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dinsdag 28 november 2017

Nature Reviews Drug Discovery contents December 2017 Volume 16 Number 12 pp 811-883

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Nature Reviews Drug Discovery
 

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TABLE OF CONTENTS
 
December 2017 Volume 16 Number 12 Advertisement
 
Nature Reviews Drug Discovery cover
2016 2-year Impact Factor 57.000 Journal Metrics 2-year Median 38
In this issue
Comment
News and Analysis
Research Highlights
Analysis
Reviews
 
Also this month
 Featured article:
Tau-based therapies in neurodegeneration: opportunities and challenges
Chuanzhou Li & Jürgen Götz

 
 

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Comment: Legacy data sharing to improve drug safety assessment: the eTOX project
Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K. Watson, Thomas Kleinöder, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J. Brookes, Søren Brunak, Mark T. D. Cronin, Gerhard F. Ecker, Sylvia Escher, Nigel Greene, Antonio Guzmán, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P. E. Vermeulen, Esther Vock, Gerhard Wolber & Ismael Zamora

p811 | doi:10.1038/nrd.2017.177
The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through the Innovative Medicines Initiative to explore this possibility.
Abstract | Full Text | PDF | Supplementary information

 
 
NEWS AND ANALYSIS
 
Top
Small molecules against RNA targets attract big backers
Asher Mullard

p813 | doi:10.1038/nrd.2017.239
Novartis, Merck, Pfizer and biotech entrepreneurs have started working on small-molecule drugs that act on an assortment of RNA targets, hoping to unlock once undruggable targets and new biology.
PDF
 
Cryo-electron microscopy makes waves in pharma labs
Mark Peplow

p815 | doi:10.1038/nrd.2017.240
Companies hope the Nobel Prize-winning imaging methodology will reveal biomolecule characteristics that can guide drug discovery projects.
PDF
 
NEWS IN BRIEF
FDA approves first digital pill
Asher Mullard

p818 | doi:10.1038/nrd.2017.248
PDF
 
Second anticancer CAR T therapy receives FDA approval
Asher Mullard

p818 | doi:10.1038/nrd.2017.249
PDF
 
BTK inhibitors get a boost
Asher Mullard

p818 | doi:10.1038/nrd.2017.250
PDF
 
BIOBUSINESS BRIEFS
Trial watch: Tracing investment in drug development for Alzheimer disease
Alpha Tom Kodamullil, Firas Zekri, Meemansa Sood, Bastian Hengerer, Luc Canard, Duncan McHale & Martin Hofmann-Apitius

p819 | doi:10.1038/nrd.2017.169
PDF
 
AN AUDIENCE WITH
Eric Rubin
p820 | doi:10.1038/nrd.2017.228
Eric Rubin, vice president of clinical oncology at Merck & Co, discusses tumour-agnostic approvals, immunotherapy combinations and the modernization of clinical trial eligibility criteria.
PDF
 
FROM THE ANALYST'S COUCH
The human microbiome: opportunity or hype?
Pedro M. Valencia, Magali Richard, Jesse Brock & Elsy Boglioli

p823 | doi:10.1038/nrd.2017.154
This article discusses investment in microbiome-based therapeutic approaches and key questions for the field related to the underlying science, clinical development, regulation and business models.
PDF
 
RESEARCH HIGHLIGHTS
 
Top

Sepsis: Stalking a new target
p825 | doi:10.1038/nrd.2017.238
PDF


Metabolic disease: Ectopic olfactory receptor activation reverses obesity
p826 | doi:10.1038/nrd.2017.230
PDF


Cancer: Bispecific antibody directs T cells to solid tumours
p826 | doi:10.1038/nrd.2017.237
PDF


Obesity: GDF15 tells the brain to lose weight
p827 | doi:10.1038/nrd.2017.241
PDF


Cancer immunotherapy: Rewiring cancer cells
p828 | doi:10.1038/nrd.2017.242
PDF


 


IN BRIEF

Polypharmacology: Repurposing ceritinib | Infectious disease: Fighting influenza B | Diabetes: Selective FOXO1 modulation | GPCRs: Crystal structure of D4 dopamine receptor
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Drug Discovery
JOBS of the week
Principal Scientist in Cellular Pharmacology
Johnson & Johnson
MRC WIMM Prize PhD Studentships
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ANALYSIS
 
Top
Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser, Misty M. Attwood, Mathias Rask-Andersen, Helgi B. Schiöth & David E. Gloriam

p829 | doi:10.1038/nrd.2017.178
G protein-coupled receptors (GPCRs) are the most intensively studied class of drug targets. This article presents a pioneering analysis of all GPCR-targeted drugs and agents that are currently in clinical trials, and discusses the trends across molecule types, drug targets and therapeutic indications.
Abstract | Full Text | PDF
 
 
 
REVIEWS
 
Top
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Daniella M. Schwartz, Yuka Kanno, Alejandro Villarino, Michael Ward, Massimo Gadina & John J. O'Shea

p843 | doi:10.1038/nrd.2017.201
Janus kinases (JAKs) are essential signalling mediators downstream of many pro-inflammatory cytokines. Jakinibs — small-molecule inhibitors of JAKs — have gained traction as safe and efficacious options for the treatment of inflammation-driven pathologies. This Review discusses the biology, development and efficacy of jakinibs in the treatment of immune and inflammatory diseases.
Abstract | Full Text | PDF

 
Tau-based therapies in neurodegeneration: opportunities and challenges
Chuanzhou Li & Jurgen Gotz

p863 | doi:10.1038/nrd.2017.155
Aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative disorders, including Alzheimer disease (AD). Given the recent failures of several amyloid-β-targeted therapies for AD, interest is growing in tau as an alternative target, and this Review describes preclinical and clinical studies of tau-based approaches in the light of recent advances in the understanding of the physiological and pathological roles of tau.
Abstract | Full Text | PDF

 
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