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Laboratory Investigation - Table of Contents alert Volume 98 Issue 1

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Laboratory Investigation

Volume 98, Issue 1 (January 2018)

In this issue
Inside the USCAP Journals
Pathobiology in Focus
Mini Reviews
Research Articles
Technical Report

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Inside the USCAP Journals


Inside the USCAP Journals


2018 98: 2-3; 10.1038/labinvest.2017.135

Full Text



Cholecystectomy: a way forward and back to metabolic syndrome?

Gabriella Garruti, David Q-H Wang, Agostino Di Ciaula and Piero Portincasa

2018 98: 4-6; 10.1038/labinvest.2017.129

Abstract | Full Text

Pathobiology in Focus


Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

Recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, the authors describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.

Yongsheng Chen, Shuodong Wu and Yu Tian

2018 98: 7-14; advance online publication, September 11, 2017; 10.1038/labinvest.2017.95

Abstract | Full Text

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

Here the authors present the results of an automated digital image analysis using a new purpose-built software platform (QuPath) applied to breast cancer patients and five key biomarkers. Their findings demonstrate QuPath's suitability for fast, reproducible, high-throughput tissue microarray analysis, using tumor recognition algorithms for immunohistochemistry, trained automatically and interactively.

Peter Bankhead, José A Fernández, Darragh G McArt, David P Boyle, Gerald Li, Maurice B Loughrey, Gareth W Irwin, D Paul Harkin, Jacqueline A James, Stephen McQuaid, Manuel Salto-Tellez and Peter W Hamilton

2018 98: 15-26; advance online publication, December 18, 2017; 10.1038/labinvest.2017.131

Abstract | Full Text

Mini Reviews


Experimental models of pancreatic cancer desmoplasia

The role of stroma in pancreatic cancer is controversial, potentially due to the variability observed among different model systems. In this review, the authors extensively examine several original research studies related to various models currently available for pancreatic cancer desmoplasia, highlighting their strengths and weaknesses.

Sujit Suklabaidya, Pujarini Dash, Biswajit Das, Voddu Suresh, Prakash K Sasmal and Shantibhusan Senapati

2018 98: 27-40; advance online publication, November 20, 2017; 10.1038/labinvest.2017.127

Abstract | Full Text

Immune checkpoint inhibitors in sarcomas: in quest of predictive biomarkers

Since metastatic sarcomas are often resistant to standard radio- and chemotherapy, immune checkpoint inhibitors could provide a novel treatment option. However, the selection of patients who will respond to immune checkpoint inhibitors remains an obstacle. In this review, proposed biomarkers of immune checkpoint inhibitor response in sarcomas are discussed.

Robin Veenstra, Marie Kostine, Anne-Marie Cleton-Jansen, Noel FCC de Miranda and Judith VMG Bovée

2018 98: 41-50; advance online publication, November 20, 2017; 10.1038/labinvest.2017.128

Abstract | Full Text

Neutrophils: a cornerstone of liver ischemia and reperfusion injury

This review discusses the important role of neutrophils in ischemia and reperfusion injury in the liver. The interactions between major molecules that play a role in this pathology, including danger signals, adhesion molecules, cytokines and chemokines, glycosaminoglycans and neutrophil-derived enzymes and their target cells are discussed in detail.

Thiago Henrique Caldeira de Oliveira, Pedro Elias Marques, Paul Proost and Mauro Martins M Teixeira

2018 98: 51-62; advance online publication, September 18, 2017; 10.1038/labinvest.2017.90

Abstract | Full Text

Research Articles



NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation

This study reveals that Nox4 is significantly induced in cisplatin-treated tubular epithelial cells and in a mouse model of acute kidney injury. Nox4 aggravates cisplatin-induced nephrotoxicity possibly by promoting reactive oxygen species-mediated programmed cell death and inflammation. These results also indicate that Nox4 may serve as a potential therapeutic target in the treatment of kidney injury.

Xiao-Ming Meng, Gui-Ling Ren, Li Gao, Qin Yang, Hai-Di Li, Wei-Feng Wu, Cheng Huang, Lei Zhang, Xiong-wen Lv and Jun Li

2018 98: 63-78; advance online publication, November 6, 2017; 10.1038/labinvest.2017.120

Abstract | Full Text

Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis

The authors determined the renoprotective effects of wogonin on cisplatin-induced acute kidney injury by targeting RIPK1-dependent necroptosis. Wogonin preserves, and even promotes, the tumor-killing effect of cisplatin in different types of tumor cells. Thus, wogonin should be further evaluated as a renoprotective adjuvant for kidney injury in cisplatin-treated cancer patients.

