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woensdag 14 februari 2018

Nature Reviews Genetics Contents March 2018 Volume 19 Number 3 pp 125-185

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TABLE OF CONTENTS
 
March 2018 Volume 19 Number 3 Advertisement
 
Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights
Reviews
Perspectives
Correspondence

 
Also this month
Article series:
Epigenetics
Disease mechanisms
Translational genetics
 Featured article:
Prioritizing diversity in human genomics research
Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio & Eric D. Green

 
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Poster on: The expanding CRISPR toolbox

The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR. 

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RESEARCH HIGHLIGHTS
 
Top

Genomics: Next regeneration sequencing for reference genomes
p125 | doi:10.1038/nrg.2018.5
PDF


Functional genomics: A drop in an ocean of gene variants
p126 | doi:10.1038/nrg.2018.1
PDF


Technique: SNP-CLINGing onto your post in the genome
p126 | doi:10.1038/nrg.2018.2
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Plant genetics: Parasites plant microRNAs in the host
p127 | doi:10.1038/nrg.2018.3
PDF


 

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Nature Collection: 2017 Nobel Prize in Physiology or Medicine

The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm. 

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REVIEWS
 
Top
Article series: Epigenetics
Statistical and integrative system-level analysis of DNA methylation data
Andrew E. Teschendorff & Caroline L. Relton

p129 | doi:10.1038/nrg.2017.86
The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data.
Abstract | Full Text | PDF

 
The new genetics of intelligence
Robert Plomin & Sophie von Stumm

p148 | doi:10.1038/nrg.2017.104
Recent genome-wide association studies have catapulted the search for genes underlying human intelligence into a new era. Genome-wide polygenic scores promise to transform research on individual differences in intelligence, but not without societal and ethical implications, as the authors discuss in this Review.
Abstract | Full Text | PDF

 
Article series: Disease mechanisms
Nuclear receptors in cancer — uncovering new and evolving roles through genomic analysis
Vineet K. Dhiman, Michael J. Bolt & Kevin P. White

p160 | doi:10.1038/nrg.2017.102
Genomic technologies are providing a clearer picture of how nuclear receptors (NRs) regulate complex transcriptional networks and contribute to the development and progression of cancer. This deeper understanding of NRs will hopefully lead to improved prognostic tools and new therapeutic targets.
Abstract | Full Text | PDF

 
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Springer Nature presents a custom webcast on: Precision over Bulk: Opportunities for Single-Cell DNA Analysis in Oncology

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PERSPECTIVES
 
Top
SCIENCE AND SOCIETY
Article series: Translational genetics
Prioritizing diversity in human genomics research
Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio & Eric D. Green

p175 | doi:10.1038/nrg.2017.89
Including diverse populations in genomic studies has the potential to improve the use of genomic data in the clinic. Here, members of the National Human Genome Research Institute review the benefits of increasing diversity, the challenges to overcome and key recommendations for how to achieve this goal.
Abstract | Full Text | PDF

 
 
CORRESPONDENCE
 
Top
Using partitioned heritability methods to explore genetic architecture
Luke M. Evans & Matthew C. Keller

p185 | doi:10.1038/nrg.2018.6
Full Text | PDF
 
Heritable contributions versus genetic architecture
Nicholas J. Timpson, Celia M. T. Greenwood, Nicole Soranzo, Daniel J. Lawson & J. Brent Richards

p185 | doi:10.1038/nrg.2018.7
Full Text | PDF
 
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