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Nature Cell Biology contents: February 2018 Volume 20 Number 2

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Nature Cell Biology

Do You Know What's in Your Cell Culture? 

There might be other things on your plate than expected. Unlock some secrets of small additional steps you can take to become an expert in cell handling mastering the daily challenge of contamination prevention.
Eppendorf AG

February 2018 Volume 20, Issue 2

News & Views
Amendments & Corrections

Stem cell flow cytometry training course (Mar 14-15, 2018)

This 2-day hands-on training course at Miltenyi Biotec/Germany focuses on the basic principles of stem cell research. Combining lectures and practical lab sessions, a complete workflow covering flow cytometric analysis, cultivation and characterization methods will be introduced.
Naturejobs Career Guide China 2018

China's scientific landscape is shifting fast. Where can you fit in? Read the latest issue of our career guide to see what opportunities await you. 

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nature.com webcasts

Springer Nature presents a custom webcast on: Applications of imaging flow cytometry for the diagnosis of leukaemia

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Means and myths of mentoring    p117

News & Views


Mitochondrial DNA selection in human germ cells    pp118 - 120
Di Chen & Amander T. Clark

Exonuclease EXD2 in mitochondrial translation    pp120 - 122
Brian M. Zid & Pankaj Kapahi

Hitchhiking on selective autophagy    pp122 - 124
Christian M√ľnch & Ivan Dikic

Illuminating MSK1's role in tumour dormancy    pp124 - 126
Candice Alexandra Grzelak & Cyrus Michael Ghajar

Nature Cell Biology
JOBS of the week
Research Fellow
Queen's University Belfast
Postdoctoral Associate
University of Pittsburgh
Assistant, Associate, or Full Professor
Thomas Jefferson University, Sidney Kimmel Cancer Center
Postdoctoral Fellow
University Health Network (Toronto)
Research Fellowship
The University of York
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Cellular Biology of Addiction (Cambridge, UK)
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Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation    pp127 - 134
Ximena Ibarra-Soria, Wajid Jawaid, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone et al.

Ibarra-Soria et al. study cellular diversity, transcriptional signatures, lineage specification and somitogenesis on a single-cell level in E8.25 mouse embryos, and reveal the regulation of blood progenitor formation by the leukotriene pathway.


Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy    pp135 - 143
Heeseon An & J. Wade Harper

An and Harper quantify ribophagy in mammalian cells and show that nutrient-deprivation-induced ribophagy is independent of the ATG8 conjugation system, whereas proteotoxic stress-induced ribophagy requires ATG5 and VPS34.


Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos    pp144 - 151
Vasileios I. Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred W. C. Tang et al.

Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development.


Receive up to $35,000 to fund your science outreach project

The ASCB Public Engagement Grants will provide funding, mentoring, and project assessment to ASCB members interested in public outreach in scientific areas. Funded by the Simons Foundation's Science Sandbox.

Apply for a Grant



Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells    pp152 - 161
Jun Chen, Na Xu, Chenhui Wang, Pin Huang, Huanwei Huang et al.

Chen et al. demonstrate that transient Scute activation induces asymmetric division in Drosophila intestinal stem cells, which generates enteroendocrine progenitor cells that divide once before differentiation to yield a pair of enteroendocrine cells.


EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation    pp162 - 174
Joana Silva, Suvi Aivio, Philip A. Knobel, Laura J. Bailey, Andreu Casali et al.

By analysing the exonuclease EXD2, Silva et al. find that it localizes to mitochondria, and that its loss alters metabolism by affecting mitochondrial translation and causes developmental delay and lifespan extension in flies.


Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis    pp175 - 185
Chien-Ting Wu, Hsin-Yi Chen & Tang K. Tang

Wu et al. show that myosin-Va is needed for the initiation of primary cilia formation by transporting preciliary vesicles to the distal appendages of the mother centriole in a manner dependent on both microtubules and centrosomal actin.


RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis    pp186 - 197
Zhentao Yang, Yan Wang, Yingying Zhang, Xiadi He, Chuan-Qi Zhong et al.

RIP3 regulates mitochondrial metabolism. Yang et al. show that RIP3 activates the pyruvate dehydrogenase complex to enhance aerobic respiration and increase mitochondrial ROS during necroptosis, and MLKL is required for RIP3 translocation to mitochondria.


The MTM1–UBQLN2–HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle    pp198 - 210
Christos Gavriilidis, Leila Laredj, Romain Solinhac, Nadia Messaddeq, Julien Viaud et al.

Gavriilidis et al. show that MTM1, which is mutated in X-linked centronuclear myopathy, and UBQLN2 recognize misfolded desmin and vimentin and trigger their degradation to clear misfolded intermediated filaments prior to aggregate formation.


MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer    pp211 - 221
Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique J. Arenas, Fernando Salvador et al.

Gawrzak et al. show that MSK1 regulates bone metastatic dormancy of ER+ breast cancer. MSK1 affects histone modifications at luminal transcription factor promoters to prevent cell differentiation and bone homing.


Nature Mentoring Collection

Offering advice and support to scientist mentors and their mentees

Access the Collection>>

Amendments & Corrections


Author Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi    p222


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