Xiao-Ming Meng, Hai-Di Li, Wei-Feng Wu, Patrick Ming-Kuen Tang, Gui-Ling Ren, Li Gao, Xiao-Feng Li, Yang Yang, Tao Xu, Tao-Tao Ma, Zeng Li, Cheng Huang, Lei Zhang, Xiong-Wen Lv and Jun Li

2018 98: 79-94; advance online publication, December 4, 2017; 10.1038/labinvest.2017.115

Abstract | Full Text


High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models

In this study, the authors show that HOXA13 protein levels increase as normal liver progresses to cirrhotic liver to hepatocellular carcinoma (HCC). HOXA13-positive HCCs are preferentially poorly differentiated and have fewer E-cadherin-positive cells, and HOXA13 positivity is associated with worse overall survival. In vitro, HOXA13 expression enhances cell migration and modulates sorafenib responsiveness. HOXA13 may therefore be a potential predictive biomarker for sorafenib responsiveness.

Luca Quagliata, Cristina Quintavalle, Manuela Lanzafame, Matthias S Matter, Chiara Novello, Luca di Tommaso, Tiziana Pressiani, Lorenza Rimassa, Luigi Tornillo, Massimo Roncalli, Clemente Cillo, Pierlorenzo Pallante, Salvatore Piscuoglio, Charlotte KY Ng and Luigi M Terracciano

2018 98: 95-105; advance online publication, October 16, 2017; 10.1038/labinvest.2017.107

Abstract | Full Text


Mixed cell therapy of bone marrow-derived mesenchymal stem cells and articular cartilage chondrocytes ameliorates osteoarthritis development

This study aims to improve cell-based treatment for regeneration of osteoarthritic articular cartilage. The results suggest that mixed culture of bone marrow-derived stem cells and articular cartilage chondrocytes is more effective in regenerating damaged cartilage in both the ex vivo cartilage defect model and post-trauma osteoarthritic disease rat models. The results from this approach may be useful for regeneration of cartilage in osteoarthritic patients.

Indira Prasadam, Akoy Akuien, Thor E Friis, Wei Fang, Xinzhan Mao, Ross W Crawford and Yin Xiao

2018 98: 106-116; advance online publication, October 16, 2017; 10.1038/labinvest.2017.117

Abstract | Full Text

Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β

This study shows that transcription factor AP-2β (TFAP2B) is a differentiation marker, which is expressed in a subpopulation of cells in the human mammary epithelium. In neoplastic breast lesions, TFAP2B is associated with a favorable clinical outcome and in situ and invasive lobular breast cancer. Functional analyses in lobular breast cancer cell lines indicate that TFAP2B controls tumor cell proliferation of this breast cancer subtype.

Mieke Raap, Malte Gronewold, Henriette Christgen, Silke Glage, Mohammad Bentires-Alj, Shany Koren, Patrick W Derksen, Mirjam Boelens, Jos Jonkers, Ulrich Lehmann, Friedrich Feuerhake, Elna Kuehnle, Oleg Gluz, Ronald Kates, Ulrike Nitz, Nadia Harbeck, Hans H Kreipe and Matthias Christgen

2018 98: 117-129; advance online publication, October 16, 2017; 10.1038/labinvest.2017.106

Abstract | Full Text

ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production OPEN

This study investigated the role of resolvin D1 (RvD1) on alveolar epithelial cell function/differentiation and protection against fibroproliferative stimuli. The authors found that RvD1 promotes alveolar epithelial repair by stimulating wound repair and proliferation, reducing apoptosis and inhibiting TGF-β induced epithelial mesenchymal transition. Additionally, RvD1 reduces fibroproliferation, collagen production and myofibroblast differentiation.

Shengxing Zheng, Qian Wang, Vijay D'Souza, Dom Bartis, Rachel Dancer, Dhruv Parekh, Fang Gao, Qingquan Lian, Shengwei Jin and David R Thickett

2018 98: 130-140; advance online publication, October 30, 2017; 10.1038/labinvest.2017.114

Abstract | Full Text


Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine

A strategy to systematically compare human and mouse tissues to identify molecular similarities and differences is presented. This novel approach employs high-throughput tissue microarrays of humans and mice by MALDI-Fourier transform-ion cyclotron resonance-mass spectrometry imaging to spatially resolve mass spectra at the level of specific metabolites, hierarchical clustering and pathway enrichment analysis to identify functionally similar/different molecular patterns in pathological lesions.

Michaela Aichler, Thomas Kunzke, Achim Buck, Na Sun, Maximilian Ackermann, Danny Jonigk, Andreas Gaumann and Axel Walch

2018 98: 141-149; advance online publication, October 16, 2017; 10.1038/labinvest.2017.110

Abstract | Full Text

Technical Report



Rapid virtual hematoxylin and eosin histology of breast tissue specimens using a compact fluorescence nonlinear microscope

Due to a lack of intraoperative margin evaluation tools for breast cancer, up to 40% of patients undergoing breast conserving surgery require repeat surgeries. The authors demonstrate a method for rapid histological evaluation of freshly excised, unfixed breast cancer specimens using nonlinear microscopy with low-cost fiber lasers and extractable fluorescent stains that requires only seconds.

Lucas C Cahill, Michael G Giacomelli, Tadayuki Yoshitake, Hilde Vardeh, Beverly E Faulkner-Jones, James L Connolly, Chi-Kuang Sun and James G Fujimoto

2018 98: 150-160; advance online publication, November 13, 2017; 10.1038/labinvest.2017.116

Abstract | Full Text

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