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woensdag 3 januari 2018

Nature Reviews Urology - Table of Contents alert Volume 15 Issue 1

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Nature Reviews Urology
January 2018 Volume 15 Number 1
Nature Reviews Urology cover
2016 2-year Impact Factor 7.735
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
The inflammatory microenvironment and microbiome in prostate cancer development
Karen S. Sfanos, Srinivasan Yegnasubramanian, William G. Nelson and Angelo M. De Marzo


Recommend to library

Bladder cancer: Genomics of noninvasive disease
Published online: 05 December 2017
p1 | doi:10.1038/nrurol.2017.207


Prostate cancer: A nervous disposition: the angiometabolic switch
Published online: 21 November 2017
p2 | doi:10.1038/nrurol.2017.200


Prostate cancer: Glycolysis and AR expression as biomarkers
Published online: 28 November 2017
p2 | doi:10.1038/nrurol.2017.205


Prostate cancer: H2A.Zac activates neo-enhancers
Published online: 28 November 2017
p3 | doi:10.1038/nrurol.2017.202


Prostate cancer: Stuck in the middle: interstitial genes in TMPRSS2-ERG fusion
Published online: 05 December 2017
p3 | doi:10.1038/nrurol.2017.208


Prostate cancer: Conserved lipid synthesis drives castration resistance
Published online: 14 November 2017
p4 | doi:10.1038/nrurol.2017.198



Nature Reviews Urology
JOBS of the week
Postdoctoral fellow
Karolinska Institutet (KI)
Assistant Professor or Associate Professor
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Postdoctoral Research Associate
Benaroya Research Institute at Virginia Mason (BRI)
postdoctoral researcher
The University of Iowa
More Science jobs from
Nature Reviews Urology
The 4th Friends of Israel Urological Symposium
Tel Aviv, Israel
More science events from
Penile cancer: Targeted therapy in penile cancer: a new treatment paradigm
Mounsif Azizi & Philippe E. Spiess

Published online: 31 October 2017
p5 | doi:10.1038/nrurol.2017.183

Current advances in the understanding of penile carcinogenesis provide the possibility for new personalized and actionable targeted therapeutic approaches to improve outcomes in men with advanced penile cancer. Targeting the human epidermal growth factor receptor pathway showed promising results in a recent phase II trial of first-line therapy with dacomitinib.
Full Text | PDF

Imaging: MRI improves cost and accuracy of prostate cancer biopsy
James Thompson & Phillip Stricker

Published online: 08 November 2017
p6 | doi:10.1038/nrurol.2017.185

Randomized trials of screening for localized prostate cancer on the basis of crude PSA thresholds and 6-12-core template biopsies had disappointing results. To improve patient outcomes, novel diagnostic tools with a high discriminative ability for clinically significant cancer are needed. The use of MRI can improve detection at biopsy without disproportionate increases in costs.
Full Text | PDF

Stones: Predicting stone episodes using cystine capacity
Matthew Bultitude & Kay Thomas

Published online: 14 November 2017
p8 | doi:10.1038/nrurol.2017.189

Cystine capacity is an assay for assessing urinary cystine saturation and risk of a stone episode in patients with cystinuria. Lowering the threshold for this test improves its sensitivity, potentially enabling relaxation of follow-up regimens for patients at lowest risk of stone episodes and dose modification of medications for those at highest risk.
Full Text | PDF
The inflammatory microenvironment and microbiome in prostate cancer development
Karen S. Sfanos, Srinivasan Yegnasubramanian, William G. Nelson & Angelo M. De Marzo

Published online: 31 October 2017
p11 | doi:10.1038/nrurol.2017.167

Sfanos et al. discuss the potentially procarcinogenic role of prostatic infections and inflammation in prostate pathogenesis. They summarize findings that suggest that an aberrant microbiome together with an inflammatory microenvironment are involved in the initiation of prostate cancer precursor lesions.
Abstract | Full Text | PDF

A psychosocial approach to female genital pain
Marieke Dewitte, Charmaine Borg & Lior Lowenstein

Published online: 28 November 2017
p25 | doi:10.1038/nrurol.2017.187

Despite its prevalence, sexual pain in women is poorly understood as it exists at the intersection of different biopsychosocial disciplines. In this Review, experts in the field describe how confusion remains at the nosological, aetiological, theoretical, methodological, and treatment levels and how a psychosocial approach can help to overcome this lack of consensus to improve theoretical models and effective treatments.
Abstract | Full Text | PDF

Stimulators and activators of soluble guanylate cyclase for urogenital disorders
Fabiola Z. Monica & Edson Antunes

Published online: 14 November 2017
p42 | doi:10.1038/nrurol.2017.181

In this Review, the authors describe the role of the NO-sGC-cGMP signalling pathway in disease pathophysiology of urogenital tissue. They discuss advances in directly targeting sGC to enhance cGMP production independently using NO-independent stimulators and activators of sGC and the potential of these molecules for treating urogenital disorders.
Abstract | Full Text | PDF

Managing high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands on prostate biopsy
Jeffrey J. Tosoian et al.

Published online: 31 August 2017
p55 | doi:10.1038/nrurol.2017.134

High-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands suspicious for carcinoma are two prostate cancer diagnoses without standardized follow up and treatment pathways. In this Review, Tosoian and colleagues describe data that have shed light on these phenomena. The improved understanding of the implications of the presence of HGPIN and atypical glands on prostate biopsy means that clinical recommendations can be made for the management of patients with these diagnoses.
Abstract | Full Text | PDF

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*Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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