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Nature Reviews Genetics Contents December 2017 Volume 18 Number 12 pp 701-760

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Nature Reviews Genetics

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Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights

Also this month
Article series:
Study designs
Disease mechanisms
 Featured article:
Beyond editing to writing large genomes
Raj Chari & George M. Church


A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine.

Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research.

Open for submissions >>>

Recommend to library
Animation on CRISPR: Gene editing and beyond

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next.

Watch the Animation here>>

Produced with support from: 
Nature Outlook: Women’s health 

From common diseases that affect the sexes differently to conditions that affect only women — and from birth, through the menopause, to old age — there are many challenges in women’s health.

Access the Outlook free online to learn more >>

Produced with support from: Symbiomix Therapeutics, LLC
npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine.

The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.
Explore the benefits of submitting your manuscript

Gene expression: Principles of gene regulation across tissues
p701 | doi:10.1038/nrg.2017.94

Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation
p702 | doi:10.1038/nrg.2017.87

Transcription: Intragenic enhancers dampen gene expression
p702 | doi:10.1038/nrg.2017.90

Cancer genomics: The driving force of cancer evolution
p703 | doi:10.1038/nrg.2017.95

Genetic engineering: On the road to efficient gene drives
p704 | doi:10.1038/nrg.2017.91

Transcription: Promoters dictate termination mode
p704 | doi:10.1038/nrg.2017.93


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Demographic history, selection and functional diversity of the canine genome
Elaine A. Ostrander, Robert K. Wayne, Adam H. Freedman & Brian W. Davis

p705 | doi:10.1038/nrg.2017.67
Despite being a single species, dogs represent nearly 400 breeds with substantial genetic, morphological and behavioural diversity. In this Review, Ostrander et al. discuss how genomics studies of dogs have enhanced our understanding of dog and human population history, the desired and unintended consequences of trait-based selective breeding, and potentially human-applicable insights into cancer, ageing, behaviour and neurological diseases.
Abstract | Full Text | PDF

Population genetics of sexual conflict in the genomic era
Judith E. Mank

p721 | doi:10.1038/nrg.2017.83
Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved.
Abstract | Full Text | PDF

Article series: Disease mechanisms
Convergence between biological, behavioural and genetic determinants of obesity
Sujoy Ghosh & Claude Bouchard

p731 | doi:10.1038/nrg.2017.72
Recent large-scale genome-wide association studies have identified numerous variants that are associated with obesity-relevant traits such as body mass index or body fat percentage. Here, the authors explore to what extent this genomic evidence matches the evidence from functional and mechanistic studies.
Abstract | Full Text | PDF | Supplementary information
Nature Reviews Collection — The obesity epidemic: molecular and clinical considerations 

This collection of articles describes the latest efforts to understand the molecular mechanisms underlying obesity against a complex backdrop of factors that include socioeconomic status, environment and personal behaviour, as well as advances in treatment. 

View the collection
Article series: Study designs
Beyond editing to writing large genomes
Raj Chari & George M. Church

p749 | doi:10.1038/nrg.2017.59
Advances in genome sequencing, editing and synthetic biology have enhanced the feasibility of large-scale genome engineering, termed genome writing. In this Opinion article, Chari and Church discuss the strengths and limitations of diverse strategies for genome writing, including extensively modifying existing genomes versus synthesizing genomes de novo, and they provide future visions for writing large genomes.
Abstract | Full Text | PDF

Nature Reviews Disease Primers — Stay updated 

Nature Reviews Disease Primers covers all medical specialties, already having published on more than 120 diseases and disorders since launching in 2015. With such a comprehensive article collection, our e-alerts are the perfect solution to stay updated on the latest content published by the journal. 

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