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dinsdag 21 maart 2017

Scientific Reports Health Sciences Table of Contents e-alert: 21 March 2017

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  21 March 2017   
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Health Sciences

Magnitude-dependent response of osteoblasts regulated by compressive stress


Xiao-qing Shen, Yuan-ming Geng, Ping Liu et al.


The present study aimed to investigate the role of magnitude in adaptive response of osteoblasts exposed to compressive stress. Murine primary osteoblasts and MC3T3-E1 cells were …


Serum lipid profiles and dyslipidaemia are associated with retinal microvascular changes in children and adolescents


Wei Xiao, Xinxing Guo, Xiaohu Ding et al.


The present study aims to assess the relationship between serum lipid parameters and retinal microvascular calibres in children and adolescents. A total of 950 participants aged …


Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening


Qiuxia Min, Xinpei Cai, Weiguang Sun et al.


The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme …


Kidney-specific transposon-mediated gene transfer in vivo


Lauren E. Woodard, Jizhong Cheng, Richard C. Welch et al.


Methods enabling kidney-specific gene transfer in adult mice are needed to develop new therapies for kidney disease. We attempted kidney-specific gene transfer following …


Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis


Shuqin Mei, Lin Li, Qingqing Wei et al.


Interstitial fibrosis, a common pathological feature of chronic kidney diseases, is often associated with apoptosis in renal tissues. To determine the associated apoptotic …


Efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy: a randomized double-blind controlled trial


Pontip Meteerattanapipat, Vorapong Phupong


The aim of this study was to compare the therapeutic efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy. A …


Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair


Chia-Lung Wu, Kelly A. Kimmerling, Dianne Little et al.


High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among …


Polyphonic sonification of electrocardiography signals for diagnosis of cardiac pathologies


Jakob Nikolas Kather, Thomas Hermann, Yannick Bukschat et al.


Electrocardiography (ECG) data are multidimensional temporal data with ubiquitous applications in the clinic. Conventionally, these data are presented visually. It is presently …


Hypertension and breast cancer risk: a systematic review and meta-analysis


Hedong Han, Wei Guo, Wentao Shi et al.


Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and …


Association between liver function and metabolic syndrome in Chinese men and women


Sen Wang, Jie Zhang, Li Zhu et al.


Metabolic syndrome (MS) could be associated with liver function. Our study aimed to investigate the association between liver function and MS in a large cohort of Chinese men and …


Inhibitory responses mediated by vagal nerve stimulation are diminished in stomachs of mice with reduced intramuscular interstitial cells of Cajal


Elizabeth A. H. Beckett, Kenton M. Sanders, Sean M. Ward


Intramuscular interstitial cells of Cajal (ICC-IM) are closely associated with enteric motor nerve terminals and electrically coupled to smooth muscle cells within the gastric …


Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance


Toshiya Matsukawa, Hideko Motojima, Yuki Sato et al.


Regular exercise and physical training enhance physiological capacity and improve metabolic diseases. Skeletal muscles require peroxisome proliferator-activated receptor-gamma …


KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress


Masayuki Hata, Hanako O. Ikeda, Chinami Kikkawa et al.


Ischemic neural damages cause several devastating diseases, including brain stroke and ischemic retinopathies, and endoplasmic reticulum (ER) stress has been proposed to be the …


Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)


Benjamin L. Farah, Rohit A. Sinha, Yajun Wu et al.


Glycogen storage disease type Ia (GSDIa, von Gierke disease) is the most common glycogen storage disorder. It is caused by the deficiency of glucose-6-phosphatase, an enzyme …


Functional conservation and coherence of HIV-1 subtype A Vpu alleles


Bizhan Romani, Amirarsalan Kavyanifard, Elham Allahbakhshi


Functional studies of HIV-1 proteins are normally conducted using lab adapted strains of HIV-1. The extent of those functions in clinical strains is sometimes unknown. In this …


Genetic association between the cyclin-dependent kinase inhibitor gene p27/Kip1 polymorphism (rs34330) and cancer susceptibility: a meta-analysis


Xiao-Ke Cheng, Xue-Jun Wang, Xiao-Dong Li et al.


