Tan-Yun Cheng, Kristin Ladell, Adam P. Uldrich et al.

CD1 molecules present diverse lipid ligands to TCRs expressed by NKT cells. Rossjohn, Moody and colleagues show a unique form of autoreactivity with human CD1c molecules, whereby TCRs recognize a closed conformation of CD1c molecules, which are loaded with a diverse array of ‘headless’ glycolipids.


Regulation of age-associated B cells by IRF5 in systemic autoimmunity    pp407 - 419
Michela Manni, Sanjay Gupta, Edd Ricker, Yurii Chinenov, Sung Ho Park et al.

A unique subset of T-bet-expressing B cells accumulates with aging and in autoimmunity. Pernis and colleagues show that dysregulation of the transcription factor IRF5 occurs after loss of the Rho GTPase–regulatory proteins DEF6 and SWAP-70 and leads to the premature generation of age-associated B cells.


Nature Collection: Gut-brain axis 

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