We bring you the latest news from the healthcare about the health care in the United Kingdom.

maandag 11 december 2017

Nature Biotechnology Contents: Volume 35 pp 1113 - 1216

If you are unable to see the message below, click here to view.
Nature Biotechnology

Advertisement
Signal for easy to use phosphorylation assays 
TABLE OF CONTENTS

December 2017 Volume 35, Issue 12

Editorial
News
Correction
Bioentrepreneur
Opinion and Comment
Features
News and Views
Research
Corrigenda
Erratum
Careers and Recruitment
 
Advertisement
 
Discover a new path to your success via Human Data Science. IMS Health and Quintiles are now IQVIA™ - created to advance your pursuits of human science by unleashing the power of data science and human ingenuity. We are here to help you find solutions to drive healthcare forward.

Join the journey today.

 
Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
 

Advertisement
Are you up for a challenge?

The Merck Innovation Cup is your chance to join international graduate students & postdoctoral researchers for a week-long innovation camp. Learn about industrial research & development, network with professionals and win $20,000 team prize. All expenses paid by Merck.

Take up the challenge & apply now at innovationcup.merckgroup.com
 
Advertisement

BIOPHARMA DEALMAKERS
BIOPHARMA DEALMAKERSCompany Profiles and Partnering Opportunities

 
Advertisement
Nature Index 2017: Innovation

The Nature Index Innovation supplement examines the link between high-quality research and the commercialization of products and services, with particular focus on scientific discoveries and its economic potential.

Read the full supplement free for six months
 
 

Advertisement
Nature Outlook: Blood 

Blood is the epicentre of much biomedical research, from fighting disease to creating artificial substitutes for this vital fluid. This Outlook discusses topics such as a gene-editing treatment for sickle-cell disease and keeping the blood supply safe from pathogens. 

Get free access 
Produced with support from: Grifols 
 

Editorial

Top

Methods, preprints and papers   p1113
doi:10.1038/nbt.4044
This journal supports preprints as a means to rapidly share research, but discourages their use as stand-alone citations disclosing a new method integral to the key results in a paper.
 

News

Top

Ablynx's nanobody fragments go places antibodies cannot   pp1115 - 1117
Cormac Sheridan
doi:10.1038/nbt1217-1115
 

Amgen cholesterol antibody feud could kill key IP rule   pp1118 - 1119
Mark Ratner
doi:10.1038/nbt1217-1118
 

California cracks down on stem cell cowboys   p1119
Laura DeFrancesco
doi:10.1038/nbt1217-1119
 

A new crop of microbe startups raises big bucks, takes on the establishment   pp1120 - 1122
Emily Waltz
doi:10.1038/nbt1217-1120
 

Around the world in a month   p1122
doi:10.1038/nbt1217-1122
 

The Broad and Johns Hopkins lure deep-pocketed investors   p1123
Eva von Schaper
doi:10.1038/nbt1217-1123
 

Activists bury India's GM mustard hopes   p1124
Killugudi Jayaraman
doi:10.1038/nbt1217-1124a
 

Correction

Top

Corrections   p1124
doi:10.1038/nbt1217-1124b
 

News

Top
Data Page

Drug pipeline 3Q17   p1125
Laura DeFrancesco
doi:10.1038/nbt.4032
 

Profile DNA, RNA, protein, and phospho-protein targets up to 800-plex from a single sample. With curated content for specific research areas, including Immuno-Oncology, Solid Tumor, and Heme Profiling, get more data from less sample. 

Learn more about 3D Biology™ Technology

Bioentrepreneur

Top
Data Page

Top 20 translational researchers of 2016   p1126
Brady Huggett and Kathryn Paisner
doi:10.1038/nbt.4028
 

Opinion and Comment

Top
Correspondence

The international MAQC Society launches to enhance reproducibility of high-throughput technologies   pp1127 - 1128
Leming Shi, Rebecca Kusko, Russell D Wolfinger, Benjamin Haibe-Kains, Matthias Fischer et al.
doi:10.1038/nbt.4029
 

Challenges and recommendations for epigenomics in precision health   pp1128 - 1132
Ava C Carter, Howard Y Chang, George Church, Ashley Dombkowski, Joseph R Ecker et al.
doi:10.1038/nbt.4030
 

Characterize the epitope landscape of your entire antibody library at the earliest stages of discovery to make smart decisions:
  • Maximize epitope diversity
  • Identify unique epitopes
  • Build your IP portfolio

Learn about the rapid assessment of an antibody library's epitopic diversity by reading this application note.

Download the Application Note >>

 

 
 

Features

Top

When pig organs will fly   pp1133 - 1138
Emily Waltz
doi:10.1038/nbt.4027
Regulators, scientists and surgeons are preparing the groundwork for human trials of engineered pig organs[mdash]and industry is starting to take notice.
 

Patents

Will inter partes review speed US generic drug entry?   pp1139 - 1141
Jonathan J Darrow, Reed F Beall and Aaron S Kesselheim
doi:10.1038/nbt.4036
A new extra-judicial pathway for challenging pharmaceutical patents has intensified patent challenges and helped to clear the way for earlier generic entry.
 

