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donderdag 7 december 2017

Nature Reviews Endocrinology - Table of Contents alert Volume 14 Issue 1

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Nature Reviews Endocrinology
January 2018 Volume 14 Number 1
Nature Reviews Endocrinology cover
2016 2-year Impact Factor 18.318
Journal Metrics 2-year Median 13
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
Current pharmacotherapy for obesity
Gitanjali Srivastava & Caroline M. Apovian

Recommend to library

Immunotherapy: PDL1 restoration reverses T1DM
Published online: 01 December 2017
p1 | doi:10.1038/nrendo.2017.165


Adipose tissue: Noncanonical beige fat thermogenesis
Published online: 24 November 2017
p2 | doi:10.1038/nrendo.2017.158


Diabetes: Very-low-calorie diet reverses T2DM in rats
Published online: 24 November 2017
p2 | doi:10.1038/nrendo.2017.159


Bone: PPARĪ³ controls marrow adiposity
Published online: 10 November 2017
p3 | doi:10.1038/nrendo.2017.152


Cardiovascular endocrinology: Long-term safety of growth hormone
Published online: 17 November 2017
p3 | doi:10.1038/nrendo.2017.155


In the news
Published online: 01 December 2017
p3 | doi:10.1038/nrendo.2017.164


Metabolism: Metabolic effects of intermeal fasting
Published online: 10 November 2017
p4 | doi:10.1038/nrendo.2017.153


Reproductive endocrinology: Exposure to pesticide residues linked to adverse pregnancy outcomes
Published online: 17 November 2017
p4 | doi:10.1038/nrendo.2017.156



Obesity: Trends in underweight and obesity — scale of the problem
Jack A. Yanovski

Published online: 24 November 2017
p5 | doi:10.1038/nrendo.2017.157

A recent study reports that the global prevalence of paediatric obesity increased to >5% between 1975 and 2016. This increase occurred even as the prevalence of paediatric underweight decreased slightly but remained >8%. These average prevalence changes blur the remarkable regional variations in how prevalence has changed. There is a pressing need to address both underweight and obesity worldwide.
Full Text | PDF

Bone: High-intensity exercise to prevent fractures — risk or gain?
Wolfgang Kemmler & Simon von Stengel

Published online: 10 November 2017
p6 | doi:10.1038/nrendo.2017.148

Although the favourable effects of high-intensity resistance and impact training (HiRIT) on bone strength have been demonstrated, it is generally considered unsuitable for older adults. A recent study reports that 8 months of HiRIT was efficacious and induced no adverse effects in older postmenopausal women with, or at risk of, osteoporosis.
Full Text | PDF

Diabetes: Metformin — a cardiovascular moderator of DPP4 inhibitors?
Andre J. Scheen

Published online: 24 November 2017
p8 | doi:10.1038/nrendo.2017.154

Three cardiovascular outcome trials failed to show superiority of DPP4 inhibitors compared with placebo in patients with type 2 diabetes mellitus and high cardiovascular risk, a rather disappointing finding. Now, a post hoc subgroup analysis suggests that patients treated with metformin at baseline might benefit from DPP4 inhibitors in contrast with metformin non-users.
Full Text | PDF

Thyroid cancer: CAR T cell therapy — potential in advanced thyroid cancer?
Jena D. French & Bryan R. Haugen

Published online: 24 November 2017
p10 | doi:10.1038/nrendo.2017.160

In the current era of immunotherapy successes, Min and colleagues report the promising preclinical development and efficacy of a CAR T cell therapy that recognizes ICAM-1, which is highly expressed in advanced thyroid cancers. Herein, we discuss the feasibility of this approach and its implications for future therapies to treat thyroid cancer.
Full Text | PDF

Current pharmacotherapy for obesity
Gitanjali Srivastava & Caroline M. Apovian

Published online: 13 October 2017
p12 | doi:10.1038/nrendo.2017.122

As not all individuals with obesity respond to lifestyle modification, pharmacotherapy has a key role in tackling the obesity epidemic. Here, Gitanjali Srivastava and Caroline Apovian review the six currently available FDA-approved anti-obesity drugs in terms of safety, efficacy and clinical utility.
Abstract | Full Text | PDF

The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus
Jerome Clasadonte & Vincent Prevot

Published online: 27 October 2017
p25 | doi:10.1038/nrendo.2017.124

The hypothalamus is the main integrator of endocrine regulation. Glia-neuron interactions contribute to physiological processes such as puberty, the maintenance of bodily homeostasis and ageing. Here, Vincent Prevot and Jerome Clasadonte discuss glia-neuron interactions in the control of hypothalamic neuroendocrine function.
Abstract | Full Text | PDF

Reversing the tide — diagnosis and prevention of T2DM in populations of African descent
Jean N. Utumatwishima et al.

Published online: 23 October 2017
p45 | doi:10.1038/nrendo.2017.127

Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). Here, Anne Sumner and colleagues discuss issues related to the diagnosis and prevention of T2DM in these populations, including screening test efficacy, prevention strategies and the relative paucity of genomic data.
Abstract | Full Text | PDF | Supplementary information

Chronic endocrine consequences of traumatic brain injury — what is the evidence?
Marianne Klose & Ulla Feldt-Rasmussen

Published online: 08 September 2017
p57 | doi:10.1038/nrendo.2017.103

In this Opinion article, Klose and Feldt-Rasmussen posit that the true risk and disease burden of hypopituitarism after traumatic brain injury might have been overestimated in recent years. Possible reasons for this overestimation are discussed, along with current recommendations for diagnosing and treating the condition.
Abstract | Full Text | PDF

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