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dinsdag 27 februari 2018

Nature Reviews Neurology - Table of Contents alert Volume 14 Issue 3

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Nature Reviews Neurology

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March 2018 Volume 14 Number 3
Nature Reviews Neurology cover
2016 2-year Impact Factor 20.257 Journal Metrics 2-year Median 15
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Melanie D. Sweeney, Abhay P. Sagare & Berislav V. Zlokovic


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Managing Neuropsychiatric Symptoms in Neurodegenerative Disease 
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Nature Collection: Gut-brain axis 

This Nature Collection brings together Research, Reviews and News from across the Nature Research journals and presents a selection of articles covering key aspects of the gut-brain axis including the gut microbiota and immune, neuroendocrine and neural factors. 

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Alzheimer disease: APOE ε4 affects cognitive decline but does not block benefits of healthy lifestyle<
Published online: 09 February 2018
p125 | doi:10.1038/nrneurol.2018.16


Sensory systems: Bimodal cochlear nucleus stimulation alleviates tinnitus
Published online: 19 January 2018
p126 | doi:10.1038/nrneurol.2018.1


Neurodegenerative disease: TDP pathology leads to nuclear disruption
Published online: 19 January 2018
p126 | doi:10.1038/nrneurol.2018.2


Stroke: Expanding the thrombectomy time window after stroke
Published online: 09 February 2018
p128 | doi:10.1038/nrneurol.2018.15


Neurodegenerative disease: Proteome points to synaptic dysfunction in dementia
Published online: 29 January 2018
p128 | doi:10.1038/nrneurol.2018.5




Parkinson disease: LRRK2 variants linked to PD and Crohn's disease | Demyelinating disease: Cholesterol crystals thwart repair in old CNS | Alzheimer disease: BACE1 inhibitors block new Aβ plaque formation | Traumatic brain injury: Minocycline reduces microglial activation but increases neurodegeneration after TBI | Stroke: Kv1.3 inhibition shows therapeutic potential in animal models of ischaemic stroke | Dementia: Peripheral inflammation could be a prodromal indicator of dementia

Nature Reviews Neurology
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Multiple sclerosis: Extracranial venous angioplasty is ineffective to treat MS
Robert Zivadinov & Bianca Weinstock-Guttman

Published online: 05 January 2018
p129 | doi:10.1038/nrneurol.2017.180

A randomized, double-blind, sham-controlled trial, Brave Dreams, has shown no clinical or radiological benefit of percutaneous transluminal angioplasty (PTA) to correct chronic cerebrospinal venous insufficiency in patients with multiple sclerosis (MS). These results finally settle the scientific debate over whether PTA can improve clinical, radiological and symptomatic outcomes in this patient population.
Full Text | PDF

Peripheral neuropathies: Subcutaneous immunoglobulin — the future of CIDP treatment?
Benjamin R. Wakerley & Nobuhiro Yuki

Published online: 12 January 2018
p130 | doi:10.1038/nrneurol.2017.179

Results from the PATH study indicate that subcutaneous immunoglobulin is efficacious and well tolerated for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (CIDP). This finding represents an important step in the management of patients with immunoglobulin-responsive CIDP, with considerable implications for the cost of treatment and, most importantly, for these patients' quality of life.
Full Text | PDF

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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Melanie D. Sweeney, Abhay P. Sagare & Berislav V. Zlokovic

Published online: 29 January 2018
p133 | doi:10.1038/nrneurol.2017.188

Here, Sweeney and colleagues focus on advanced neuroimaging evidence of blood-brain barrier (BBB) breakdown in several neurodegenerative disorders. The role of the ageing cerebrovascular system in neurodegeneration and dementia and the implications of BBB dysfunction for treatment and drug delivery are also discussed.
Abstract | Full Text | PDF

Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction
Heinz Jungbluth, Susan Treves, Francesco Zorzato, Anna Sarkozy, Julien Ochala, Caroline Sewry, Rahul Phadke, Mathias Gautel & Francesco Muntoni

Published online: 02 February 2018
p151 | doi:10.1038/nrneurol.2017.191

The congenital myopathies are a group of early-onset neuromuscular disorders characterized by muscle weakness and distinctive structural abnormalities in skeletal muscle. In this Review, the authors summarize the genetic, clinical and pathological features of the main congenital myopathies and discuss current and future approaches to treatment and management.
Abstract | Full Text | PDF

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Steven E. Arnold, Zoe Arvanitakis, Shannon L. Macauley-Rambach, Aaron M. Koenig, Hoau-Yan Wang, Rexford S. Ahima, Suzanne Craft, Sam Gandy, Christoph Buettner, Luke E. Stoeckel, David M. Holtzman & David M. Nathan

Published online: 29 January 2018
p168 | doi:10.1038/nrneurol.2017.185

Alzheimer disease (AD) and related dementias share numerous mechanistic and epidemiological similarities with type 2 diabetes mellitus (T2DM). However, whether these associations result from synergistic interactions between the disorders is unclear. This Review summarizes our current knowledge regarding insulin signalling and resistance in the brain and discusses current evidence concerning neurological impairment in T2DM and insulin resistance in AD.
Abstract | Full Text | PDF

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Neurological disorders of gait, balance and posture: a sign-based approach
Jorik Nonnekes, Rianne J. M. Goselink, Evžen Růžička, Alfonso Fasano, John G. Nutt & Bastiaan R. Bloem

Published online: 29 January 2018
p183 | doi:10.1038/nrneurol.2017.178

In this article, Nonnekes and colleagues offer a new approach to the diagnosis of neurological disorders associated with altered gait, balance and posture. Their method takes the presenting sign or signs as the starting point of a focused differential diagnosis, which triggers a tailored search into the underlying neurological syndrome.
Abstract | Full Text | PDF | Supplementary information

Nature Reviews Cardiology: Prevention of cardiovascular disease

This Series by Nature Reviews Cardiology features articles on the latest advances in the field of primary prevention of cardiovascular disease, from lifestyle modification strategies to clinical interventions targeting cardiovascular risk factors.

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Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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