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donderdag 27 april 2017

The Lancet: [Series] Management of elderly patients with locoregionally confined head and neck cancer

[Series] Management of elderly patients with locoregionally confined head and neck cancer
Head and neck cancer in elderly patients represents a major health burden because its management provides unique and complex challenges for multidisciplinary teams, such as reduced treatment tolerance, multiple comorbidities, and altered pharmacokinetics and pharmacodynamics. Despite the prominent challenges involved, high-level evidence for the management of this group of patients is scarce. Substantial advances in treatment, such as robotic surgery, dynamic intensity-modulated radiation therapy, immunotherapy, and de-escalation trials, might allow for improved treatment tolerance in this patient population.
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[Articles] Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study
Colonoscopy surveillance benefits most patients with intermediate-risk adenomas. However, some patients are already at low risk after baseline colonoscopy and the value of surveillance for them is unclear.
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[Comment] Can post-polypectomy surveillance be less intensive?
Strong evidence from randomised trials in support of screening led to a consensus in 1997, which resulted in the publication of US guidelines recommending colorectal cancer screening.1 This recommendation resulted in an exponential proliferation of screening programmes with the subsequent identification of large numbers of patients with adenomatous polyps—the most common neoplastic outcome of screening—the removal of which reduces colorectal cancer incidence and mortality.2 The consensus was that, following polypectomy, patients should be placed under surveillance because they were considered to be at increased risk for subsequent adenomas and colorectal cancer.
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[News] Treatment options for early-stage Hodgkin's lymphoma
Reduced-intensity combined-modality treatment is a largely beneficial strategy for early-stage Hodgkin's lymphoma, according to a long-term follow-up of four German Hodgkin Study Group trials, done by Stephanie Sasse (University Hospital of Cologne, Cologne, Germany) and colleagues.
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[News] Pregnancy complications in survivors of childhood cancer
Female survivors of childhood cancer who received abdominal radiotherapy have an increased risk of hypertension, gestational diabetes, and anaemia during pregnancy compared with survivors who did not receive radiotherapy, according to new research.
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