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EMBO reports Table of Contents for January 2018; Vol. 19, No. 1

January 2018 | Volume 19, Number 1 Submit


Table of Contents

Opinion
News & Views
Science & Society
Review
Scientific Reports
Articles
COVER

Volume 19, Number 1



Opinion
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The use of gene drive to control or eradicate pest and disease vector populations is a highly controversial topic. In order to maintain independence and public trust, scientists need know who is representing whom in this debate.

Christophe Boëte
Published online 15.12.2017

News & Views
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A study in this issue shows that Nup62‐mediated p63 nuclear import controls squamous cell carcinoma proliferation and differentiation and thereby adds data to the recent notion that alterations in nuclear pore complex composition might be utilized to determine cell fate.

Joana Borlido and Maximiliano A D'Angelo
Published online 18.12.2017

Science & Society
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Novel vaccines against substances of abuse generate a strong antibody response that prevents the drug from entering the brain. These could become a safe and efficient tool to combat a growing crisis of opioid abuse.

Margaret E Olson and Kim D Janda
Published online 13.12.2017

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The advent of genomics has revolutionized biomedical research but also generated a glut of PhD thesis stitched together from various publications. While the Frankenthesis is not a new occurrence, it raises questions about structure and content of PhD training.

David Roy Smith
Published online 30.11.2017

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DNA's ability to form Holliday junctions and double cross‐overs can be used to build complex two‐ and three‐dimensional nano‐scale structures for biotechnological applications and high‐precisions electronics.

Philip Hunter
Published online 07.12.2017

Review
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Circadian clocks are evolutionarily conserved timekeepers that adapt cell physiology to diurnal cycles. This review discusses functions of circadian rhythms in stem cells and differentiated tissues, and how clocks influence stem cell maintenance, organ physiology, regeneration, and aging.

Pieterjan Dierickx, Linda W Van Laake and Niels Geijsen
Published online 19.12.2017 Open Access

Scientific Reports
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Mycobacterial uptake into epithelial cell is dependent on the receptor M3R and requires actin rearrangements regulated by Arf1. This pathway is controlled by ArfGAP1, demonstrating its role in the regulation of host‐pathogen interactions.

Ok‐Ryul Song, Christophe J Queval, Raffaella Iantomasi, Vincent Delorme, Sabrina Marion, Romain Veyron‐Churlet, Elisabeth Werkmeister, Michka Popoff, Isabelle Ricard, Samuel Jouny, Nathalie Deboosere, Frank Lafont, Alain Baulard, Edouard Yeramian, Laurent Marsollier, Eik Hoffmann and Priscille Brodin
Published online 15.11.2017

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Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin is protected until anaphase onset. The kinase Haspin phosphorylates Wapl, thereby inhibiting the interaction with Pds5B, and protecting centromeric cohesion.

Cai Liang, Qinfu Chen, Qi Yi, Miao Zhang, Haiyan Yan, Bo Zhang, Linli Zhou, Zhenlei Zhang, Feifei Qi, Sheng Ye and Fangwei Wang
Published online 14.11.2017

Articles
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Under starvation conditions, yeast ER‐vacuole contact sites (NVJs) expand and become a site for lipid droplet (LD) biogenesis. The tethering protein, Mdm1, interacts with fatty acid activating enzymes and promotes NVJ‐associated LD production.

Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J Ryan Feathers and W Mike Henne
Published online 16.11.2017

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Nucleoporin NUP62 promotes p63 nuclear import and SCC proliferation. Epidermal differentiation‐induced ROCK kinase phosphorylates NUP62 and limits p63 nuclear import. This study highlights NUP62 as a gatekeeper for p63 and regulator of SCC cell fate.

Masaharu Hazawa, De‐Chen Lin, Akiko Kobayashi, Yan‐Yi Jiang, Liang Xu, Firli Rahmah Primula Dewi, Mahmoud Shaaban Mohamed, Hartono, Mitsutoshi Nakada, Makiko Meguro‐Horike, Shin‐ichi Horike, H Phillip Koeffler and Richard W Wong
Published online 07.12.2017

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Inflammasomes induce caspase‐1 activation, cytokine production and macrophage pyroptosis upon bacterial infection. GLMN, an inhibitor of RING‐type E3 ligases, targeted by the Shigella effector IpaH7.8, negatively regulates inflammasomes by interfering with cIAP E3 ligase activities.

Shiho Suzuki, Toshihiko Suzuki, Hitomi Mimuro, Tsunehiro Mizushima and Chihiro Sasakawa
Published online 30.11.2017

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Brat controls lineage progression in neural stem cells via coordinated post‐transcriptional suppression of Deadpan (Dpn) and Zelda (Zld). While even low concentrations of Brat can suppress zld, dpn repression requires higher Brat concentrations only achieved in immature intermediate neural progenitors.

Ilka Reichardt, François Bonnay, Victoria Steinmann, Inga Loedige, Thomas R Burkard, Gunter Meister and Juergen A Knoblich
Published online 30.11.2017

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T‐box family transcription factors have emerged as regulators of histone modifications. Here, BRACHYURY is shown to bind p300 and facilitate H3K27ac at target gene loci, including those important for hematopoietic specification.

Arica Beisaw, Pavel Tsaytler, Frederic Koch, Sandra U Schmitz, Maria‐Theodora Melissari, Anna D Senft, Lars Wittler, Tracie Pennimpede, Karol Macura, Bernhard G Herrmann and Phillip Grote
Published online 15.11.2017

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SETDB1 controls EMT of breast epithelial and cancer cells. TGF‐β‐induced SETDB1 recruitment to Smad3 promotes H3K9 methylation and represses Smad3/4‐activated expression of SNAI1, encoding an EMT master regulator.

Dan Du, Yoko Katsuno, Dominique Meyer, Erine H Budi, Si‐Han Chen, Hartmut Koeppen, Hongjun Wang, Rosemary J Akhurst and Rik Derynck
Published online 12.12.2017

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Parathyroid hormone (PTH) causes a ~two–threefold increase in the number of regulatory T cells (Tregs) in humans and mice, an effect which is required for PTH to exert its bone anabolic activity.

Mingcan Yu, Patrizia D'Amelio, Abdul Malik Tyagi, Chiara Vaccaro, Jau‐Yi Li, Emory Hsu, Ilaria Buondonno, Francesca Sassi, Jonathan Adams, M Neale Weitzmann, Richard DiPaolo and Roberto Pacifici
Published online 20.11.2017

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Gram‐negative bacteria produce cyclic glucans, which are components of the bacterial envelope and the periplasm. Periplasmic glucans sequester iron, serving as intracellular iron reservoir, and protecting the bacteria by limiting free iron‐induced toxicity under iron‐replete conditions.

Sreegowrinadh Javvadi, Sheo Shankar Pandey, Amita Mishra, Binod Bihari Pradhan and Subhadeep Chatterjee
Published online 08.12.2017

 
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