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vrijdag 18 augustus 2017

The Lancet: [Articles] Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a mul...

[Articles] Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
Substantiating the results of the interim analyses of KEYNOTE-006, pembrolizumab continued to provide superior overall survival versus ipilimumab, with no difference between pembrolizumab dosing schedules. These conclusions further support the use of pembrolizumab as a standard of care for advanced melanoma.
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[Comment] KEYNOTE-006: a success in melanoma, but a long way to go
A breakthrough in cancer therapy was achieved by the introduction of immune checkpoint inhibition, starting with the US Food and Drug Administration approval of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4)-specific antibody ipilimumab in 2011.1,2 Since then, clinical experience indicates that only around 20% of patients with late-stage melanoma experience durable responses with ipilimumab, but can pay a high price in terms of adverse events, because ipilimumab has been associated with autoimmune reactions like colitis that can require treatment discontinuation.
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[Articles] Penile allotransplantation for penis amputation following ritual circumcision: a case report with 24 months of follow-up
Penile transplantation restored normal physiological functions in this transplant recipient without major complications in the first 24 months.
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[Comment] Penile transplantation is here
Despite high initial mortality, the development of immunosuppressants has allowed solid organ transplantation to become a mainstay of modern medicine, providing a near cure for otherwise fatal conditions. Life-enhancing vascularised composite allotransplantation (VCA), such as face or hand transplantation, has increasingly been used to successfully treat devastating tissue loss. Results from a recent survey suggest that public attitudes in the USA are favourable overall towards the use of VCA, although concerns remain about seeing familiar body parts on the donor recipient, psychological discomfort, identity loss, and the need for lifelong immunosuppression to treat a non-life-threatening disease.
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[Department of Error] Department of Error
Loewenberg S. Treating and preventing cholera in Bangladesh. Lancet 2017; 390: 637–38—This piece benefited from external funding from the European Journalism Centre via its Innovation in Development Reporting Grant Programme, which should have been declared. This information was added to the online version as of August 17, 2017.
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