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Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 15 Issue 3

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Nature Reviews Gastroenterology & Hepatology

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In this issue
Research Highlights
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Also this month
 Featured article:
Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
Chun-Ming Wong, Felice Ho-Ching Tsang & Irene Oi-Lin Ng

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Nature Outlook: Fatty liver disease 

The worldwide rise in obesity and diabetes has led to a spike in non-alcoholic fatty liver disease, which often progresses to the more severe non-alcoholic steatohepatitis. This Outlook discusses new diagnostic techniques and therapies. 

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Colorectal cancer: Bacterial biofilms and toxins prompt a perfect storm for colon cancer
Published online: 23 February 2018
p129 | doi:10.1038/nrgastro.2018.16


Pancreatic cancer: KRAS dosage key in PDAC
Published online: 07 February 2018
p130 | doi:10.1038/nrgastro.2018.12


Liver: A protective role for TREM2 in liver injury
Published online: 14 February 2018
p130 | doi:10.1038/nrgastro.2018.13


Diagnosis: Gas-sensing gut capsules
Published online: 17 January 2018
p130 | doi:10.1038/nrgastro.2018.3


Diagnosis: Biomarkers and balloons for the detection of Barrett oesophagus
Published online: 07 February 2018
p131 | doi:10.1038/nrgastro.2018.9


Gut microbiota: Targeting of specific microbial species mitigates colitis
Published online: 17 January 2018
p132 | doi:10.1038/nrgastro.2018.4


Viral hepatitis: Biomarker for HBV therapy discontinuation
Published online: 24 January 2018
p132 | doi:10.1038/nrgastro.2018.6



Nature Reviews Gastroenterology & Hepatology
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Colorectal cancer: Hand-in-hand — colorectal cancer metastasizes with microorganisms
Ye Yang & Christian Jobin

Published online: 17 January 2018
p133 | doi:10.1038/nrgastro.2017.186

Increased relative abundance of Fusobacterium species contributes to the difference in intestinal bacterial composition between healthy individuals and patients with colorectal cancer (CRC). A new study now reveals that live Fusobacterium originating from primary CRC associate with liver metastasis, suggesting a potentially important function for this bacterial genus in metastatic tumour growth.
Full Text | PDF

Pancreatic cancer: Next-generation algorithms for neoantigen selection
Alexander Hopkins & Elizabeth Jaffee

Published online: 10 January 2018
p135 | doi:10.1038/nrgastro.2017.184

Predicting clinical outcomes in cancer using neoantigen burden is imperfect because current algorithms use only the binding affinity of putative neoantigens to HLA. A new study models pancreatic tumour response through a deeper understanding of tumour immunology, providing new tools for identifying neoantigens and characteristics that define their quality.
Full Text | PDF

A new open access, multi-and interdisciplinary journal dedicated to publishing the finest research on both microbial biofilms and microbiomes, the journal is now open for submissions.
Explore the benefits of submitting your next research article.
Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
Chun-Ming Wong, Felice Ho-Ching Tsang & Irene Oi-Lin Ng

Published online: 10 January 2018
p137 | doi:10.1038/nrgastro.2017.169

A growing body of evidence implicates non-coding RNAs (ncRNAs) in liver carcinogenesis. In this Review, the authors summarize the pathological roles of ncRNAs in hepatocellular carcinoma and explore the potential applications of ncRNAs as diagnostic tools and therapeutic targets.
Abstract | Full Text | PDF | Supplementary information

Hirschsprung disease — integrating basic science and clinical medicine to improve outcomes
Robert O. Heuckeroth

Published online: 04 January 2018
p152 | doi:10.1038/nrgastro.2017.149

Hirschsprung disease is a serious and potentially fatal condition affecting the enteric nervous system and defined by the absence of enteric neurons in the distal bowel. This Review provides an update on the basic science discoveries that link to clinical manifestations of the disease.
Abstract | Full Text | PDF

Opioid misuse in gastroenterology and non-opioid management of abdominal pain
Eva Szigethy, Mitchell Knisely & Douglas Drossman

Published online: 15 November 2017
p168 | doi:10.1038/nrgastro.2017.141

Chronic opioid use is increasing worldwide and has negative effects in the gastrointestinal and central nervous systems. This Review summarizes the evidence and consequences of opioid misuse in gastroenterology, as well as alternative pharmacological and nonpharmacological strategies for pain management in patients with gastrointestinal disorders.
Abstract | Full Text | PDF

Reimagining the diagnostic pathway for gastrointestinal cancer
Greg Rubin, Fiona Walter, Jon Emery & Niek de Wit

Published online: 07 February 2018
p181 | doi:10.1038/nrgastro.2018.1

If gastrointestinal cancer diagnosis is to be both timely and affordable in the future, the roles of health-care professionals need to be reframed. In this Perspectives, the authors consider how the relationship between medical specialists and generalists can be better integrated for optimal clinical outcomes and patient experience.
Abstract | Full Text | PDF

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