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maandag 26 juni 2017

Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 14 Issue 7

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Nature Reviews Gastroenterology & Hepatology

Call for nominations: 2017 John Maddox Prize for Standing up for Science.

Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000.

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July 2017 Volume 14 Number 7Advertisement
Nature Reviews Gastroenterology & Hepatology cover
2016 2-year Impact Factor 13.678 Journal Metrics 2-year Median 8
In this issue
Research Highlights
News and Views

Also this month
Article series:
Cell & developmental biology in the digestive system
 Featured article:
Mechanisms of hepatic stellate cell activation
Takuma Tsuchida & Scott L. Friedman


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Comment: Helicobacter pylori infection and antibiotic resistance: a WHO high priority?
Bich N. Dang & David Y. Graham
Published online: 03 May 2017
p383 | doi:10.1038/nrgastro.2017.57

The WHO listed Helicobacter pylori among 16 antibiotic-resistant bacteria that pose the greatest threat to human health. Given the alarmingly high H. pylori antibiotic resistance rates, antibiotic stewardship programmes need to be developed and implemented. Future research should explore provider and systems-level barriers to H. pylori antibiotic susceptibility testing.

Full Text | PDF


Gut microbiota: Intestinal fungi fuel the inflammatory fire in alcoholic liver disease
Published online: 07 June 2017
p385 | doi:10.1038/nrgastro.2017.78


IBS: Mindful of probiotics for psychiatric comorbidities in IBS
Published online: 24 May 2017
p386 | doi:10.1038/nrgastro.2017.70


Neurogastroenterology: Cell lineage relationships dictate ENS organization
Published online: 07 June 2017
p386 | doi:10.1038/nrgastro.2017.77


Gut microbiota: Trust your gut — metformin and diabetes
Published online: 31 May 2017
p387 | doi:10.1038/nrgastro.2017.73


IBD: Tofacitinib effective in ulcerative colitis
Published online: 17 May 2017
p388 | doi:10.1038/nrgastro.2017.66


NAFLD: A gut microbiome signature for advanced fibrosis diagnosis in NAFLD
Published online: 17 May 2017
p388 | doi:10.1038/nrgastro.2017.67


Infection: Unlocking the 'crypto' drug cabinet
Published online: 14 June 2017
p388 | doi:10.1038/nrgastro.2017.81



IBD: Phase II trial success for anti-MADCAM1 antibody | Therapy: Bacteriophages important for FMT efficacy | Primary sclerosing cholangitis: Ursodeoxycholic acid derivative: safe and effective

Nature Reviews Gastroenterology & Hepatology
JOBS of the week
Gastroenterology Position at St. Vincent Healthcare
St. Vincent Healthcare
General Gastroenterologist with ERCP
St. Joseph Healthcare
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Tulane University
Chair, Division of Gastroenterology
Einstein Healthcare Network (EHN)
Gastroenterologist – Loyola University Medical Center
Loyola University Chicago
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Surgery: Metabolic surgery: the cutting edge of diabetes care
Francesco Rubino & Spyros Panagiotopoulos
Published online: 21 April 2017
p389 | doi:10.1038/nrgastro.2017.45
International guidelines recognize surgery as a standard treatment option for type 2 diabetes mellitus, including in mildly obese individuals who fail to respond to conventional therapies. A new report from the STAMPEDE trial now provides further evidence and emphasizes the need for health care regulators to introduce appropriate reimbursement policies for metabolic surgery.
Full Text | PDF

Genetics: Novel causative genes for polycystic liver disease
Maria J. Perugorria & Jesus M. Banales
Published online: 31 May 2017
p391 | doi:10.1038/nrgastro.2017.69
A new study identifies heterozygous loss-of-function mutations in three additional genes (ALG8, SEC61B and PKHD1) as causative for the development and progression of isolated polycystic liver diseases. Mutations in these genes, together with previously described mutations in other genes (PRKCSH, SEC63, LRP5 and GANAB), might now explain [sim]50% of PLD cases.
Full Text | PDF

Gut microbiota: Inulin regulates endothelial function: a prebiotic smoking gun?
Francesca Fava & Kieran M. Tuohy
Published online: 31 May 2017
p392 | doi:10.1038/nrgastro.2017.68
A new study shows that the prebiotic inulin improves vascular function in an animal model of cardiovascular disease. A key mechanism for how dietary gut microbiota modulation regulates host physiology through the activities of host-microbiota co-metabolic signalling via bile acids and glucagon-like peptide 1 is also explained.
Full Text | PDF

Paediatrics: Are human milk oligosaccharides the magic bullet for necrotizing enterocolitis?
Michael S. Caplan
Published online: 17 May 2017
p394 | doi:10.1038/nrgastro.2017.65
There have been no major improvements in the prevention or treatment of necrotizing enterocolitis (NEC) over the past several decades, and therefore a 'magic bullet' is urgently needed. However, new data demonstrate that disialyllacto-N-tetraose levels in breast milk can predict the risk of NEC, and these findings might provide a strategy for successful intervention.
Full Text | PDF

Article series: Cell & developmental biology in the digestive system
Mechanisms of hepatic stellate cell activation
Takuma Tsuchida & Scott L. Friedman
Published online: 10 May 2017
p397 | doi:10.1038/nrgastro.2017.38
Activation of hepatic stellate cells (HSCs) in liver injury is the primary driver of hepatic fibrosis. In this Review, Tsuchida and Friedman detail the varied intracellular and extracellular signalling pathways leading to HSC activation, as well as the role of HSCs in liver fibrosis resolution and as therapeutic targets.
Abstract | Full Text | PDF

Non-conventional features of peripheral serotonin signalling — the gut and beyond
Stephanie N. Spohn & Gary M. Mawe
Published online: 10 May 2017
p412 | doi:10.1038/nrgastro.2017.51
Serotonin is a key intercellular signalling molecule with well-known functions in the gastrointestinal tract, particularly for motility. This Review explores the non-conventional roles of gut-derived serotonin in the gut and other peripheral tissues, including during gastrointestinal inflammation, haematopoiesis, metabolic homeostasis and bone remodelling.
Abstract | Full Text | PDF

A guide to multimodal endoscopy imaging for gastrointestinal malignancy — an early indicator
Arthur Hoffman, Henrik Manner, Johannes W. Rey & Ralf Kiesslich
Published online: 14 June 2017
p421 | doi:10.1038/nrgastro.2017.46
Imaging and endoscopy remains key to the diagnosis of gastrointestinal malignancies, especially for early disease detection. Here, the authors describe multimodal imaging techniques and how they can be applied along the gastrointestinal tract, in particular for the identification of pre-malignant lesions in the oesophagus, stomach and colon.
Abstract | Full Text | PDF

Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link
Uday C. Ghoshal & Kok-Ann Gwee
Published online: 17 May 2017
p435 | doi:10.1038/nrgastro.2017.37
Acute gastroenteritis precipitates post-infectious IBS in 10-30% of patients. In this Perspectives, Ghoshal and Gwee discuss evidence of overlap between post-infectious IBS, tropical sprue (which can also develop after acute gastroenteritis) and small intestinal bowel overgrowth, and argue that greater understanding of the links between these conditions will improve understanding of IBS pathogenesis.
Abstract | Full Text | PDF

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