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woensdag 23 augustus 2017

Nature Reviews Rheumatology - Table of Contents alert Volume 13 Issue 9

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Nature Reviews Rheumatology  
September 2017 Volume 13 Number 9
Nature Reviews Rheumatology cover
2016 2-year Impact Factor 12.188 Journal Metrics 2-year Median 7
Research Highlights
News and Views
Consensus Statement
Also this month
 Featured article:
Antigen-specific immunotherapies in rheumatic diseases
Judit Pozsgay, Zoltán Szekanecz & Gabriella Sármay


Recommend to library

Inflammation: Resolving — rather than suppressing — inflammation in RA might be the answer
Published online: 27 July 2017
p511 | doi:10.1038/nrrheum.2017.120


Vasculitis syndromes: Notch one up for the endothelium
Published online: 10 August 2017
p512 | doi:10.1038/nrrheum.2017.133


Rheumatoid arthritis: JAK-ing up inadequate RA therapy
Published online: 06 July 2017
p513 | doi:10.1038/nrrheum.2017.114


Systemic lupus erythematosus: A repertoire for disaster
Published online: 20 July 2017
p513 | doi:10.1038/nrrheum.2017.121


Spondyloarthritis: Reinforcing 'treat to target' for SpA
Published online: 03 August 2017
p514 | doi:10.1038/nrrheum.2017.122


Rheumatoid arthritis: Regulating the osteoclast workforce
Published online: 03 August 2017
p514 | doi:10.1038/nrrheum.2017.129




Osteoporosis: Romosozumab versus teriparatide | Rheumatoid arthritis: ACPA-specific synovial immunophenotypes | Osteoarthritis: Matrix turnover linked to dietary weight loss | Experimental arthritis: PUMA reduces inflammation in arthritic joints

Nature Reviews Rheumatology
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Surgery: Falling out of love with knee arthroscopy
Teppo L. N. Järvinen & Gordon H. Guyatt

Published online: 06 July 2017
p515 | doi:10.1038/nrrheum.2017.106

Knee arthroscopy, the most common orthopaedic procedure, is used to treat middle-aged or elderly patients with knee pain, with over two million patients undergoing this surgery every year worldwide. A new clinical practice guideline advises against the use of arthroscopy in these patients, contradicting the common use of this procedure in clinical practice.
Full Text | PDF

Regenerative medicine: Breaking Prometheus's curse for cartilage regeneration
Florence Apparailly

Published online: 27 July 2017
p516 | doi:10.1038/nrrheum.2017.116

Like the mythical eagle devouring Prometheus's liver as fast as it regrew, chronic inflammation hinders cartilage regeneration in inflammatory arthritis. Using stem cells engineered to secrete anti-inflammatory molecules in response to local inflammatory factors could provide a way to keep the eagle at bay as the stem cells differentiate into chondrocytes.
Full Text | PDF

Vasculitis: Mepolizumab for eosinophilic granulomatosis with polyangiitis
Loïc Guillevin

Published online: 03 August 2017
p518 | doi:10.1038/nrrheum.2017.117

Targeting IL-5 could improve outcomes and have steroid-sparing effects in the management of eosinophilic granulomatosis with polyangiitis. However, some questions remain about how this approach affects specific aspects of the disease.
Full Text | PDF

Osteoarthritis: Time to put steroid injections behind us?
Henning Bliddal & Marius Henriksen

Published online: 27 July 2017
p519 | doi:10.1038/nrrheum.2017.118

Intra-articular corticosteroid injections are a long-established treatment for knee osteoarthritis (OA), but new findings indicate they are not effective, and even potentially harmful. Is it time to rethink the use of this treatment?
Full Text | PDF

Pain management: Opioids for RA: a clinical dilemma
Winfried Häuser & Mary-Ann Fitzcharles

Published online: 03 August 2017
p521 | doi:10.1038/nrrheum.2017.123

Opioids provide some modest pain relief for patients with rheumatoid arthritis, but prescription of these drugs is influenced by their association with risks for the individual and for society. Is denial of a treatment, even if that treatment is imperfect, justified when patients experience considerable pain and other treatment options are limited?
Full Text | PDF

Regenerative medicine: Cartilage stem cells identified, but can they heal?
Andrei S. Chagin & Ekaterina V. Medvedeva

Published online: 10 August 2017
p522 | doi:10.1038/nrrheum.2017.127

Regeneration of articular cartilage has been a long-standing challenge in the field of regenerative medicine. In the past 2 years, several studies have genetically identified the presence of stem cells in the surface of articular cartilage, but questions remain as to the healing properties of these cells.
Full Text | PDF

Antigen-specific immunotherapies in rheumatic diseases
Judit Pozsgay, Zoltán Szekanecz & Gabriella Sármay

Published online: 13 July 2017
p525 | doi:10.1038/nrrheum.2017.107

Antigen-specific immunotherapies (ASIs) aim to modulate autoreactive cells and/or induce immune tolerance to self-antigens, and have the potential to be used in the treatment of rheumatic diseases. This Review summarizes current strategies for ASIs, progress in applying these strategies to rheumatic diseases and their limitations and future prospects.
Abstract | Full Text | PDF

The complement system as a potential therapeutic target in rheumatic disease
Leendert A. Trouw, Matthew C. Pickering & Anna M. Blom

Published online: 10 August 2017
p538 | doi:10.1038/nrrheum.2017.125

In this review, the authors evaluate the association of complement activation with a variety of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus and small-vessel vascultis, and discuss whether complement inhibition has therapeutic potential in these diseases.
Abstract | Full Text | PDF

Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances
Savino Sciascia, Mary-Carmen Amigo, Dario Roccatello & Munther Khamashta

Published online: 03 August 2017
p548 | doi:10.1038/nrrheum.2017.124

The range of clinical manifestations and autoantibodies that are recognized as important in antiphosphlipid syndrome (APS) is constantly increasing. How can disease manifestations and autoantibodies that fall outside of the classic APS criteria be incorporated into diagnosis in the future?
Abstract | Full Text | PDF

Discordant American College of Physicians and international rheumatology guidelines for gout management: consensus statement of the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)
Nicola Dalbeth, Thomas Bardin, Michael Doherty, Frédéric Lioté, Pascal Richette, Kenneth G. Saag, Alexander K. So, Lisa K. Stamp, Hyon K. Choi & Robert Terkeltaub

Published online: 10 August 2017
p561 | doi:10.1038/nrrheum.2017.126

In this Consensus Statement, an expert panel compares and contrasts recommendations for the management of gout produced by rheumatology organizations and the American College of Physicians (ACP), and present the G-CAN position on the ACP guideline.

Abstract | Full Text | PDF
Matrix turnover linked to dietary weight loss
Dario Ummarino

Published online: 23 August 2017
p568 | doi:10.1038/nrrheum.2017.143

Full Text | PDF
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Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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