We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

woensdag 23 augustus 2017

Nature Reviews Molecular Cell Biology contents September 2017 Volume 18 Number 9 pp 529-589

If you are unable to see the message below, click here to view.
Nature Reviews Molecular Cell Biology

nature.com webcasts

Nature Research Custom presents a webcast on: HCS for Predictive Toxicology and in vitro Pathology Using Simple 3D Microtissues

Date: Wednesday, September 6, 2017
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST

Duration: 60 minutes with an opportunity to ask questions during the live broadcast! 

Register for FREE

Sponsored by: 
September 2017 Volume 18 Number 9
Nature Reviews Molecular Cell Biology cover
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights
Also this month
Article series:
DNA damage
 Featured article:
Genes and molecular pathways underpinning ciliopathies
Jeremy F. Reiter & Michel R. Leroux


Recommend to library
Nature Outline: Eardrum Regeneration

A burst eardrum is a common injury. Although ruptures can cause pain and hearing loss, most heal naturally. But for those that don’t, there could soon be an alternative to specialist surgery. Regenerative medicine is helping the eardrum to heal itself. 

Access the Outline free here > 

Produced with support from: 
Translational Research Informatics Center (TRI) 

Kitano Hospital 

Splicing: Phasing alternative exons
p529 | doi:10.1038/nrm.2017.78
Two papers report a new mechanism of controlling alternative splicing through phase separation-mediated formation of higher-order assemblies of splicing factors.

Adult stem cells: Fat cells promote blood regeneration
p530 | doi:10.1038/nrm.2017.79
Following irradiation, adipocytes derived from a specified subset of leptin receptor-positive cells in the bone marrow become a major source of stem cell factor for haematopoietic regeneration.

Stress responses: SIRT1 puts an embargo on mRNA export
p530 | doi:10.1038/nrm.2017.82
Sirtuin 1 deacetylates polyadenylate-binding protein 1 (PABP1), thereby suppressing nuclear export of polyadenylated mRNAs and translation to preserve energy under stress.

Epigenetics: Getting instructions from mum
p531 | doi:10.1038/nrm.2017.81
Patterns of histone H3 Lys27 trimethylation are maternally inherited in both fly and mammalian embryos, and control gene expression during early development.

Cancer biology: A Neat target of p53
p532 | doi:10.1038/nrm.2017.80
The lincRNA Neat1 is a p53 target gene that can suppress the initiation of pancreatic cancer.

Genome organization: A vision of 3D chromatin organization
p532 | doi:10.1038/nrm.2017.88
A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells.


Nature Reviews Molecular Cell Biology
JOBS of the week
Research Scientist I
Gilead Sciences
Senior Research Scientist
MiNA Therapeutics
Postdoctoral researcher in Biochemistry / Molecular Biology
International Clinical Research Center
Director - Clinical Genomic Care
Sidra Medical and Research Centre
Postdoctoral Fellowships in Biomedical Science (Cancer Research)
Columbia University Medical Center
More Science jobs from
Nature Reviews Molecular Cell Biology
International Congress of Cell Biology 2018
Hyderabad, India
More science events from
nature.com webcasts

Nature Research Custom presents: Visualizing divisions and development in 3D

Date: Wednesday, August 30 2017
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST 

The webcast will last for 60 minutes and there will be an opportunity to ask your questions during the live broadcast!

Register for FREE 

Sponsored by:
Genes and molecular pathways underpinning ciliopathies
Jeremy F. Reiter & Michel R. Leroux

p533 | doi:10.1038/nrm.2017.60
Motile and non-motile primary cilia are nearly ubiquitous cellular organelles. Dysfunction of cilia is being found to cause increasing numbers of diseases that are known as ciliopathies. The characterization of ciliopathy-associated proteins and phenotypes is increasing our understanding of how cilia are formed and compartmentalized and how they function to maintain human health.
Abstract | Full Text | PDF | Supplementary information

Understanding nucleosome dynamics and their links to gene expression and DNA replication
William K. M. Lai & B. Franklin Pugh

p548 | doi:10.1038/nrm.2017.47
The presence of nucleosomes and their substructures affects local chromatin structure and function. Thus, nucleosome occupancy, their exact positioning and composition need to be dynamically regulated. Advances in genomic technologies have improved our understanding of nucleosome dynamics in various cellular processes, most notably DNA replication and transcription.
Abstract | Full Text | PDF

Article series: DNA damage
Mechanisms of DNA-protein crosslink repair
Julian Stingele, Roberto Bellelli & Simon J. Boulton

p563 | doi:10.1038/nrm.2017.56
Covalent DNA-protein crosslinks (DPCs) are induced by various compounds, which include widely used anticancer drugs, and are highly cytotoxic. Recent studies have revealed the mechanisms and the regulation of DPC repair pathways and suggest that components of these pathways can serve as targets for anticancer therapies.
Abstract | Full Text | PDF

Classification and function of small open reading frames
Juan-Pablo Couso & Pedro Patraquim

p575 | doi:10.1038/nrm.2017.58
A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution.
Abstract | Full Text | PDF
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature