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vrijdag 21 april 2017

Nature Reviews Rheumatology - Table of Contents alert Volume 13 Issue 5

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Nature Reviews Rheumatology

May 2017 Volume 13 Number 5
Nature Reviews Rheumatology cover
2015 2-year Impact Factor 10.531 Journal Metrics 2-year Median 7
In this issue
Research Highlights
News and Views
Focus on: Immunometabolism

Also this month
 Featured article:
Immunometabolism in early and late stages of rheumatoid arthritis
Cornelia M. Weyand & Jörg J. Goronzy

Recommend to library
Presented by: Ospedale San Raffaele | Nature

The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration.

November 16-18, 2017 | Milan, Italy

September 17-19, 2017 | Seattle, WA, USA

Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology


Osteoarthritis: Metabolic syndrome and risk of knee OA
Published online: 21 April 2017
p257 | doi:10.1038/nrrheum.2017.41


Immunometabolism: IL-37 fights inflammation-induced fatigue
Published online: 02 March 2017
p258 | doi:10.1038/nrrheum.2017.28


Systemic sclerosis: Knocking out FLI1 to clear the AIRE
Published online: 16 March 2017
p259 | doi:10.1038/nrrheum.2017.39


Systemic lupus erythematosus: Defective CD11b raises IFN levels in SLE
Published online: 23 March 2017
p259 | doi:10.1038/nrrheum.2017.44


Lupus nephritis: Novel role for BAFF in tertiary lymphoid neogenesis
Published online: 16 March 2017
p260 | doi:10.1038/nrrheum.2017.40


Experimental arthritis: IL-38 promotes anti-inflammatory effects
Published online: 06 April 2017
p260 | doi:10.1038/nrrheum.2017.55



Infection: Therapeutics and risk of infection in pregnancy | Osteoarthritis: A new tool for measuring synovial inflammation | Risk Factors: Generational differences in arthritis prevalence | Therapy: Monitoring risk of anterior uveitis in AS

Nature Reviews Rheumatology
JOBS of the week
Rheumatology / Immunology Faculty position
Columbia University Medical Center
Chair, Department of Gastroenterology and Hepatology
Cleveland Clinic
Tenure Track Assistant / Associate Professor Positions
University of Michigan
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Nature Reviews Rheumatology
5th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD)
Gold Coast, Australia
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Bone: Osteoblasts and global energy metabolism - beyond osteocalcin
Hong Zhou & Markus J. Seibel
Published online: 09 March 2017
p261 | doi:10.1038/nrrheum.2017.35
There is mounting evidence that osteoblasts are involved in the regulation of global energy metabolism. Although osteocalcin signalling remains important, the complexity of systemic energy storage and expenditure makes it likely that hitherto unknown factors are also involved in osteoblast-mediated regulation of metabolism.
Full Text | PDF

Rheumatoid arthritis: The ins and outs of platelets in RA
Isabel Andia
Published online: 06 April 2017
p262 | doi:10.1038/nrrheum.2017.52
New insights into the ability of platelets to modify lymphocyte biology suggest a potential anti-inflammatory role for platelet therapy in rheumatoid arthritis. The success of this therapy will depend on researchers being able to define the best formulation to manipulate the crosstalk between inflammatory, vascular and synovial cells.
Full Text | PDF

Spondyloarthropathies: How should axial spondyloarthritis be diagnosed?
Jürgen Braun & Uta Kiltz
Published online: 16 March 2017
p264 | doi:10.1038/nrrheum.2017.38
Results from a cohort study are challenging the diagnostic algorithm proposed by the Assessment of Spondyloarthritis International Society by showing that rheumatologists are not always confirming a diagnosis of axial spondyloarthritis in patients with multiple features of spondyloarthritis. How will these results affect the future development of classification criteria?
Full Text | PDF

  Focus on: Immunometabolism
Metabolic regulation of inflammation
Timo Gaber, Cindy Strehl & Frank Buttgereit
Published online: 23 March 2017
p267 | doi:10.1038/nrrheum.2017.37
The need for energy permeates every aspect of the life of immune cells, being especially important during periods of transition and differentiation such as during inflammation. In this Review, the authors provide an overview of the processes and pathways involved in immunometabolism.
Abstract | Full Text | PDF

Immunometabolism in systemic lupus erythematosus
Laurence Morel
Published online: 31 March 2017
p280 | doi:10.1038/nrrheum.2017.43
Metabolic abnormalities have been reported in immune cells in lupus, notably in T cells from patients with systemic lupus erythematosus (SLE) but also in other immune cell types. This Review discusses recent clinical and experimental evidence for cell-specific metabolic dysfunction in SLE, and the potential therapeutic benefit of targeting these processes.
Abstract | Full Text | PDF

Immunometabolism in early and late stages of rheumatoid arthritis
Cornelia M. Weyand & Jörg J. Goronzy
Published online: 31 March 2017
p291 | doi:10.1038/nrrheum.2017.49
Metabolic reprogramming of immune cells in disease has functional consequences and presents potential therapeutic opportunities. In this Review, Weyand & Goronzy examine the role of immunometabolism in rheumatoid arthritis, looking particularly at the different metabolic pathways used in early and late stages of disease.
Abstract | Full Text | PDF

The role of metabolism in the pathogenesis of osteoarthritis
Ali Mobasheri, Margaret P. Rayman, Oreste Gualillo, Jérémie Sellam, Peter van der Kraan & Ursula Fearon
Published online: 06 April 2017
p302 | doi:10.1038/nrrheum.2017.50
Metabolic reprogramming of immune cells and somatic cells alike has a role in perpetuating disease in the joints. In this Review, the authors examine metabolic alterations that occur in the main cells of the joint tissues during osteoarthritis.
Abstract | Full Text | PDF

Fine tuning of immunometabolism for the treatment of rheumatic diseases
Jillian P. Rhoads, Amy S. Major & Jeffrey C. Rathmell
Published online: 06 April 2017
p313 | doi:10.1038/nrrheum.2017.54
The pathways by which cells modulate metabolism to attain optimal effector responses present numerous potential therapeutic targets in the context of rheumatic diseases. This article explores the ways in which selective manipulation of metabolic pathways might influence immune cell populations and provide protection from inflammation and disease.
Abstract | Full Text | PDF

Corrigendum: The emerging safety profile of JAK inhibitors in rheumatic disease
Kevin L. Winthrop
Published online: 31 March 2017
p320 | doi:10.1038/nrrheum.2017.51

Full Text | PDF
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Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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