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maandag 29 januari 2018

Nature Immunology Contents: February 2018 Volume 19 Issue 2

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Nature Immunology

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TABLE OF CONTENTS

February 2018 Volume 19, Issue 2

Research Highlights
News & Views
Review Articles
Articles
 
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Research Highlights

 

Adipose tissue TM cells    p99
Ioana Visan
doi:10.1038/s41590-017-0036-4

Myocardial infarct inflammation    p99
Ioana Visan
doi:10.1038/s41590-017-0037-3

Stress-induced depression    p99
Laurie A. Dempsey
doi:10.1038/s41590-017-0038-2

NKT cells aid antiviral responses    p99
Laurie A. Dempsey
doi:10.1038/s41590-017-0039-1

Macrophages: damage control    p99
Zoltan Fehervari
doi:10.1038/s41590-017-0040-8

Antibiotics–immune system interactions    p99
Zoltan Fehervari
doi:10.1038/s41590-017-0041-7

News & Views

 

mTECs Aire on the side of caution    pp100 - 101
Alexandra Bortnick & Cornelis Murre
doi:10.1038/s41590-017-0033-7

Trials and Tribble-ations of tissue TRM cells    pp102 - 103
Jun Siong Low & Susan M. Kaech
doi:10.1038/s41590-017-0031-9

Stressed-out ROS take a silent death route    pp103 - 105
Sannula Kesavardhana & Thirumala-Devi Kanneganti
doi:10.1038/s41590-017-0034-6

ERAdP standing in the shadow of STING innate immune signaling    pp105 - 107
Martin Roelsgaard Jakobsen
doi:10.1038/s41590-017-0026-6

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Review Articles

 

Myeloid-derived suppressor cells coming of age    pp108 - 119
Filippo Veglia, Michela Perego & Dmitry Gabrilovich
doi:10.1038/s41590-017-0022-x

Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.

 

RNA-binding proteins control gene expression and cell fate in the immune system    pp120 - 129
Martin Turner & Manuel D. Díaz-Muñoz
doi:10.1038/s41590-017-0028-4

Turner and Díaz-Muñoz discuss the molecular mechanisms by which RNA-binding proteins modulate the diversity of the transcriptome and proteome in immune cells.

 

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Articles

 

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway    pp130 - 140
Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al.
doi:10.1038/s41590-017-0013-y

Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.

 

The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity    pp141 - 150
Pengyan Xia, Shuo Wang, Zhen Xiong, Xiaoxiao Zhu, Buqing Ye et al.
doi:10.1038/s41590-017-0014-x

The bacterial secondary messenger c-di-AMP can be sensed by cytosolic receptors to activate innate immunity. Fan and colleagues show the ER-associated protein ERAdP to be a high-affinity receptor for c-di-AMP, linking it to downstream inflammatory responses.

 

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1    pp151 - 161
Charise Garber, Michael J. Vasek, Lauren L. Vollmer, Tony Sun, Xiaoping Jiang et al.
doi:10.1038/s41590-017-0021-y

Klein and colleagues show, in a mouse model of West Nile virus–induced cognitive dysfunction, that neurogenesis is impaired by production of IL-1 from pro-inflammatory astrocytes.

 

Rapid chromatin repression by Aire provides precise control of immune tolerance    pp162 - 172
Andrew S. Koh, Erik L. Miller, Jason D. Buenrostro, David M. Moskowitz, Jing Wang et al.
doi:10.1038/s41590-017-0032-8

Crabtree and colleagues show that Aire has an intrinsic repressive function that restricts chromatin accessibility and restrains the amplitude of active transcription.

 

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory    pp173 - 182
Lalit K. Beura, Jason S. Mitchell, Emily A. Thompson, Jason M. Schenkel, Javed Mohammed et al.
doi:10.1038/s41590-017-0029-3

Masopust and colleagues show that mucosal tissue-resident memory T cells proliferate in situ in response to local antigen and dominate the local recall response.

 

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses    pp183 - 191
Simone L. Park, Ali Zaid, Jyh Liang Hor, Susan N. Christo, Julia E. Prier et al.
doi:10.1038/s41590-017-0027-5

Mackay, Mueller and colleagues show that tissue-resident memory T cells proliferate in situ in response to local antigen and persist during subsequent antigen encounters.

 

Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells    pp192 - 201
Jung Hwan Kim, John Podstawka, Yuefei Lou, Lu Li, Esther K. S. Lee et al.
doi:10.1038/s41590-017-0030-x

Yipp and colleagues report that depletion of B cells leads to the accumulation of aged polymorphonuclear cells in the lungs, which causes fibrotic interstitial lung disease.

 

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