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woensdag 23 augustus 2017

Nature Immunology Contents: September 2017 Volume 18 pp 953 - 1057

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Nature Immunology

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News and Views


Myelopoiesis embraces its inner weakness   pp953 - 954
Motti Gerlic and Ben A Croker
The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

See also: Article by Kanayama et al.

Fat T cells go to the joint   pp955 - 956
George C Tsokos
Poor glycolysis and increased fatty-acid synthesis feed the locomotion machinery in T cells from people with rheumatoid arthritis and allow these cells to enter the synovium and propagate joint inflammation and destruction.

See also: Article by Shen et al.

MLL4 keeps Foxp3 in the loop   pp957 - 958
Dong-Mei Zhao and Hai-Hui Xue
The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.

See also: Article by Placek et al.

NK cells join the plasticity party   pp959 - 960
Jonathan S Silver and Alison A Humbles
The cytokine TGF-β allows tumors to evade the immune system by converting conventional natural killer cells into type 1 innate lymphoid cells devoid of cytotoxic function.

See also: Article by Cortez et al. | Article by Gao et al.

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Research Highlights


Pathways in opposition | The eyes have it | Rodent hepatitis C model | Dopamine in germinal centers | Losing IFN | Amplifying senescence



Gene regulation in the immune system by long noncoding RNAs   pp962 - 972
Y Grace Chen, Ansuman T Satpathy and Howard Y Chang
Long non-coding RNAs (lncRNAs) are being increasingly appreciated as important regulators of gene expression. Chang and colleagues review the roles identified for lncRNAs in the immune system and discuss models for how lncRNAs mediate their effects.



Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin   pp973 - 984
Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue et al.
The size of immune-cell populations needs to be tightly regulated. Shinohara and colleagues demonstrate that intracellular and secreted osteopontin control the contraction and expansion of myeloid and lymphoid populations differently under infectious and autoimmune conditions.

See also: News and Views by Gerlic & Croker

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming   pp985 - 994
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav et al.
How glutamine metabolism orchestrates macrophage activation is unclear. Ho and colleagues show glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming.

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling   pp995 - 1003
Victor S Cortez, Tyler K Ulland, Luisa Cervantes-Barragan, Jennifer K Bando, Michelle L Robinette et al.
Colonna and colleagues generate mice in which both type 1 innate lymphoid cells and natural killer cells selectively lack SMAD4, which promotes canonical signaling of all cytokines of the TGF-β family. Unexpectedly, SMAD4 deficiency does not visibly affect the differentiation of type 1 innate lymphoid cells but instead alters the phenotype of conventional natural killer cells.

See also: News and Views by Silver & Humbles | Article by Gao et al.

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells   pp1004 - 1015
Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young et al.
How tumors evade control by natural killer cells is ill defined. Smyth and colleagues show that natural killer cells in the tumor microenvironment can convert into type I innate lymphoid cells and intermediate type I innate lymphoid cells that favor tumor growth and metastasis.

See also: News and Views by Silver & Humbles | Article by Cortez et al.

Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus   pp1016 - 1024
Sun Jung Kim, Sebastian Schätzle, S Sohail Ahmed, Wolfgang Haap, Su Hwa Jang et al.
Cathepsin S is responsible for cleaving the invariant chain Ii for the presentation of peptides by major histocompatibility complex class II on DCs. Diamond and colleagues show that the transcription factor Blimp-1 negatively regulates expression of cathepsin S and influences selection of the TFH cell repertoire and autoantibody-producing B cells.

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells   pp1025 - 1034
Yi Shen, Zhenke Wen, Yinyin Li, Eric L Matteson, Jison Hong et al.
Previous studies have defined a state of metabolic reprogramming in rheumatoid arthritis (RA) T cells. Here Weyand and colleagues show that the rewiring of cellular metabolism renders RA T cells tissue invasive, directly promoting disease-inducing effector functions.

See also: News and Views by Tsokos

MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping   pp1035 - 1045
Katarzyna Placek, Gangqing Hu, Kairong Cui, Dunfang Zhang, Yi Ding et al.
Zhao and colleagues show that the histone lysine methyltransferase MLL4 primes the Foxp3 locus for transcriptional activation in thymus-derived and inducible regulatory T cells.

See also: News and Views by Zhao & Xue

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Translation is actively regulated during the differentiation of CD8+ effector T cells   pp1046 - 1057
Koichi Araki, Masahiro Morita, Annelise G Bederman, Bogumila T Konieczny, Haydn T Kissick et al.
T cells undergo myriad changes after antigenic activation. Araki and colleagues show that CD8+ T cells exert dynamic control of mRNA translation during differentiation into effector and memory cells.

npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions.

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