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dinsdag 25 april 2017

Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 14 Issue 5

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Nature Reviews Gastroenterology & Hepatology

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Nature Reviews Gastroenterology & Hepatology cover
2015 2-year Impact Factor 14.435 Journal Metrics 2-year Median 8
In this issue
Research Highlights
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Article series:
Techniques, technology & analysis
 Featured article:
Current and emerging therapeutic targets for IBD
Markus F. Neurath

Nature Outlook: Inflammatory Bowel Disease (IBD)

For certain infections, faecal transplants have resulted in remarkable recoveries. Will the same ever be true for people with IBD? It's a condition on the rise in Asia, but why? Follow those trying to find out, and learn how our environments influence IBD in this Outlook. 

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Stem cells: A case of metabolic identity in the intestinal crypt
Published online: 30 March 2017
p259 | doi:10.1038/nrgastro.2017.41


Liver: PET for bile transport kinetics
Published online: 15 March 2017
p260 | doi:10.1038/nrgastro.2017.36


Gut microbiota: NLRP12 regulates gut microbiota to suppress intestinal inflammation
Published online: 30 March 2017
p260 | doi:10.1038/nrgastro.2017.43


IBD: Oncostatin M promotes inflammation in IBD
Published online: 12 April 2017
p261 | doi:10.1038/nrgastro.2017.47



IBD: Risk stratification in children with Crohn's disease | Liver: BMI, diabetes and liver disease risk in adolescents | Diarrhoea: Low-cost rotavirus vaccine shows efficacy in Niger

Nature Reviews Gastroenterology & Hepatology
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Gut microbiota: Neonatal gut microbiota induces lung immunity against pneumonia
Sabrina Tamburini & Jose C. Clemente
Published online: 22 March 2017
p263 | doi:10.1038/nrgastro.2017.34
Disruption of the microbiota during early life can have important consequences for infant health outcomes; in particular, antibiotic usage is linked to an increased risk of pneumonia. A new study has identified cellular and molecular mediators involved in the crosstalk between early-life gut bacterial colonization and development of lung immunity against pneumonia in newborn mice.
Full Text | PDF
Hepatitis: MicroRNA antagonists: promising antiviral agents against HCV and other viruses?
Jean-Michel Pawlotsky
Published online: 15 March 2017
p264 | doi:10.1038/nrgastro.2017.28
A new study provides an important proof-of-concept that viral replication can be substantially reduced for several weeks by a single injection of a tissue-targeted cellular microRNA antagonist, inhibiting a key component in a viral lifecycle. This result paves the way to the development of novel potent host-targeted antiviral approaches based on microRNA antagonism.
Full Text | PDF
IBD: Genetic differences in Crohn's disease susceptibility and outcome
Kajari Mondal & Subra Kugathasan
Published online: 08 March 2017
p266 | doi:10.1038/nrgastro.2017.24
A new genome-wide association study (GWAS) has been conducted to discover genetic contributions that can explain disease prognosis in Crohn's disease. This understudied area deserves attention for discovering genetic variants responsible for disease severity, as well as encouraging scientists to analyse or reanalyse GWAS data using various clinically important endophenotypes.
Full Text | PDF
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Current and emerging therapeutic targets for IBD
Markus F. Neurath
Published online: 01 February 2017
p269 | doi:10.1038/nrgastro.2016.208
The management of IBD has undergone major advances with the development of biologic agents. Here, Markus Neurath provides an overview of current and future therapeutic targets for IBD, including insights into the mechanisms and rationale behind such approaches.
Abstract | Full Text | PDF
Genetics of primary sclerosing cholangitis and pathophysiological implications
Xiaojun Jiang & Tom H. Karlsen
Published online: 15 March 2017
p279 | doi:10.1038/nrgastro.2016.154
Results from genetic studies of primary sclerosing cholangitis have identified a number of risk loci associated with the disease. Here, Jiang and Karlsen comprehensively discuss the identity and function of risk genes, the potential roles they have in pathogenesis and future research efforts.
Abstract | Full Text | PDF | Supplementary information
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Peter Storz
Published online: 08 March 2017
p296 | doi:10.1038/nrgastro.2017.12
Pancreatic acinar cells show high plasticity and can undergo acinar-to-ductal metaplasia, which might be an initiating event for pancreatic cancer. Here, the determinants of acinar cell plasticity are discussed, as well as signalling events that drive acinar-to-ductal metaplasia and their contribution to oncogenesis.
Abstract | Full Text | PDF
Article series: Techniques, technology & analysis
Advances in image enhancement in colonoscopy for detection of adenomas
Takahisa Matsuda et al.
Published online: 15 March 2017
p305 | doi:10.1038/nrgastro.2017.18
Various technologies and systems have been developed to improve adenoma detection rate during colonoscopy and thereby reduce colorectal cancer incidence. Here, Matsuda and colleagues discuss how add-on devices, colonoscope advances and image-enhanced endoscopy might assist in the detection of polyps and adenomas.
Abstract | Full Text | PDF
Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet?
Eamonn M. M. Quigley
Published online: 30 March 2017
p315 | doi:10.1038/nrgastro.2017.29
Gut microbiota research has rapidly evolved, but has yet to translate fully to the clinic. In this Perspectives, Eamonn Quigley explores whether the gut microbiota could be used as a clinical tool in gastrointestinal disease, providing a note of caution to the hype.
Abstract | Full Text | PDF
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