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vrijdag 23 februari 2018

Nature Reviews Cancer contents March 2018 Volume 18 Number 3 135-201

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Nature Reviews Cancer

Visualize, Analyze, and Phenotype Immune Cells in the Tumor Microenvironment

Gain a deeper understanding of the complex interactions in the tumor microenvironment and assess cancer biomarkers with seven-color multispectral imaging of FFPE tissue sections and TMAs in situ on the Vectra Polaris™ quantitative pathology imaging system. 

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March 2018 Volume 18 Number 3 Advertisement
Nature Reviews Cancer cover
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28
In this issue
Research Highlights
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 Featured article:
Impact of oncogenic pathways on evasion of antitumour immune responses
Stefani Spranger & Thomas F. Gajewski


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Featuring keynote speaker Lewis Cantley (Weill Cornell Medical College), this symposium will highlight mechanisms of tumor metabolism and signaling and explore current strategies to design safe and effective, metabolism-targeted cancer therapies.
Abstract deadline March 23rd.
Animation on CRISPR: Gene editing and beyond 

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next. 

Watch the Animation >> 

Produced with support from: 
npj Breast Cancer is an online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. All content from the journal is now included in PubMed Central and PubMed. Part of the Nature Partner Journal series, npj Breast Cancer is published in partnership with the Breast Cancer Research Foundation. 

Immunotherapy: Viral reprogramming
p135 | doi:10.1038/nrc.2018.12
Two studies have shown that oncolytic virus treatment prior to surgery can prime the tumour immune microenvironment for subsequent immune checkpoint inhibition and lead to better outcomes in preclinical models of breast and brain cancers.

Breast cancer: Staying silent
p136 | doi:10.1038/nrc.2018.17
Mitogen- and stress-activated kinase 1 (MSK1) has been identified as an epigenetic modulator of luminal gene expression in breast cancer, maintaining latency of bone micrometastases.

Tumour microenvironment: Fibroblast subtype provides niche for cancer stem cells
p136 | doi:10.1038/nrc.2018.18
A subset of cancer-associated firboblasts, defined by the presence of the cell surface markers CD10 and GPR77, promotes tumour formation and chemoresistance by providing a niche for cancer stem cells.

Genomic instability: The sting of metastasis
p137 | doi:10.1038/nrc.2018.16
Data presented by Bakhoum, Ngo et al. suggest that chromosomal instability can promote metastasis through a cGAS-STING-dependent response to cytosolic DNA.


Nature Reviews Cancer
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Boehringer Ingelheim
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Poster on: CAR T cells in cancer therapy 

Nature Reviews Drug Discovery present this Poster which provides an overview of the different ways to design and produce CAR T cells and the journey that has driven these CAR T cells to FDA approval in 2017. 

Download free today 

Produced with support from: 
Lonza Bioscience Solutions
Impact of oncogenic pathways on evasion of antitumour immune responses
Stefani Spranger & Thomas F. Gajewski

p139 | doi:10.1038/nrc.2017.117
This Review describes tumour cell-intrinsic oncogenic pathways implicated in tumour immune evasion and highlights the potential for targeting these pathways to overcome resistance to immunotherapy in various cancer types.
Abstract | Full Text | PDF

Targeting B cell receptor signalling in cancer: preclinical and clinical advances
Jan A. Burger & Adrian Wiestner

p148 | doi:10.1038/nrc.2017.121
In this Review, Burger and Wiestner describe the latest insights into B cell receptor (BCR) signalling with respect to its contribution to B cell malignancies and discuss how inhibitors that target kinases downstream of the BCR are changing treatment outcomes for patients with B cell neoplasms.
Abstract | Full Text | PDF

Fanconi anaemia and cancer: an intricate relationship
Grzegorz Nalepa & D. Wade Clapp

p168 | doi:10.1038/nrc.2017.116
Fanconi anaemia (FA) is a genetic disorder associated with bone marrow failure, congenital abnormalities and an increased risk of developing cancer. In this Review, Nalepa and Clapp describe the roles of FA proteins in maintaining genome homeostasis and explain how dysregulation of the FA pathway through mutations in the FA genes might lead to carcinogenesis.
Abstract | Full Text | PDF

Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

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A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Despina Soteriou & Yaron Fuchs

p187 | doi:10.1038/nrc.2017.122
Stem cells are long-lived and possess unique mechanisms related to quiescence, DNA damage response and apoptosis that protect them throughout their lifespan and during tissue repair. These mechanisms may also have a role in cancer stem cells and tumorigenesis.
Abstract | Full Text | PDF

npj Genomic Medicine is an open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. All content from the journal is now included in PubMed Central and PubMed.
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