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British Journal of Cancer

Volume 117, Issue 5 (597-756)
Published online 22 August 2017

In this issue
Clinical Studies
Translational Therapeutics
Molecular Diagnostics
Genetics & Genomics

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New web focus from BJC: Tumour microenvironment

The tumour microenvironment (TME) comprises the spectrum of non-neoplastic cells (for example, fibroblasts and immune/inflammatory cells), vessels and associated matrix contained within a cancer. Far from being just a passive scaffold, it is now well established that the two-way interaction between these stromal components and the tumour cells themselves plays an active, and in many cases crucial, role in modulating tumour growth (through both stimulatory and inhibitory actions). 

David Wynford-Thomas has put together a special collection of papers on TME >>>

Clinical Studies


Knowledge or noise? Making sense of General Practitioners’ and Consultant use of 2-week-wait referrals for suspected cancer

Conan Donnelly, Nigel Hart, Alan David McCrorie, Lesley Anderson, Michael Donnelly, Peter Murchie and Anna Gavin

Br J Cancer 2017 117: 597-603; advance online publication, July 27, 2017; 10.1038/bjc.2017.213

Abstract | Full Text

Long-term outcomes of patients with 10 or more colorectal liver metastases

M A Allard, R Adam, F Giuliante, R Lapointe, C Hubert, J N M Ijzermans, D F Mirza, D Elias, C Laurent, T Gruenberger, G Poston, C Letoublon, H Isoniemi, V Lucidi, I Popescu and J Figueras

Br J Cancer 2017 117: 604-611; advance online publication, July 20, 2017; 10.1038/bjc.2017.218

Abstract | Full Text

Hamburg-Glasgow classification: preoperative staging by combination of disseminated tumour load and systemic inflammation in oesophageal carcinoma

Matthias Reeh, Tarik Ghadban, Faik G Uzunoglu, Michael F Nentwich, Maximilian Bockhorn, Klaus Pantel, Jakob R Izbicki and Yogesh K Vashist

Br J Cancer 2017 117: 612-618; advance online publication, July 13, 2017; 10.1038/bjc.2017.219

Abstract | Full Text

The cost-effectiveness of screening for ovarian cancer: results from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Usha Menon, Alistair J McGuire, Maria Raikou, Andy Ryan, Susan K Davies, Matthew Burnell, Aleksandra Gentry-Maharaj, Jatinderpal K Kalsi, Naveena Singh, Nazar N Amso, Derek Cruickshank, Stephen Dobbs, Keith Godfrey, Jonathan Herod, Simon Leeson, Tim Mould, John Murdoch, David Oram, Ian Scott, Mourad W Seif, Karin Williamson, Robert Woolas, Lesley Fallowfield, Stuart Campbell, Steven J Skates, Mahesh Parmar and Ian J Jacobs

Br J Cancer 2017 117: 619-627; advance online publication, July 25, 2017; 10.1038/bjc.2017.222

Abstract | Full Text

Translational Therapeutics


Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models

Cristina Belgiovine, Ezia Bello, Manuela Liguori, Ilaria Craparotta, Laura Mannarino, Lara Paracchini, Luca Beltrame, Sergio Marchini, Carlos M Galmarini, Alberto Mantovani, Roberta Frapolli, Paola Allavena and Maurizio D'Incalci

Br J Cancer 2017 117: 628-638; advance online publication, July 6, 2017; 10.1038/bjc.2017.205

Abstract | Full Text

HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer

Michelle J Veite-Schmahl, William C Joesten and Michael A Kennedy

Br J Cancer 2017 117: 639-647; advance online publication, July 11, 2017; 10.1038/bjc.2017.216

Abstract | Full Text

Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients

Roopma Wadhwa, Xuemei Wang, Veerabhadran Baladandayuthapani, Bin Liu, Hironori Shiozaki, Yusuke Shimodaira, Quan Lin, Elena Elimova, Wayne L Hofstetter, Stephen G Swisher, David C Rice, Dipen M Maru, Neda Kalhor, Manoop S Bhutani, Brian Weston, Jeffrey H Lee, Heath D Skinner, Ailing W Scott, Dilsa Mizrak Kaya, Kazuto Harada, Donald Berry, Shumei Song and Jaffer A Ajani

Br J Cancer 2017 117: 648-655; advance online publication, July 20, 2017; 10.1038/bjc.2017.225

Abstract | Full Text

TCTP as a therapeutic target in melanoma treatment

M Boia-Ferreira, A B Basílio, A E Hamasaki, F H Matsubara, M H Appel, C R V Da Costa, R Amson, A Telerman, O M Chaim, S S Veiga and A Senff-Ribeiro

Br J Cancer 2017 117: 656-665; advance online publication, July 27, 2017; 10.1038/bjc.2017.230

Abstract | Full Text

Molecular Diagnostics


A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours

Matthew R Russell, Ciaren Graham, Alfonsina D'Amato, Aleksandra Gentry-Maharaj, Andy Ryan, Jatinderpal K Kalsi, Carol Ainley, Anthony D Whetton, Usha Menon, Ian Jacobs and Robert L J Graham

Br J Cancer 2017 117: 666-674; advance online publication, June 29, 2017; 10.1038/bjc.2017.199