Recent patents in xenotransplantation   p1142
doi:10.1038/nbt.4040
 

News and Views

Top

DNA sequencing at ultra-high fidelity   pp1143 - 1144
Robert Sebra
doi:10.1038/nbt.4001
Built-in error-correction and novel fluorogenic chemistry open a path to perfect read quality.

See also: Research by Chen et al.

Tuning up T-cell receptors   pp1145 - 1146
C Garrett Rappazzo and Michael E Birnbaum
doi:10.1038/nbt.4009
T-cell receptors with higher affinity for tumor antigens are discovered by harnessing T-cell development.

See also: Research by Schmitt et al.

Research Highlights   p1146
doi:10.1038/nbt.4031
 

MAGE in yeast is a go   pp1147 - 1148
Susan Jones
doi:10.1038/nbt.4033
 

Biotechnology
JOBS of the week
Posdoctoral position
CNRS & Bordeaux University
Postdoctoral Research Scientist / Fellow
Columbia University
Program Officer, Crohn's Disease
The Leona M. and Harry B. Helmsley Charitable Trust
Faculty Positions
Thomas Jefferson University (TJU)
Associate Editor at Genome Research
Cold Spring Harbor Laboratory (CSHL)
More Science jobs from

Research

Top
Perspective

Just how good an investment is the biopharmaceutical sector?   pp1149 - 1157
Richard T Thakor, Nicholas Anaya, Yuwei Zhang, Christian Vilanilam, Kien Wei Siah et al.
doi:10.1038/nbt.4023
An analysis of biotech and pharma stock prices since 1930 reveals sharp differences in the risk-adjusted returns of the two sectors.
 

Review

Microbial synthesis of medium-chain chemicals from renewables   pp1158 - 1166
Stephen Sarria, Nicholas S Kruyer and Pamela Peralta-Yahya
doi:10.1038/nbt.4022
Strategies to engineer microorganisms to produce medium-chain hydrocarbon chemicals are reviewed.
 

Brief Communications

Accurate assembly of transcripts through phase-preserving graph decomposition   pp1167 - 1169
Mingfu Shao and Carl Kingsford
doi:10.1038/nbt.4020
Scallop improves identification of multi-exon and transcripts expressed at low levels by retaining phasing information during assembly.
 

Articles

Highly accurate fluorogenic DNA sequencing with information theory-based error correction   pp1170 - 1178
Zitian Chen, Wenxiong Zhou, Shuo Qiao, Li Kang, Haifeng Duan et al.
doi:10.1038/nbt.3982
The error rate of DNA sequencing is much reduced by combining an improved fluorogenic sequencing chemistry with a new error-correction scheme.

See also: News and Views by Sebra

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing   pp1179 - 1187
Hao Yin, Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh et al.
doi:10.1038/nbt.4005
Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.
 

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro    pp1188 - 1195
Thomas M Schmitt, David H Aggen, Kumiko Ishida-Tsubota, Sebastian Ochsenreither, David M Kranz et al.
doi:10.1038/nbt.4004
The affinity of T cells for tumor self-antigens is improved by a culture system that identifies optimal T-cell-receptor B chains.

See also: News and Views by Rappazzo & Birnbaum

Letter

Cell-type-specific metabolic labeling of nascent proteomes in vivo    pp1196 - 1201
Beatriz Alvarez-Castelao, Christoph T Schanzenbacher, Cyril Hanus, Caspar Glock, Susanne tom Dieck et al.
doi:10.1038/nbt.4016
Proteomes of distinct cell types in the brains of live mice are labeled and quantitated with a genetically encoded non-canonical amino-acid labeling method and click chemistry.
 

Resources

Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules   pp1202 - 1210
Daniel L Coutu, Konstantinos D Kokkaliaris, Leo Kunz and Timm Schroeder
doi:10.1038/nbt.4006
A compendium detailing the localization of bone and bone-marrow-microenvironment cells and proteins will enable efforts to understand the functions of this niche.
 

Careers and Recruitment

Top

Institutional culture is the key to team science   pp1212 - 1214
Sandra Soo-Jin Lee and Anna Jabloner
doi:10.1038/nbt.4026
Institutional leadership in creating a culture of cooperation and pathways for multidisciplinary collaboration is critical to achieving the goals of academic translation and innovation.
 

People

People   p1216
doi:10.1038/nbt.4041
 

Corrigenda

Top

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis   p1211
Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian et al.
doi:10.1038/nbt1217-1211a
 

Corrigendum: Shotgun metagenomics, from sampling to analysis   p1211
Christopher Quince, Alan W Walker, Jared T Simpson, Nicholas J Loman and Nicola Segata
doi:10.1038/nbt1217-1211b
 

Corrigendum: Development and function of human innate immune cells in a humanized mouse model   p1211
Anthony Rongvaux, Tim Willinger, Jan Martinek, Till Strowig, Sofia V Gearty et al.
doi:10.1038/nbt1217-1211c
 

Erratum

Top

Erratum: Revisiting the Warnock rule   p1211
J Benjamin Hurlbut, Insoo Hyun, Aaron D Levine, Robin Lovell-Badge, Jeantine E Lunshof et al.
doi:10.1038/nbt1217-1211d
 

Advertisement
Do you have a career question? 

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today!
 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature