We bring you the latest news from the healthcare about the health care in the United Kingdom.

donderdag 25 januari 2018

The Lancet: [News] International access to major US cancer database halted

[News] International access to major US cancer database halted
The US Government has halted access of non-US researchers to an important cancer database, The Lancet Oncology has confirmed.
Read more

[Comment] A start towards immunotherapy in sarcomas?
Few data are available on the immunological aspects of soft tissue and bone sarcomas compared with other types of cancer, such as malignant melanoma. In 2013, Rusakiewicz and colleagues1 investigated the immune infiltrates of gastrointestinal stromal tumours and found that CD3-positive tumour-infiltrating lymphocytes were highly activated and particularly present in areas of tumour tissue that conserved class I major histocompatibility complex (MHC) expression despite imatinib therapy. Subsequently, Tawbi and colleagues2 treated 86 patients who had advanced bone and soft tissue sarcomas with pembrolizumab in a phase 2 study and observed nine responses in 80 evaluable patients.
Read more

[Articles] Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials
Nivolumab alone does not warrant further study in an unselected sarcoma population given the limited efficacy. Nivolumab combined with ipilimumab demonstrated promising efficacy in certain sarcoma subtypes, with a manageable safety profile comparable to current available treatment options. The combination therapy met its predefined primary study endpoint; further evaluation of nivolumab plus ipilimumab in a randomised study is warranted.
Read more

[Comment] Cancer in pregnancy: evidence, or still empiricism?
Taking responsibility for a pregnant woman diagnosed with cancer and her unborn child is challenging for every physician. Therefore, an expert interdisciplinary team involving gynaecologists, medical oncologists, neonatologists, obstetricians, pathologists, psychologists, and radiotherapists is necessary to achieve the best oncological result for the woman and avoid morbidity for the fetus.
Read more

[Articles] Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients
Over the years, the proportion of patients with cancer during pregnancy who received antenatal treatment increased, especially treatment with chemotherapy. Our data indicate that babies exposed to antenatal chemotherapy might be more likely to develop complications, specifically small for gestational age and NICU admission, than babies not exposed. We therefore recommend involving hospitals with obstetric high-care units in the management of these patients.
Read more