Abstract | Full Text

RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer

Jing Wu, Xu-Jie Zhou, Xi Sun, Tian-Song Xia, Xiao-Xia Li, Liang Shi, Lei Zhu, Wen-Bin Zhou, Ji-Fu Wei and Qiang Ding

Br J Cancer 2017 117: 675-684; advance online publication, July 6, 2017; 10.1038/bjc.2017.204

Abstract | Full Text

The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone

Yuhu Dai, Dong Ren, Qing Yang, Yanmei Cui, Wei Guo, Yingrong Lai, Hong Du, Chuyong Lin, Jun Li, Libing Song and Xinsheng Peng

Br J Cancer 2017 117: 685-694; advance online publication, July 11, 2017; 10.1038/bjc.2017.212

Abstract | Full Text

Platelet releasate promotes breast cancer growth and angiogenesis via VEGF–integrin cooperative signalling

Lei Jiang, Yun Luan, Xinyan Miao, Chao Sun, Kailin Li, Zhangsen Huang, Dawei Xu, Mingxiang Zhang, Feng Kong and Nailin Li

Br J Cancer 2017 117: 695-703; advance online publication, July 11, 2017; 10.1038/bjc.2017.214

Abstract | Full Text

Correlation between circulating mutant DNA and metabolic tumour burden in advanced non-small cell lung cancer patients

Anne Winther-Larsen, Christina Demuth, Joan Fledelius, Anne Tranberg Madsen, Karin Hjorthaug, Peter Meldgaard and Boe Sandahl Sorensen

Br J Cancer 2017 117: 704-709; advance online publication, July 6, 2017; 10.1038/bjc.2017.215

Abstract | Full Text

Genetics & Genomics


A comparative study of germline BRCA1 and BRCA2 mutation screening methods in use in 20 European clinical diagnostic laboratories

Gillian Ellison, Andrew Wallace, Alexander Kohlmann and Simon Patton

Br J Cancer 2017 117: 710-716; advance online publication, July 27, 2017; 10.1038/bjc.2017.223

Abstract | Full Text

Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma

Hiroaki Itamochi, Tetsuro Oishi, Nao Oumi, Satoshi Takeuchi, Kosuke Yoshihara, Mikio Mikami, Nobuo Yaegashi, Yasuhisa Terao, Kazuhiro Takehara, Kimio Ushijima, Hidemichi Watari, Daisuke Aoki, Tadashi Kimura, Toshiaki Nakamura, Yoshihito Yokoyama, Junzo Kigawa and Toru Sugiyama

Br J Cancer 2017 117: 717-724; advance online publication, July 20, 2017; 10.1038/bjc.2017.228

Abstract | Full Text

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma

Sarah Schumacher, Christoph Bartenhagen, Martin Hoffmann, Daniel Will, Johannes C Fischer, Stephan E Baldus, Christian Vay, Georg Fluegen, Levent Dizdar, Daniel Vallböhmer, Christoph A Klein, Wolfram T Knoefel, Nikolas H Stoecklein and Birte Möhlendick

Br J Cancer 2017 117: 725-733; advance online publication, July 20, 2017; 10.1038/bjc.2017.233

Abstract | Full Text



Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, The PRACTICAL consortium, Douglas Easton, Rosalind A Eeles and Kenneth Muir

Br J Cancer 2017 117: 734-743; advance online publication, August 1, 2017; 10.1038/bjc.2017.231

Abstract | Full Text

Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer

Marliese Alexander, Rory Wolfe, David Ball, Matthew Conron, Robert G Stirling, Benjamin Solomon, Michael MacManus, Ann Officer, Sameer Karnam, Kate Burbury and Sue M Evans

Br J Cancer 2017 117: 744-751; advance online publication, July 20, 2017; 10.1038/bjc.2017.232

Abstract | Full Text

Leukocyte telomere length and renal cell carcinoma survival in two studies

Catherine L Callahan, Kendra Schwartz, Julie J Ruterbusch, Brian Shuch, Barry I Graubard, Qing Lan, Richard Cawthon, Andrea A Baccarelli, Wong-Ho Chow, Nathaniel Rothman, Jonathan N Hofmann and Mark P Purdue

Br J Cancer 2017 117: 752-755; advance online publication, July 25, 2017; 10.1038/bjc.2017.237

Abstract | Full Text



Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

A Kenneth MacLeod, Lourdes Acosta-Jimenez, Philip J Coates, Michael McMahon, Frank A Carey, Tadashi Honda, John D Hayes, Colin J Henderson and C Roland Wolf

Br J Cancer 2017 117: e1; advance online publication, March 21, 2017; 10.1038/bjc.2017.80

Full Text

The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer

C B Lajer, E Garnæs, L Friis-Hansen, B Norrild, M H Therkildsen, M Glud, M Rossing, H Lajer, D Svane, L Skotte, L Specht, C Buchwald and F C Nielsen

Br J Cancer 2017 117: e2; advance online publication, July 13, 2017; 10.1038/bjc.2017.203

Full Text

Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations

S Hu, R H J Mathijssen, P de Bruijn, S D Baker and A Sparreboom

Br J Cancer 2017 117: e3; advance online publication, July 13, 2017; 10.1038/bjc.2017.217

Full Text

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