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zaterdag 21 oktober 2017

The Lancet: [Articles] Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Dete...

[Articles] Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study
The PanCan model was effective in identifying individuals who were subsequently diagnosed with early, potentially curable, lung cancer. The incidence of cancers detected and the proportion of early stage cancers in the screened population was higher than observed in previous studies. This approach should be considered for adoption in lung cancer screening programmes.
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[Comment] Lung cancer screening and its continuous risk assessment
After decades of relatively unsuccessful attempts to improve survival for patients with lung cancer, CT screening has changed the scene. After publication of the results from a pioneering non-randomised pilot study,1 one large-scale randomised controlled trial in the USA and seven European randomised controlled trials were designed to investigate whether earlier detection of lung cancer—made possible primarily by following up after detection of a high quantity of CT-visible pulmonary nodules in high-risk people, which had not yet given rise to complaints—could be followed by earlier, more effective treatment.
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[News] 49th SIOP Congress
Nobuko Hijiya (Children's Hospital of Chicago, Chicago, IL, USA) presented results from a phase 2 study of 58 patients aged 1–18 years with chronic myeloid leukaemia treated with oral nilotinib (230 mg/m2 twice a day) in 28-day cycles. Of 33 patients who had previously received imatinib or dasatinib, 13 (39·4%, 95% CI 22·9–57·9) achieved a major molecular response after six cycles of treatment. Median molecular response was achieved in 16 (64·0%; 95% CI 42·5–82·0) of 25 treatment-naive patients after 12 cycles of treatment.
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[News] Rising cancer drug costs in the USA
The price of patented cancer drugs in the USA rises steadily after their launch, according to a study by Noa Gordon (Rabin Medical Centre, Petah Tikva, Israel) and colleagues. The researchers calculated the monthly, annual, and cumulative changes in the cost of 24 patented injectable cancer medications that obtained US Food and Drug Administration (FDA) approval between 1996 and 2012.
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[News] UK radiologist staffing crisis reaches critical levels
An endemic staffing shortage in UK radiology is causing delays in hospital diagnoses scan assessment results, and wasting millions of the NHS budget, according to official figures released last week.
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