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Nature Cell Biology contents: May 2017 Volume 19 Number 5, pp 409 - 577

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Nature Cell Biology

Do You Know What's in Your Cell Culture? 
There might be other things on your plate than expected. Unlock some secrets of small additional steps you can take to become an expert in cell handling mastering the daily challenge of contamination prevention. www.eppendorf.com/cellexperts  

May 2017 Volume 19, Issue 5

News and Views
Technical Report
Cancer Evolution Collection

This collection highlights the most recent research and review articles published on this topic.

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Science in the age of Trump   p409
The steep cuts in science funding proposed in the 2018 US budget blueprint have raised alarm in scientific quarters, and signal the current administration's disregard for the significance of science and research in modern society.

News and Views


Terminating the replication helicase   pp410 - 412
Vincent Gaggioli and Philip Zegerman
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

See also: Article by Sonneville et al.

SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells   pp412 - 414
Tong Ming Liu and Ng Shyh-Chang
The metabolic transition from mitochondrial oxidative phosphorylation (OXPHOS) to glycolysis is critical for somatic reprogramming of induced pluripotent stem cells (iPSCs). SIRT2 has now been established as a previously unknown regulator of this metabolic transition during somatic reprogramming by controlling the acetylation status of glycolytic enzymes.

See also: Article by Cha et al.

Metabolic changes promote rejection of oncogenic cells   pp414 - 415
Jonathan L. Coloff and Joan S. Brugge
Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.

See also: Article by Kon et al.

Context-specific roles of EMT programmes in cancer cell dissemination   pp416 - 418
M. Angela Nieto
The role of the epithelial-to-mesenchymal transition in tumour progression remains a topic of intense debate. Now, data on the role of Zeb1 in the metastatic spread of pancreatic cancer clarify apparently conflicting views by revealing context-specific, differential use of individual epithelial-to-mesenchymal transition transcription factors in cancer cell dissemination.

See also: Article by Krebs et al.

When cancer needs what's non-essential   pp418 - 420
Mark R. Sullivan and Matthew G. Vander Heiden
The non-essential amino acids serine and glycine are critical for proliferative metabolism. A study in Nature now finds that dietary serine and glycine deprivation inhibits growth of some tumours. Whether this dietary intervention is effective depends on both the oncogenic context and tumour tissue of origin.

See also: Letters to Editor by Maddocks et al.

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Nature Index Japan 2017

Japan's status as a science superstar is vulnerable. Nature Index 2017 Japan reveals that although the country is still among the upper echelons of global research, its output has continued to slide.

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ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes   pp421 - 432
Georgia Chatzinikolaou, Zivkos Apostolou, Tamara Aid-Pavlidis, Anna Ioannidou, Ismene Karakasilioti et al.
Chatzinikolaou et al. show that the nucleotide excision repair complex ERCC1–XPF cooperates with the chromatin organizer CTCF, cohesin subunits and ATRX to facilitate the silencing of a subset of imprinted genes in the developing liver.

Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling   pp433 - 444
Amy Reilein, David Melamed, Karen Sophia Park, Ari Berg, Elisa Cimetta et al.
Reilein et al. demonstrate that Drosophila ovarian follicle stem cells (FSCs) produce either proliferative follicle cells or quiescent escort cells, depending on which position they occupy in the germarium and in response to graded Wnt signalling.

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis   pp445 - 456
Young Cha, Min-Joon Han, Hyuk-Jin Cha, Janet Zoldan, Alison Burkart et al.
Cha et al. show that SIRT2 suppression by miR-200c enhances acetylation levels and enzymatic activities of glycolytic enzymes and contributes to metabolic reprogramming of human induced pluripotent stem cells and human embryonic stem cells.

See also: News and Views by Liu & Shyh-Chang

Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche   pp457 - 467
Erich W. Damm and Wilson K. Clements
Damm et al. demonstrate that trunk neural crest cell migration to the dorsal aorta in zebrafish is regulated by platelet-derived growth factor (PDGF) signalling and required for haematopoietic stem cell (HSC) specification.

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis   pp468 - 479
Remi Sonneville, Sara Priego Moreno, Axel Knebel, Clare Johnson, C. James Hastie et al.
The Cdc45–MCM–GINS (CMG) complex is needed for DNA replication, but how CMG dissociates from DNA in higher eukaryotes is not clear. Sonneville et al. now characterize pathways for CMG dissociation and replication termination in worm and frog.

See also: News and Views by Gaggioli & Zegerman

Microtubule minus-end regulation at spindle poles by an ASPM–katanin complex   pp480 - 492
Kai Jiang, Lenka Rezabkova, Shasha Hua, Qingyang Liu, Guido Capitani et al.
Jiang et al. show that the microcephaly-associated protein ASPM and katanin form a complex that binds microtubule minus ends and can sever microtubules and block microtubule minus-end elongation to control spindle pole dynamics.

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division   pp493 - 503
Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Marti
Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis   pp504 - 517
Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra et al.
Sah and colleagues show that the volume-sensitive ion channel SWELL1 regulates adipocyte insulin-PI(3)K-AKT2 signalling, glucose uptake and lipid content through interactions with GRB2/Cav1.

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer   pp518 - 529
Angela M. Krebs, Julia Mitschke, Maria Lasierra Losada, Otto Schmalhofer, Melanie Boerries et al.
Adding to the recent debate on the role of epithelial–mesenchymal transition (EMT) in cancer cell invasion and metastasis, Brabletz and colleagues show that the EMT-inducing transcription factor Zeb1 drives pancreatic tumorigenesis and metastasis.

See also: News and Views by Nieto

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes   pp530 - 541
Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai et al.
Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.

See also: News and Views by Coloff & Brugge

Nature Insight: Neurodegenerative Diseases

This Insight explores brain ageing and possible rejuvenation and updates our understanding of Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. It also discusses how knowledge from prion disease may apply to more common neurodegenerative disorders and provides a structural perspective on the properties of amyloids.

Access the Insight free online

Produced with support from: Eli Lilly and Company



A three-dimensional model of human lung development and disease from pluripotent stem cells   pp542 - 549
Ya-Wen Chen, Sarah Xuelian Huang, Ana Luisa Rodrigues Toste de Carvalho, Siu-Hong Ho, Mohammad Naimul Islam et al.
Chen et al. generate lung bud organoids from human pluripotent stem cells that recapitulate early lung development, such as branching airway formation and early alveolar structures, which could potentially be used to model lung disease.

Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling   pp550 - 557
Chih-Chun Janet Lin and Meng C. Wang
Lin and Wang show that methionine deprivation reprogrammes bacterial metabolism to regulate host mitochondrial dynamics and lipid metabolism in Caenorhabditis elegans through nuclear receptor and Hedgehog signalling.



High-resolution myogenic lineage mapping by single-cell mass cytometry   pp558 - 567
Ermelinda Porpiglia, Nikolay Samusik, Andrew Tri Van Ho, Benjamin D. Cosgrove, Thach Mai et al.
Porpiglia et al. use single-cell mass cytometry to analyse surface markers and key myogenic transcription factors of skeletal muscle stem cells during homeostasis and repair, and identify previously unrecognized myogenic progenitor cell populations.

Technical Report


Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium   pp568 - 577
Margherita Y. Turco, Lucy Gardner, Jasmine Hughes, Tereza Cindrova-Davies, Maria J. Gomez et al.
Turco et al. derive long-term genetically stable organoids from normal endometrium and the decidua that recapitulate characteristics of in vivo uterine glands, respond to hormones and differentiate into secretory and ciliated endometrial cells.

April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time. 

Click here to read!
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