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vrijdag 19 januari 2018

Nature Reviews Neuroscience contents February 2018 Volume 19 Number 2 pp 59-118

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Nature Reviews Neuroscience
February 2018 Volume 19 Number 2
Nature Reviews Neuroscience cover
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23
In this issue
Research Highlights
Also this month
Article series:
Food intake, metabolism and the brain
 Featured article:
Mitochondria at the neuronal presynapse in health and disease
Michael J. Devine & Josef T. Kittler


Recommend to library

Learning and memory: You only learn once
p59 | doi:10.1038/nrn.2018.4
When mice explore a new context, neurons in the locus coeruleus that project to hippocampal regions CA3 enable the learning of the new environment.


Neural coding: Investigating social spaces
p60 | doi:10.1038/nrn.2017.169
In mice, projections from the prelimbic cortex to the nucleus accumbens encode a combination of social and spatial information and may promote 'social investigation' behaviour by enabling social–spatial learning.


Neuroimmunology: Brain police
p60 | doi:10.1038/nrn.2018.5
Microglial surveillance of the brain is dependent on maintenance of microglia membrane potential by the K+ channel THIK1, which is potentiated by ATP released at sites of tissue injury acting on P2Y12 receptors.


Neurodegenerative disease: A proteostatic boost
p61 | doi:10.1038/nrn.2018.3
Amyloid-β (Aβ)-induced proteotoxicity is linked to a mitochondrial stress response that may be conserved across species, and promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model.



Nature Collection: 2017 Nobel Prize in Physiology or Medicine

The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm. 

Access this collection free online>>

Produced with support from: 
Vanda Pharmaceuticals
Article series: Food intake, metabolism and the brain
Intermittent metabolic switching, neuroplasticity and brain health
Mark P. Mattson et al.

p63 | doi:10.1038/nrn.2017.156
Eating patterns in modern societies often preclude the metabolic switch from utilization of glucose to ketones as a cellular energy source. In this Review, Mattson and colleagues discuss how intermittent metabolic switching impacts brain function and vulnerability to injury and disease.
Abstract | Full Text | PDF

Mitochondria at the neuronal presynapse in health and disease
Michael J. Devine & Josef T. Kittler

p63 | doi:10.1038/nrn.2017.170
Mitochondria may be actively recruited to presynapses to supply energy, buffer calcium and, potentially, fulfil other functions. In this Review, Devine and Kittler examine the importance of this presynaptic population of mitochondria in the maintenance of neuronal homeostasis and how dysfunctional presynaptic mitochondria might contribute to neurodegenerative diseases.
Abstract | Full Text | PDF

Article series: Food intake, metabolism and the brain
Leptin and the maintenance of elevated body weight
Warren W. Pan & Martin G. Myers, Jr

p95 | doi:10.1038/nrn.2017.168
Although leptin administration decreases food intake and body weight in lean mice, it has no effect in obese mice. In this Review, Pan and Myers discuss how leptin action becomes dysfunctional in obesity and suggest that elevated leptin levels promote processes that limit leptin action.
Abstract | Full Text | PDF

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Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity
Vincenzo Crunelli et al.

p107 | doi:10.1038/nrn.2017.151
During low-vigilance states, thalamic neurons exhibit diverse rhythmic activities that contribute to specific parts of the electroencephalogram rhythm. In this perspective, Crunelli and colleagues propose that thalamic oscillations of these low-vigilance states also have a plasticity function that modifies the strength of excitatory and inhibitory synapses in local neuronal assemblies.
Abstract | Full Text | PDF

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