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woensdag 10 januari 2018

Nature Biotechnology Contents: Volume 36 pp 1 - 116

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Nature Biotechnology

GTEx Collection

Nature Research is pleased to present this Collection of Commentary, News and Research from across the Nature journals for the second phase of the GTEx project. 

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January 2018 Volume 36, Issue 1

News Feature
Opinion and Comment
News and Views
Careers and Recruitment

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Nature Collection: 2017 Nobel Prize in Physiology or Medicine

The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm. 

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Vanda Pharmaceuticals


Aligning stars of all colors    p1


Drugmakers cling to dual IL-13/IL-4 blockbuster hopes    pp3 - 5
Cormac Sheridan

AI for your heart, on your wrist    p5

First in vivo human genome editing trial    p5

FDA approves hereditary blindness gene therapy    p6

With a free pass, CRISPR-edited plants reach market in record time    pp6 - 7
Emily Waltz

China's fledgling biotech sector fizzes into life    pp8 - 9
Shannon Ellis

FDA to relax grip on at-home genetic tests, but concerns linger    pp10 - 11
Mark Ratner

PODCAST: First rounders: Susan Windham-Bannister    p11

Bluebird's BCMA CAR-T impresses at ASH    p11

Texas displays 'Silicon Valley' credentials to lure Brazilian biotechs    pp12 - 13
Melanie Senior

Around the world in a month    p13

News Feature

DNA makes an appearance    pp14 - 17
Laura DeFrancesco

An online-only, open access journal publishing high-quality original papers and review articles relevant to all aspects of digital medicine and health, npj Digital Medicine has now published its first articles. Part of the Nature Partner Journals series, npj Digital Medicine is published in partnership with the Scripps Translational Science Institute.

Opinion and Comment


Why the European Union needs a national GMO opt-in mechanism    pp18 - 19
Dennis Eriksson, Eugénia de Andrade, Borut Bohanec, Sevasti Chatzopolou, Roberto Defez et al.


Biotech's pale shadow    pp20 - 30
Brady Huggett


Mapping the global influence of published research on industry and innovation    pp31 - 39
Osmat A Jefferson, Adam Jaffe, Doug Ashton, Ben Warren, Deniz Koellhofer et al.

Recent patents in proteomics    p40

npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines.npj Vaccines is now open for submissions.
Explore the benefits of submitting your next manuscript to the journal

News and Views

Strength in numbers from integrated single-cell neuroscience    pp41 - 42
Rahul Satija

Viruses leave their stamp on single cells    pp42 - 44
Ede A Rancz & Andreas T Schaefer

RNA-targeting CRISPR comes of age    pp44 - 45
V Narry Kim

Research Highlights    p45

JOBS of the week
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Experimental (wet-lab) postdoctoral position in proteomics at Cornell University
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Precision oncology in the age of integrative genomics    pp46 - 60
Chandan Kumar-Sinha & Arul M Chinnaiyan
Chandan Kumar-Sinha and Arul Chinnaiyan summarize the increasing use of sequencing panels to screen for cancer-associated genes in tumor and germline samples. The authors highlight the increasing appreciation of aberrations in regulatory genes or chromatin-related genes and argue that precision oncology must be considered in the context of adding value to the standard of care, not apart from it.


Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation    pp61 - 69
John Beaulaurier, Shijia Zhu, Gintaras Deikus, Ilaria Mogno, Xue-Song Zhang et al.
Similar bacterial species and strains in metagenomes are resolved and linked to the plasmids that they harbor using DNA methylation analysis.

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain    pp70 - 80
Blue B Lake, Song Chen, Brandon C Sos, Jean Fan, Gwendolyn E Kaeser et al.
Single-cell analysis of the adult human brain is facilitated by improved methods for RNA-seq and hypersensitive-site mapping.

Virus stamping for targeted single-cell infection in vitro and in vivo    pp81 - 88
Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan et al.
Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers.

Multiplexed droplet single-cell RNA-sequencing using natural genetic variation    pp89 - 94
Hyun Min Kang, Meena Subramaniam, Sasha Targ, Michelle Nguyen, Lenka Maliskova et al.
Droplet single-cell RNA-seq is applied to large numbers of pooled samples from unrelated individuals.


Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency    pp95 - 102
Marella D Canny, Nathalie Moatti, Leo C K Wan, Amélie Fradet-Turcotte, Danielle Krasner et al.
Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells.


Global landscape of cell envelope protein complexes in Escherichia coli    pp103 - 112
Mohan Babu, Cedoljub Bundalovic-Torma, Charles Calmettes, Sadhna Phanse, Qingzhou Zhang et al.
A survey of cell envelope proteins and their interacting partners in E. coli by mass spectrometry reveals insights into essential bacterial processes.

Careers and Recruitment

Mentoring for diversity in technology    pp113 - 115
Maggie Werner-Washburne


People    p116

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