The p27 rs34330 (-79C/T) polymorphism has been widely studied for human cancer susceptibility. The current findings, however, still remained controversial. Therefore, we …


Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease


Hong-Ling Jia, Chao-Wu Liu, Li Zhang et al.


Although Kawasaki disease is the main cause of acquired heart disease in children, no diagnostic biomarkers are available. We aimed to identify candidate biomarkers for …


Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models


Mira Valkonen, Pekka Ruusuvuori, Kimmo Kartasalo et al.


Cancer involves histological changes in tissue, which is of primary importance in pathological diagnosis and research. Automated histological analysis requires ability to …


Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica


Xiang Yu, Xuhang Li, Lina Zheng et al.


RNaseIII proteins are dsRNA-specific endonucleases involved in many important biological processes, such as small RNA processing and maturation in eukaryotes. Various small RNAs …


A smartphone-based diagnostic platform for rapid detection of Zika, chikungunya, and dengue viruses


Aashish Priye, Sara W. Bird, Yooli K. Light et al.


Current multiplexed diagnostics for Zika, dengue, and chikungunya viruses are situated outside the intersection of affordability, high performance, and suitability for use at the …


Enterohemorrhagic Escherichia coli pathogenesis: role of Long polar fimbriae in Peyer’s patches interactions


Charlotte Cordonnier, Lucie Etienne-Mesmin, Jonathan Thévenot et al.


Enterohemorrhagic Escherichia coli (EHEC) are major food-borne pathogens whose survival and virulence in the human digestive tract remain unclear owing to paucity of relevant …


Cyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents


Chun-Kuang Lin, Chin-Kai Tseng, Yu-Hsuan Wu et al.


Cyclooxygenase-2 (COX-2) is one of the important mediators of inflammation in response to viral infection, and it contributes to viral replication, for example, cytomegalovirus …


Effects of exercise-based cardiac rehabilitation in patients after percutaneous coronary intervention: A meta-analysis of randomized controlled trials


Xinyu Yang, Yanda Li, Xiaomeng Ren et al.


In this study, we assessed the effect of rehabilitation exercise after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). We performed a …


Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing


Maria Rovithi, Amir Avan, Niccola Funel et al.


The aim of the present study was to develop chick-embryo chorioallantoic membrane (CAM) bioluminescent tumor models employing low passage cell cultures obtained from primary …


TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance


Wenjing Li, Xiaoyan Yang, Tao Zheng et al.


Persistent elevation of plasma TNF-α is a marker of low grade systemic inflammation. Palmitic acid (PA) is the most abundant type of saturated fatty acid in human body. PA is …


Establishment of a novel cellular model for myxofibrosarcoma heterogeneity


Birgit Lohberger, Nicole Stuendl, Andreas Leithner et al.


Human cancers frequently display substantial intra-tumoural heterogeneity in virtually all distinguishable phenotypic features, such as cellular morphology, gene expression, and …


Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis


Chikara Komiya, Miyako Tanaka, Kyoichiro Tsuchiya et al.


Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) is an orally bioavailable pyridone …


Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage


Hsin-Hsi Tsai, Li-Kai Tsai, Ya-Fang Chen et al.


The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to …


Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice


Kathrin Koenen, Isabell Knepper, Madlen Klodt et al.


Elevated peak bone mass in early adulthood reduces the risk for osteoporotic fractures at old age. As sports participation has been correlated with elevated peak bone masses, we …


Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea


Mona F. Philby, Paul M. Macey, Richard A. Ma et al.


Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA …


Identification of novel chemotherapeutic strategies for metastatic uveal melanoma


Paolo Fagone, Rosario Caltabiano, Andrea Russo et al.


Melanoma of the uveal tract accounts for approximately 5% of all melanomas and represents the most common primary intraocular malignancy. Despite improvements in diagnosis and …


External validation of a COPD prediction model using population-based primary care data: a nested case-control study


Bright I Nwaru, Colin R Simpson, Aziz Sheikh et al.


