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zaterdag 10 februari 2018

The Lancet: [Articles] Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum t...

[Articles] Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
Adding a single dose of 0·25 mg/kg primaquine to sulfadoxine-pyrimethamine and amodiaquine or 3 days of 15 mg/kg per day methylene blue to dihydroartemisinin-piperaquine was highly efficacious for preventing P falciparum transmission. Both primaquine and methylene blue were well tolerated.
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[Comment] Drugs that reduce transmission of falciparum malaria
Substantial gains have been made in reducing the global burden of malaria, much of which can be attributed to greater access to prompt diagnosis and highly effective treatment. However, as endemic countries commit to eliminating malaria, more aggressive interventions are needed to target the large number of apparently healthy individuals who harbour transmissible malaria parasites. Although most national antimalarial guidelines recommend artemisinin combination therapy for the management of uncomplicated falciparum malaria, chemopreventive strategies have generally adopted non-artemisinin combination therapy regimens such as sulfadoxine-pyrimethamine and amodiaquine.
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[Corrections] Corrections
Ladhani S N, Collins S, Djennad A, et al. Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000–17: a prospective national observational cohort study. Lancet Infect Dis 2018; published online Jan 25. http://dx.doi.org/10.1016/S1473-3099(18)30052-5—In figure 2 of the appendix, the panel incorrectly labelled ST7F should have been labelled ST9N. This correction has been made in the online version as of Feb 6, 2018.
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[Newsdesk] MSF challenges pneumococcal vaccine patent in India
Pfizer and GSK dominate pneumococcal vaccine manufacturing, but an impending court case in India could pave the way for others, which MSF hopes will drive down costs. Ann Danaiya Usher reports.
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[Media Watch] An anthropological view on the emerging threat of Zika virus
Since 2015, there has been a flood of both scientific and lay papers on Zika virus and the harm it might inflict on unborn children of infected mothers in the form of microcephaly and other severe brain defects. What we hear less about are the lives and experiences of the people at the centre of the epidemic that hit Brazil in September, 2015: a wave that started with mere rumours of babies born with small heads in the country's northeast region that rapidly snowballed into the formal declaration of a Public Health Emergency of International Concern by WHO in February, 2016.
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