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zaterdag 20 januari 2018

The Lancet: [Comment] The long road towards a safe and effective treatment of chronic Chagas disease

[Comment] The long road towards a safe and effective treatment of chronic Chagas disease
Chagas disease, a chronic systemic parasitosis by the kinetoplastid protozoon Trypanosoma cruzi, is the leading cause of cardiac morbidity and mortality in poor rural and suburban areas of Latin America and the source of the largest parasitic disease burden in the American continent. This burden is now spreading worldwide owing to international migration.1,2 A recent change in the scientific understanding of the pathogenesis of chronic Chagas disease has led to consensus that all T cruzi-seropositive patients should receive aetiological treatment with anti-T cruzi drugs.
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[Articles] Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial
E1224 is the first new chemical entity developed for Chagas disease in decades. E1224 displayed a transient, suppressive effect on parasite clearance, whereas benznidazole showed early and sustained efficacy until 12 months of follow-up. Despite PCR limitations, our results support increased diagnosis and access to benznidazole standard regimen, and provide a development roadmap for novel benznidazole regimens in monotherapy and in combinations with E1224.
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[Correspondence] Genomic characterisation of human monkeypox virus in Nigeria
Monkeypox virus (MPXV) is a large, double-stranded DNA virus belonging to the Orthopox genus in the family Poxviridae. First identified in 1958, MPXV has caused sporadic human outbreaks in central and west Africa, with a mortality rate between 1% and 10%.1 Viral genomes from west Africa and the Congo Basin separate into two clades, the latter being more virulent.2 Recently, MPXV outbreaks have occurred in Sudan (2005), the Republic of the Congo and Democratic Republic of the Congo (2009), and the Central African Republic (2016).
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[Corrections] Corrections
Freer JB, Bourke CD, Durhuus GH, Kjetland EF, Prendergast AJ. Schistosomiasis in the first 1000 days. Lancet Infect Dis 2017; published online Nov 20. http://dx.doi.org/10.1016/S1473-3099(17)30490-5—An incorrect value was used to describe the average duration of a human pregnancy; this has been corrected throughout. These corrections have been made to the online version as of Jan 18, 2018.
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[Articles] Chlamydia trachomatis and the risk of spontaneous preterm birth, babies who are born small for gestational age, and stillbirth: a population-based cohort study
A genital chlamydia infection that is diagnosed and, presumably, treated either during or before pregnancy does not substantially increase a woman's risk of having a spontaneous preterm birth, having a baby who is small for gestational age, or having a stillbirth.
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