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Nature Immunology Contents: February 2018 Volume 19 Issue 2

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Nature Immunology

To mark the 100th anniversary of the 1918 influenza pandemic, Nature Reviews Microbiology presents a collection including Reviews and research articles from across Nature Research to showcase the latest advances in our understanding of influenza virus biology, evolution and adaptation, and advances in surveillance and drug and vaccine development.

Access the collection online.

February 2018 Volume 19, Issue 2

Research Highlights
News & Views
Review Articles

npj Microgravity is a new open access journal specifically dedicated to publishing research which enables space exploration and research that is enabled by spaceflight and ground-based spaceflight analogues. npj Microgravity is published in cooperation the Biodesign Institute at Arizona State University, and is part of the Nature Partner Journals series.  

Nature Outlook: Cancer immunotherapy 

Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic. 

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Lower house prices, proximity to Tokyo, and a burgeoning R&D ecosystem are thrusting Kanagawa into the modern world from its ancient history.

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Research Highlights


Adipose tissue TM cells    p99
Ioana Visan

Myocardial infarct inflammation    p99
Ioana Visan

Stress-induced depression    p99
Laurie A. Dempsey

NKT cells aid antiviral responses    p99
Laurie A. Dempsey

Macrophages: damage control    p99
Zoltan Fehervari

Antibiotics–immune system interactions    p99
Zoltan Fehervari

News & Views


mTECs Aire on the side of caution    pp100 - 101
Alexandra Bortnick & Cornelis Murre

Trials and Tribble-ations of tissue TRM cells    pp102 - 103
Jun Siong Low & Susan M. Kaech

Stressed-out ROS take a silent death route    pp103 - 105
Sannula Kesavardhana & Thirumala-Devi Kanneganti

ERAdP standing in the shadow of STING innate immune signaling    pp105 - 107
Martin Roelsgaard Jakobsen

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Review Articles


Myeloid-derived suppressor cells coming of age    pp108 - 119
Filippo Veglia, Michela Perego & Dmitry Gabrilovich

Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.


RNA-binding proteins control gene expression and cell fate in the immune system    pp120 - 129
Martin Turner & Manuel D. Díaz-Muñoz

Turner and Díaz-Muñoz discuss the molecular mechanisms by which RNA-binding proteins modulate the diversity of the transcriptome and proteome in immune cells.


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Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway    pp130 - 140
Cathleen Holze, Chloé Michaudel, Claire Mackowiak, Darya A. Haas, Christian Benda et al.

Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.


The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity    pp141 - 150
Pengyan Xia, Shuo Wang, Zhen Xiong, Xiaoxiao Zhu, Buqing Ye et al.

The bacterial secondary messenger c-di-AMP can be sensed by cytosolic receptors to activate innate immunity. Fan and colleagues show the ER-associated protein ERAdP to be a high-affinity receptor for c-di-AMP, linking it to downstream inflammatory responses.


Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1    pp151 - 161
Charise Garber, Michael J. Vasek, Lauren L. Vollmer, Tony Sun, Xiaoping Jiang et al.

Klein and colleagues show, in a mouse model of West Nile virus–induced cognitive dysfunction, that neurogenesis is impaired by production of IL-1 from pro-inflammatory astrocytes.


Rapid chromatin repression by Aire provides precise control of immune tolerance    pp162 - 172
Andrew S. Koh, Erik L. Miller, Jason D. Buenrostro, David M. Moskowitz, Jing Wang et al.

Crabtree and colleagues show that Aire has an intrinsic repressive function that restricts chromatin accessibility and restrains the amplitude of active transcription.


Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory    pp173 - 182
Lalit K. Beura, Jason S. Mitchell, Emily A. Thompson, Jason M. Schenkel, Javed Mohammed et al.

Masopust and colleagues show that mucosal tissue-resident memory T cells proliferate in situ in response to local antigen and dominate the local recall response.


Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses    pp183 - 191
Simone L. Park, Ali Zaid, Jyh Liang Hor, Susan N. Christo, Julia E. Prier et al.

Mackay, Mueller and colleagues show that tissue-resident memory T cells proliferate in situ in response to local antigen and persist during subsequent antigen encounters.


Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells    pp192 - 201
Jung Hwan Kim, John Podstawka, Yuefei Lou, Lu Li, Esther K. S. Lee et al.

Yipp and colleagues report that depletion of B cells leads to the accumulation of aged polymorphonuclear cells in the lungs, which causes fibrotic interstitial lung disease.


Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.
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