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woensdag 26 juli 2017

Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 14 Issue 8

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Nature Reviews Gastroenterology & Hepatology

August 2017 Volume 14 Number 8
Nature Reviews Gastroenterology & Hepatology cover
2016 2-year Impact Factor 13.678 Journal Metrics 2-year Median 8
In this issue
Research Highlights
News and Views
Consensus Statement

Also this month
Article series:
Eliminating viral hepatitis
 Featured article:
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
Gyongyi Szabo & Fatemeh Momen-Heravi

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Article series: Eliminating viral hepatitis
Eliminating viral hepatitis — momentum must keep building
Published online: 26 July 2017
p443 | doi:10.1038/nrgastro.2017.107

Full Text | PDF

Article series: Eliminating viral hepatitis
Comment: Many European countries 'flying blind' in their efforts to eliminate viral hepatitis
Jeffrey V. Lazarus et al.
Published online: 26 July 2017
p445 | doi:10.1038/nrgastro.2017.98

More people die from viral hepatitis than from HIV, yet the public health response is lacking. The ACHIEVE Coalition urges governments in Europe and elsewhere to improve hepatitis B and hepatitis C monitoring so that a reliable evidence base will be available to guide the drive towards disease elimination.
Full Text | PDF

Article series: Eliminating viral hepatitis
Comment: HCV elimination — lessons learned from a small Eurasian country, Georgia
Muazzam Nasrullah, David Sergeenko, Amiran Gamkrelidze & Francisco Averhoff
Published online: 26 July 2017
p447 | doi:10.1038/nrgastro.2017.100

In April 2015, in partnership with the US Centers for Disease Control and Prevention and Gilead Sciences, the country of Georgia launched the world's first national HCV elimination programme, aiming to reduce HCV prevalence by 90% by 2020. After 2 years of progress, how can the Georgia experience inform global approaches to eliminating HCV?
Full Text | PDF | Supplementary information


Neurogastroenterology: Tasting the gut — enterochromaffin cells are chemosensitive and modulate sensory neurons
Published online: 05 July 2017
p449 | doi:10.1038/nrgastro.2017.91


Stomach: A chief role for Lgr5+ cells
Published online: 21 June 2017
p450 | doi:10.1038/nrgastro.2017.87


Viral hepatitis: Charting HCV genotype 2/1 recombinant strains
Published online: 28 June 2017
p450 | doi:10.1038/nrgastro.2017.89


NAFLD: Thermoneutral housing of mice improves modelling of NAFLD
Published online: 28 June 2017
p451 | doi:10.1038/nrgastro.2017.90



Rotavirus: Inflammasome modulates rotavirus infection | NAFLD: Increased familial risk of fibrosis in NAFLD | Rectal cancer: No benefit for local excision over rectal excision

Nature Reviews Gastroenterology & Hepatology
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China Novartis Institutes for BioMedical Research (NIBR), Shanghai
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Article series: Eliminating viral hepatitis
Direct-acting antivirals for paediatric HCV: we got there
Etienne M. Sokal
Published online: 26 July 2017
p452 | doi:10.1038/nrgastro.2017.92
In a new report, adolescents with genotype 2 or 3 HCV infection who were given sofosbuvir and ribavirin showed a near 100% sustained virologic response. This study is the beginning of a new wave of treatments for paediatric HCV infection, forming part of a global strategy to eradicate viral hepatitis.
Full Text | PDF

Neurogastroenterology: The dynamic cycle of life in the enteric nervous system
Meenakshi Rao & Michael D. Gershon
Published online: 28 June 2017
p453 | doi:10.1038/nrgastro.2017.85
The stability of the neuronal circuits and cells of the enteric nervous system can no longer be taken for granted; new evidence suggests astounding rates of apoptosis and neurogenesis.
Full Text | PDF

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
Gyongyi Szabo & Fatemeh Momen-Heravi
Published online: 21 June 2017
p455 | doi:10.1038/nrgastro.2017.71
Extracellular vesicles have emerged as having key roles in liver disease. In this Review, Szabo and Momen-Heravi discuss the functions of extracellular vesicles in liver disease pathogenesis and progression, and explore their potential use as biomarkers, therapeutic targets and tools for therapy delivery.
Abstract | Full Text | PDF

How to stomach an epigenetic insult: the gastric cancer epigenome
Nisha Padmanabhan, Toshikazu Ushijima & Patrick Tan
Published online: 17 May 2017
p467 | doi:10.1038/nrgastro.2017.53
Gastric cancer is a deadly malignancy and accumulating evidence suggests that epigenetic abnormalities promote carcinogenesis. Here, the authors summarize the gastric cancer epigenome, highlighting key advances from studies of DNA methylation and histone modifications, and how these findings might lead to therapeutic opportunities.
Abstract | Full Text | PDF

Management of refractory eosinophilic oesophagitis
Evan S. Dellon
Published online: 24 May 2017
p479 | doi:10.1038/nrgastro.2017.56
The clinical management of refractory eosinophilic oesophagitis (EoE) is challenging, owing to the limited data available to guide decision-making. In this Review, Dellon discusses the clinical definition of refractory EoE, examines the causes and predictors of non-response, and highlights both current and emerging treatment modalities for non-responders.
Abstract | Full Text | PDF

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Glenn R. Gibson et al.
Published online: 14 June 2017
p491 | doi:10.1038/nrgastro.2017.75

With the continued interest in the role of the gut microbiota in health, attention has now turned to how to harness the microbiota for the benefit of the host. This Consensus Statement outlines the definition and scope of the term 'prebiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in December 2016.

Abstract | Full Text | PDF
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