Emerging models for predicting risk of chronic obstructive pulmonary disease (COPD) require external validation in order to assess their clinical value. We validated a previous …


Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats


Chun Yi, Ke-Yi Hao, Ting Ma et al.


The bone mineral deficiency in osteoporosis poses a threat to the long-term outcomes of endosseous implants. The inhibitors of cathepsin K (CatK) significantly affect bone …


Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats


Feng Gao, Pengyuan Liu, Jayashree Narayanan et al.


We used a rat model of whole thorax x-ray irradiation to profile the microRNA (miRNA) in lung and blood up to 4 weeks after radiation. MiRNA from normal and irradiated Wistar rat …


Transient desialylation in combination with a novel antithrombin deficiency causing a severe and recurrent thrombosis despite anticoagulation therapy


Nuria Revilla, María Eugenia de la Morena-Barrio, Antonia Miñano et al.


An in-depth focused study of specific cases of patients with recurrent thrombosis may help to identify novel circumstances, genetic and acquired factors contributing to the …


Relationships between strength and endurance parameters and air depletion rates in professional firefighters


Stephanie Windisch, Wolfgang Seiberl, Ansgar Schwirtz et al.


The aim of this study was to quantify the physical demands of a simulated firefighting circuit and to establish the relationship between job performance and endurance and …


Altered microstructure rather than morphology in the corpus callosum after lower limb amputation


Zhichao Li, Chuanming Li, Lingzhong Fan et al.


The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. …


Dependence of nighttime sleep duration in one-month-old infants on alterations in natural and artificial photoperiod


Sachiko Iwata, Fumie Fujita, Masahiro Kinoshita et al.


Human sleep–wake cycles are entrained by both natural and artificial light–dark cycles. However, little is known regarding when and how the photoperiod changes entrain the …


Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy


Yuekui Zhao, Shanshan Tang, Jiamin Guo et al.


Poor antigenic presentation of tumor tissues and a lack of specific targets currently limit the success of nanoparticle delivery system. Cellular carrier technique has been …


Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms


Saleh Yazdani, Fariba Poosti, Luis Toro et al.


Excessive lymphangiogenesis is associated with cancer progression and renal disease. Attenuation of lymphangiogenesis might represent a novel strategy to target disease …


Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice


Ruirui Wu, Xiafang Wu, Huihui Wang et al.


Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility and metabolism. Mouse strain variability may provide a better …


An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes


Xiao-Ting Huang, Chen Li, Xiang-Ping Peng et al.


In the nervous system, excessive activation of NMDA receptors causes neuronal injury. Although activation of NMDARs has been proposed to contribute to the progress of diabetes, …


HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3


Qing Liang, Kejia Wang, Bin Wang et al.


Glioblastoma (GBM) is the most prevalent and lethal type of primary malignant brain tumour. Recent studies suggest that the discovery of human cytomegalovirus (HCMV)-encoded …


Effects of matrix stiffness on epithelial to mesenchymal transition-like processes of endometrial epithelial cells: Implications for the pathogenesis of endometriosis


Sachiko Matsuzaki, Claude Darcha, Jean-Luc Pouly et al.


Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites. Our previous study revealed an epithelial to mesenchymal transition …


Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers


Cecilia Rossetti, Magdalena A. Świtnicka-Plak, Trine Grønhaug Halvorsen et al.


Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform …


Phospholipid imprinted polymers as selective endotoxin scavengers


Robert Sulc, Gyorgy Szekely, Sudhirkumar Shinde et al.


Herein we explore phospholipid imprinting as a means to design receptors for complex glycolipids comprising the toxic lipopolysaccharide endotoxin. A series of polymerizable …


Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs


Yongchu Pan, Hongliang Liu, Yanru Wang et al.


mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 …


HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy


Priyanka Banerjee, Abhijit Chakraborty, Rajiv Kumar Mondal et al.


