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donderdag 11 januari 2018

The Lancet: [Comment] Ending tuberculosis calls for leaving no one behind

[Comment] Ending tuberculosis calls for leaving no one behind
In The Lancet Infectious Diseases, Timothy Walker and colleagues1 report on a cluster of 29 multidrug-resistant tuberculosis cases among asylum seekers arriving in Europe from the Horn of Africa. They use whole-genome sequencing to identify the transmission links and describe the cross-border collaboration and control measures. Their study is of interest as it sheds light on the importance of early tuberculosis detection and highlights the potential of wide application of molecular epidemiology techniques.
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[Articles] A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study
Our data suggest that source cases are linked to an M tuberculosis clone circulating in northern Somalia or Djibouti and that transmission probably occurred en route before arrival in Europe. We hypothesise that the shared mutation of tlyA is a drug resistance mutation and phylogenetic marker, the first of its kind in M tuberculosis sensu stricto.
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[Articles] Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study
Single infusions of SAB-301 up to 50 mg/kg appear to be safe and well tolerated in healthy participants. Human immunoglobulin derived from transchromosomic cattle could offer a new platform technology to produce fully human polyclonal IgG antibodies for other medical conditions.
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[Comment] Herd immunity: hyperimmune globulins for the 21st century
Recent headlines, including outbreaks of Ebola virus disease in urban west Africa, the intercontinental transmission of Middle East respiratory syndrome virus (MERS) from the Arabian Peninsula to South Korea, and the emergence of Zika virus as a fetal neurotoxic agent, highlight the global threat posed by emerging infectious diseases in an increasingly connected world.
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[Corrections] Corrections
Walker TM, Merker M, Knoblauch AM, et al. A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study. Lancet Infect Dis 2018 published online Jan 8. http://dx.doi.org/10.1016/S1473-3099(18)30004-5—In this Article, the appendix file has been replaced with the correct version. This correction has been made to the online version as of Jan 10, 2018.
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