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donderdag 17 augustus 2017

Nature Reviews Genetics Contents September 2017 Volume 18 Number 9 pp 513-575

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Nature Reviews Genetics

An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. 

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September 2017 Volume 18 Number 9
Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
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Research Highlights

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Article series:
 Featured article:
Exploiting induced and natural epigenetic variation for crop improvement
Nathan M. Springer & Robert J. Schmitz

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The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.

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Epigenetics: Getting instructions from mum
p513 | doi:10.1038/nrg.2017.64

Genome organization: Tracking chromosomal conformation through the cell cycle
p514 | doi:10.1038/nrg.2017.62

Complex disease: From non-coding risk variant to biological mechanism in CAD
p514 | doi:10.1038/nrg.2017.66

Alternative splicing: A thermometer controlling gene expression
p515 | doi:10.1038/nrg.2017.61

Nature Reviews Genetics
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EMBO | EMBL Symposium: Systems Genetics: From Genotypes to Molecular Phenotypes to Complex Traits
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npj Molecular Phenomics is an online-only, open access journal that provides a forum for cutting-edge scientific advances in the emerging field of phenomics, the study of the physical and chemical characteristics of an individual in quantitative terms.

Part of the Nature Partner Journals series, npj Molecular Phenomics is published in partnership with Fudan University. The journal is now open for submissions. 

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Article series: Epigenetics
TET-mediated active DNA demethylation: mechanism, function and beyond
Xiaoji Wu & Yi Zhang
p517 | doi:10.1038/nrg.2017.33
A key mode of regulating DNA methylation is through active demethylation driven by TET-mediated oxidation of 5-methylcytosine (5mC). This Review discusses our latest understanding of the mechanisms and regulation of active DNA demethylation, and the roles of active demethylation (and the oxidized 5mC intermediates) in gene regulation, genome stability, development and disease.
Abstract | Full Text | PDF

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse
p535 | doi:10.1038/nrg.2017.46
Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models.
Abstract | Full Text | PDF

Network propagation: a universal amplifier of genetic associations
Lenore Cowen, Trey Ideker, Benjamin J. Raphael & Roded Sharan
p551 | doi:10.1038/nrg.2017.38
Network propagation is based on the principle that genes underlying similar phenotypes are more likely to interact with each other. It is proving to be a powerful approach for extracting biological information from molecular networks that is relevant to human disease.
Abstract | Full Text | PDF

Article series: Epigenetics
Exploiting induced and natural epigenetic variation for crop improvement
Nathan M. Springer & Robert J. Schmitz
p563 | doi:10.1038/nrg.2017.45
To unlock the potential of epigenetic variation for crop improvement, it will be crucial to understand how epigenetic variation is established and how it is stably inherited across generations. Springer and Schmitz review these challenges, the different sources of epigenetic variation in plants, and how epigenome profiling and engineering could help to improve crops.
Abstract | Full Text | PDF

Immune Repertoire Profiling at Single Cell Resolution 

The Chromium™ Single Cell V(D)J Solution is a comprehensive, scalable tool for profiling full-length V(D)J sequences on a cell-by-cell basis, obtaining fantastic insight into the adaptive immune system. 

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