The present study sought to evaluate the structure of HBV quasispecies in Lamivudine (LMV)-failed chronic hepatitis B (CHB) patients and its impact in defining the subsequent …


Effect of 1.8 GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice


Kai Wang, Jun-Mei Lu, Zhen-He Xing et al.


Mounting evidence suggests that exposure to radiofrequency electromagnetic radiation (RF-EMR) can influence learning and memory in rodents. In this study, we examined the effects …


A novel toolbox to investigate tissue spatial organization applied to the study of the islets of Langerhans


Hoa Tran Thi Nhu, Rafael Arrojo E. Drigo, Per-Olof Berggren et al.


Thanks to the development of new 3D Imaging techniques, volumetric data of thick samples, especially tissues, are commonly available. Several algorithms were proposed to analyze …


CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage


Yannick F. Fuchs, Anne Eugster, Sevina Dietz et al.


CD8+ T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8+ T cells …


FOXO transcription factors protect against the diet-induced fatty liver disease


Xiaoyan Pan, Yang Zhang, Hyeong-Geug Kim et al.


Forkhead O transcription factors (FOXOs) have been implicated in glucose and lipid homeostasis; however, the role of FOXOs in the development of nonalcoholic fatty liver disease …


Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea


Noelia Campillo, Marta Torres, Antoni Vilaseca et al.


An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) …


Role of purinergic signaling in experimental pneumococcal meningitis


Marco Zierhut, Susanne Dyckhoff, Ilias Masouris et al.


Excessive neutrophilic inflammation contributes to brain pathology and adverse outcome in pneumococcal meningitis (PM). Recently, we identified the NLRP3 inflammasome/interleukin …


Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort


Hyewon Lee, Woojae Myung, Doh Kwan Kim et al.


Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological …


Corrigendum: Paper-based CRP Monitoring Devices


Shang-Chi Lin, Chung-Yuh Tzeng, Po-Liang Lai et al.



Corrigendum: The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease


Samantha Cialfi, Loredana Le Pera, Carlo De Blasio et al.



Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer


Wei Song, Lin Tang, Yumei Xu et al.



Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats


Zhihong Ma, Li Chu, Hongying Liu et al.


Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver diseases. This study sought to evaluate the insulin-sensitizing effect of paeoniflorin (PF) …


Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice


Kun Zhang, Yu-jiao Li, Dan Feng et al.


Sleep disorder is becoming a widespread problem in current society, and is associated with impaired cognition and emotional disorders. Progranulin (PGRN), also known as granulin …


Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease


Wenjing Luo, Qinyu Xu, Qi Wang et al.


Abnormal lipid-mediated hepatic inflammatory-immune dysfunction and chronic low grade inflammation play an important role in the pathogenesis of non-alcoholic fatty liver disease …


A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation


Mihaela Ghita, Stephen J. McMahon, Laura E. Taggart et al.


Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study …


Corrigendum: Prognostic value of pulmonary congestion assessed by lung ultrasound imaging during heart failure hospitalisation: A two-centre cohort study


Stefano Coiro, Guillaume Porot, Patrick Rossignol et al.



Volume-sensitive outwardly rectifying chloride channel blockers protect against high glucose-induced apoptosis of cardiomyocytes via autophagy activation


Lin Wang, Mingzhi Shen, Xiaowang Guo et al.


Hyperglycemia is a well-characterized contributing factor for cardiac dysfunction and heart failure among diabetic patients. Apoptosis of cardiomyocytes plays a major role during …


White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke


Laura Otero-Ortega, Fernando Laso-García, María del Carmen Gómez-de Frutos et al.


Mesenchymal stem cells have previously been shown to mediate brain repair after stroke; they secrete 50–100 nm complexes called extracellular vesicles (EVs), which could be …


Quantum-dot-based suspension microarray for multiplex detection of lung cancer markers: preclinical validation and comparison with the Luminex xMAP® system


Regina Bilan, Amagoia Ametzazurra, Kristina Brazhnik et al.


