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dinsdag 6 maart 2018

Nature Biotechnology Contents: Volume 36 pp 205 - 286

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TABLE OF CONTENTS

March 2018 Volume 36, Issue 3

Editorial
News
Correction
Bioentrepreneur
Opinion and Comment
Feature
News and Views
Research
Careers and Recruitment

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Nature Spotlight on Nano Carbon Technology in Japan

- Catching up with carbon -

Japan's historical leadership in the field of nanocarbon research is being challenged. 

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Poster on: The expanding CRISPR toolbox

The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR. 

Available to download free online >> 

Produced with support from: 
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Editorial

Amazon's cloud on the healthcare horizon   p205
doi:10.1038/nbt.4107
A new venture from Amazon, JP Morgans and Berkshire Hathaway has US healthcare in its crosshairs. It may also offer opportunities for innovators in health IT and digital medicine.

News

Migraine drug race turns its final corner, FDA decisions in sight   pp207 - 208
Elie Dolgin
doi:10.1038/nbt0318-207

EPO revokes Broad's CRISPR patent   p209
Charlotte Harrison
doi:10.1038/nbt0318-209b

Jury out on liquid biopsies for cancer   pp209 - 210
Mark Ratner
doi:10.1038/nbt0318-209a

Preprint wipes millions off CRISPR companies' stocks   p211
Eva von Schaper
doi:10.1038/nbt0318-211

FDA makes drug data public   p212
doi:10.1038/nbt0318-212b

First off-the-shelf mesenchymal stem cell therapy nears European approval   pp212 - 214
Cormac Sheridan
doi:10.1038/nbt0318-212a

Correction

Correction   p214
doi:10.1038/nbt0318-214a

News

Around the world in a month   p214
doi:10.1038/nbt0318-214b

News Feature

Driving T-cell immunotherapy to solid tumors   pp215 - 219
Ken Garber
doi:10.1038/nbt.4090
T cell receptor (TCR) gene therapy can target the immune system to solid tumors in ways CAR-T cells can't match, but the field is still looking for a clear success. Ken Garber reports.

Benchtop Linear MALDI-TOF Mass Spec

Providing a dependable, robust, and easy-to-maintain platform, Shimadzu's new benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes. Intuitive software simplifies operation and enables 21 CFR Part 11 compliance.

Learn more
.

Bioentrepreneur

Building a Business

The alphabet soup of agreements   pp220 - 224
Sadhana Chitale, Colm Lawler and Scott Macfarlane
doi:10.1038/nbt.4088

Podcast

First Rounders podcast: Jeffrey Leiden   p224
doi:10.1038/nbt.4087

Countering Antimicrobial Resistance

This conference will highlight work on understanding the ecology and spread of infectious agents and innovations in screening, therapeutic modalities and new countermeasures to address the spread of organisms resistant to carbapenem or vancomycin as well as multidrug-resistant Mycobacterium tuberculosis.

May 28-29, 2018 | Beijing, China
 

Opinion and Comment

Correspondence

The NIEHS TaRGET II Consortium and environmental epigenomics   pp225 - 227
Ting Wang, Erica C Pehrsson, Deepak Purushotham, Daofeng Li, Xiaoyu Zhuo et al.
doi:10.1038/nbt.4099

Commentary

The evidence gap   pp228 - 232
Vicki Seyfert-Margolis
doi:10.1038/nbt.4097
Why digitally powered real-world evidence is the fix needed for our broken clinical trials system.

Feature

Patents

Recent patents in DNA sequencing   p233
doi:10.1038/nbt.4105

News and Views

Smart cancer therapy with DNA origami   pp234 - 235
Ennio Tasciotti
doi:10.1038/nbt.4095
Tumor infarction is achieved through targeted delivery of thrombin by DNA nanorobots.

See also: Research by Li et al.

An archive written in DNA   pp236 - 237
Reinhard Heckel
doi:10.1038/nbt.4093
New research sets a world record in the volume of data stored in and retrieved from DNA.

See also: Research by Organick et al.

Research Highlights   p237
doi:10.1038/nbt.4092

All MiNDS on the brain   p238
Irene Jarchum
doi:10.1038/nbt.4094

Biotechnology
JOBS of the week
Dean of the Faculty of Science
The Chinese University of Hong Kong
Associate Research Scientist
Columbia University
Postdoctoral Fellow
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Postdoctoral Research Associates – Computational Biology
St. Jude Children's Research Hospital (SJCRH)
Computational Scientist
Celgene CITRE
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Biotechnology
EVENT
International Biotechnology Conference
April 25, 2018
Rome, Italy
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Research

Brief Communications

Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity   pp239 - 241
Hui Kwon Kim, Seonwoo Min, Myungjae Song, Soobin Jung, Jae Woo Choi et al.
doi:10.1038/nbt.4061
Using deep learning to combine target sequence and chromatin accessibility data boosts the accuracy of CRISPR-Cpf1 guide RNA activity

Articles

Random access in large-scale DNA data storage   pp242 - 248
Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin et al.
doi:10.1038/nbt.4079
200 MB of digital data is stored in DNA, randomly accessed and recovered using an error-free approach.

See also: News and Views by Heckel

Sugar release and growth of biofuel crops are improved by downregulation of pectin biosynthesis   pp249 - 257
Ajaya K Biswal, Melani A Atmodjo, Mi Li, Holly L Baxter, Chang Geun Yoo et al.
doi:10.1038/nbt.4067
Engineered switchgrass and poplar are better feedstocks for biofuel synthesis and yield more biomass in multi-year field trials.

Letters

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo    pp258 - 264
Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian et al.
doi:10.1038/nbt.4071
DNA origami-based nanorobot presents thrombin to cause tumor infarction after specific recognition of a tumor vessel marker.

See also: News and Views by Tasciotti

A highly specific SpCas9 variant is identified by in vivo screening in yeast   pp265 - 271
Antonio Casini, Michele Olivieri, Gianluca Petris, Claudia Montagna, Giordano Reginato et al.
doi:10.1038/nbt.4066
Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity.

Resources

Recon3D enables a three-dimensional view of gene variation in human metabolism   pp272 - 281
Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Drager et al.
doi:10.1038/nbt.4072
Large-scale integration of metabolite and protein structural data with existing networks of human metabolism provides insights into gene function and how drugs affect metabolic response.

Careers and Recruitment

Evidence for a mental health crisis in graduate education   pp282 - 284
Teresa M Evans, Lindsay Bira, Jazmin Beltran Gastelum, L Todd Weiss and Nathan L Vanderford
doi:10.1038/nbt.4089
With mental illness a growing concern within graduate education, data from a new survey should prompt both academia and policy makers to consider intervention strategies.

People

People   p286
doi:10.1038/nbt.4100

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