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woensdag 15 november 2017

Nature Reviews Nephrology - Table of Contents alert Volume 13 Issue 12

Nature Reviews Nephrology

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December 2017 Volume 13 Number 12
Nature Reviews Nephrology cover
2016 2-year Impact Factor 12.146 Journal Metrics 2-year Median 9
In this issue
Research Highlights
News and Views
Also this month
 Featured article:
Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery
Michael L. Merchant, Ilse M. Rood, Jeroen K. J. Deegens & Jon B. Klein


Recommend to library

Renal physiology: ER-associated degradation in diabetes insipidus
Published online: 09 October 2017
p721 | doi:10.1038/nrneph.2017.144


Renal anaemia: iPSC-derived EPO-producing cells rescue anaemia
Published online: 16 October 2017
p722 | doi:10.1038/nrneph.2017.146


Genetic kidney disease: Uromodulin in ER stress and apoptosis
Published online: 30 October 2017
p722 | doi:10.1038/nrneph.2017.152


Podocytes: ShcA regulates nephrin turnover
Published online: 30 October 2017
p722 | doi:10.1038/nrneph.2017.153


Polycystic kidney disease: Modulation of cystogenesis by the microenviroment
Published online: 16 October 2017
p723 | doi:10.1038/nrneph.2017.147


Developmental biology: Renewal of NPCs requires MYC and β-catenin
Published online: 30 October 2017
p723 | doi:10.1038/nrneph.2017.151



Nature Reviews Nephrology
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Hypertension: Device therapy for uncontrolled hypertension: new approaches to an old problem
Peter J. Blankestijn & Michiel L. Bots

Published online: 15 November 2017
p725 | doi:10.1038/nrneph.2017.150

Uncontrolled hypertension is an important clinical problem and is associated with considerable morbidity and mortality. A new report from the SPYRAL HTN-OFF MED researchers, which describes the use of renal denervation in patients with uncontrolled hypertension, might reignite enthusiasm for this technique, while a first-in-human description of endovascular baroreflex amplification from the CALM-FIM_EUR investigators highlights the potential of this new approach to inhibit sympathetic activity.
Full Text | PDF

Immunometabolism: Oxygen sensing and cell metabolism in inflammation
Kai-Uwe Eckardt

Published online: 24 October 2017
p727 | doi:10.1038/nrneph.2017.145

Hypoxia-inducible transcription factors (HIFs) are key mediators of several molecular and cellular responses that are activated under hypoxic conditions. New findings demonstrate an important role for the HIF system in mediating the activation and inflammatory responses of neutrophils through tight interaction with their glucose metabolism.
Full Text | PDF

Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors
Berthold Hocher & Oleg Tsuprykov

Published online: 09 October 2017
p728 | doi:10.1038/nrneph.2017.140

New data from the LEADER trial show that the glucagon-like peptide 1 receptor agonist liraglutide protects against diabetic nephropathy in patients with type 2 diabetes mellitus. The renoprotective efficacy of liraglutide is not, however, as great as that reported for the sodium-glucose cotransporter 2 inhibitor emplagiflozin in the EMPA-REG OUTCOME trial.
Full Text | PDF

Nature Reviews Collection — The obesity epidemic: molecular and clinical considerations 

This collection of articles describes the latest efforts to understand the molecular mechanisms underlying obesity against a complex backdrop of factors that include socioeconomic status, environment and personal behaviour, as well as advances in treatment. 

View the collection
Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery
Michael L. Merchant, Ilse M. Rood, Jeroen K. J. Deegens & Jon B. Klein

Published online: 30 October 2017
p731 | doi:10.1038/nrneph.2017.148

Extracellular vesicles in the urine have potential as disease biomarkers. This Review discusses the different types of extracellular vesicles and the optimization of approaches to enable their isolation and purification, and to characterize their composition by high-throughput 'omics' technologies.
Abstract | Full Text | PDF

New treatment paradigms for ADPKD: moving towards precision medicine
Matthew B. Lanktree & Arlene B. Chapman

Published online: 09 October 2017
p750 | doi:10.1038/nrneph.2017.127

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development, variable kidney function decline and variable presentation of renal and extrarenal manifestations. In this Review, the authors discuss pharmacological and non-pharmacological interventions for the treatment of patients with ADPKD and provide recommendations for the management of renal complications.
Abstract | Full Text | PDF

CD36 in chronic kidney disease: novel insights and therapeutic opportunities
Xiaochun Yang, Daryl M. Okamura, Xifeng Lu, Yaxi Chen, John Moorhead, Zac Varghese & Xiong Z. Ruan

Published online: 18 September 2017
p769 | doi:10.1038/nrneph.2017.126

CD36 has important roles in lipid homeostasis, metabolic inflammation, reprogramming of energy metabolism, apoptosis and kidney fibrosis. Here, the authors discuss these roles as well as the regulation and post-translational modification of CD36 and its potential as a biomarker and a therapeutic target for kidney disease.
Abstract | Full Text | PDF

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Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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