A novel suspension multiplex immunoassay for the simultaneous specific detection of lung cancer markers in bronchoalveolar lavage fluid (BALF) clinical samples based on …


Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle


Lawrence Vernetti, Albert Gough, Nicholas Baetz et al.



Renal Medulla is More Sensitive to Cisplatin than Cortex Revealed by Untargeted Mass Spectrometry-Based Metabolomics in Rats


Pei Zhang, Jia-Qing Chen, Wan-Qiu Huang et al.


Nephrotoxicity has long been the most severe and life-threatening side-effect of cisplatin, whose anticancer effect is therefore restricted. Previous pathological studies have …


Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production


Róbert Bátori, Bálint Bécsi, Dénes Nagy et al.


The inhibitory phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) at Thr497 (eNOSpThr497) by protein kinase C or RhoA-activated kinase is a major regulatory …


Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet


Li Zhang, Daniel Andersen, Henrik Munch Roager et al.


Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our …


Structure-symptom relationship with wide-area ultrasound scanning of knee osteoarthritis


Jana Podlipská, Juhani M. Koski, Päivi Kaukinen et al.


The aetiology of knee pain in osteoarthritis (OA) is heterogeneous and its relationship with structural changes and function is unclear. Our goal was to determine the prevalence …


Correlations between TBL1XR1 and recurrence of colorectal cancer


Hongda Liu, Yunfei Xu, Qun Zhang et al.


More than 25% localized CRC patients died from post-operative metastasis, and risk of metastasis varies among individuals due to the high heterogeneity of CRC. Therefore, …


Microstructural changes are coincident with the improvement of clinical symptoms in surgically treated compressed nerve roots


Weifei Wu, Jie Liang, Ying Chen et al.


Diffusion tensor imaging (DTI) has been widely used to visualize peripheral nerves, but the microstructure of compressed nerve roots can be assessed using DTI. However, there are …


Six Out of Ten Women with Recurrent Urinary Tract Infections Complain of Distressful Sexual Dysfunction – A Case-Control Study


Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia et al.


Uncomplicated recurrent urinary tract infections (rUTIs) are common among reproductive-aged women. We aimed to assess the prevalence and predictors of sexual dysfunction (FSD) in …


Neurophysiological and BOLD signal uncoupling of giant somatosensory evoked potentials in progressive myoclonic epilepsy: a case-series study


Silvia F. Storti, Alessandra Del Felice, Laura Canafoglia et al.


In progressive myoclonic epilepsy (PME), a rare epileptic syndrome caused by a variety of genetic disorders, the combination of peripheral stimulation and functional magnetic …


To Find a Better Dosimetric Parameter in the Predicting of Radiation-Induced Lung Toxicity Individually: Ventilation, Perfusion or CT based


Lin-Lin Xiao, Guoren Yang, Jinhu Chen et al.


This study aimed to find a better dosimetric parameter in predicting of radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) individually: …


Diagnostic Application of Targeted Next-Generation Sequencing of 80 Genes Associated with Disorders of Sexual Development


Yanjie Fan, Xia Zhang, Lili Wang et al.


Disorders of sexual development (DSD) are estimated to occur in 1 of 4500 births. Since the genetic etiology of DSD is highly heterogeneous, obtaining a definitive molecular …


Salvage Liver Transplantation Leads to Poorer Outcome in Hepatocellular Carcinoma Compared with Primary Liver Transplantation


Yuhua Shan, Lifeng Huang, Qiang Xia


Hepatocellular carcinoma is the most common liver malignancy. Salvage liver transplantation (SLT) is viewed as a feasible cure for recurrence of HCC after resectomy, but the …


Chlorin e6 mediated photodynamic inactivation for multidrug resistant Pseudomonas aeruginosa keratitis in mice in vivo


Ming-Feng Wu, Mona Deichelbohrer, Thomas Tschernig et al.


Following corneal epithelium scratches, mouse corneas were infected with the multidrug resistant (MDR) P. aeruginosa strain PA54. 24 hours later, 0% (for control group), 0.01%, …


Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study


Kazutaka Ohi, Takamitsu Shimada, Hiroaki Kihara et al.


Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and …


Nightmares as predictors of suicide: an extension study including war veterans


Nils Sandman, Katja Valli, Erkki Kronholm et al.


Nightmares are intensive dreams with negative emotional tone. Frequent nightmares can pose a serious clinical problem and in 2001, Tanskanen et al. found that nightmares increase …


Dietary patterns and the risk of rhinitis in primary school children: a prospective cohort study


Xudong Liu, Claudie Chiu-Yi Wong, Ignatius T. S. Yu et al.


This study was to investigate the association between dietary patterns and rhinitis in primary school children. 1,599 students without rhinitis at baseline survey were selected …


Oral health in relation to all-cause mortality: the IPC cohort study


Margaux Adolph, Christelle Darnaud, Frédérique Thomas et al.


We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16–89 years at recruitment. The mean follow-up time was …


Mitigation Effect of Proanthocyanidin on Secondary Heart Injury in Rats Caused by Mechanical Trauma


Shuo Ma, Chong Chen, Tingting Cao et al.


Multiple organ dysfunctional syndrome secondary to mechanical trauma (MT) has attracted considerable research attention. The heart is one of the most important organs of the …


Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS


Rosemary M. Clark, Catherine A. Blizzard, Kaylene M. Young et al.


Increasing evidence indicates an excitatory/inhibitory imbalance may have a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Impaired inhibitory …


Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7


Riccardo Pofi, Daniela Fiore, Rita De Gaetano et al.


Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN …


Analysis of RP2 and RPGR Mutations in Five X-Linked Chinese Families with Retinitis Pigmentosa


Jingjing Jiang, Xiaofei Wu, Di Shen et al.


Mutations in RP2 and RPGR genes are responsible for the X-linked retinitis pigmentosa (XLRP). In this study, we analyzed the RP2 and RPGR gene mutations in five Han Chinese …


Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation


Yitao Wang, Chunxue Zhang, Yuelei Jin et al.


ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional …


Efficient digitalization method for dental restorations using micro-CT data


Changhwan Kim, Seung Hoon Baek, Taewon Lee et al.


The objective of this study was to demonstrate the feasibility of using micro-CT scan of dental impressions for fabricating dental restorations and to compare the dimensional …


Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon


Hokahiro Katayama, Kentaro Yasuchika, Yuya Miyauchi et al.


Somatic cells can be reprogrammed to induced hepatocyte-like cells (iHeps) by overexpressing certain defined factors in direct reprogramming techniques. Of the various methods to …


Improved shear wave motion detection using coded excitation for transient elastography


Xiao-Nian He, Xian-Fen Diao, Hao-Ming Lin et al.


Transient elastography (TE) is well adapted for use in studying liver elasticity. However, because the shear wave motion signal is extracted from the ultrasound signal, the weak …


Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region


Isabel María Díaz Lozano, Luis Miguel De Pablos, Silvia Andrea Longhi et al.


The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of …


Cardiac repair in a mouse model of acute myocardial infarction with trophoblast stem cells


Guannan Li, Jianzhou Chen, Xinlin Zhang et al.


Various stem cells have been explored for the purpose of cardiac repair. However, any individual stem cell population has not been considered as the ideal source. Recently, …


Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A2B pathway


Claire Doyle, Vivian Cristofaro, Bryan S. Sack et al.


Neurogenic detrusor overactivity (NDO) is among the most challenging complications of spinal cord injury (SCI). A recent report by us demonstrated an improvement in NDO in SCI …


Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism


Tomoyuki Murano, Hisatsugu Koshimizu, Hideo Hagihara et al.


Alcoholism, which is defined as the recurring harmful use of alcohol despite its negative consequences, has a lifetime prevalence of 17.8%. Previous studies have shown that …


Network analysis reveals crosstalk between autophagy genes and disease genes


Ji-Ye Wang, Wei-Xuan Yao, Yun Wang et al.


Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for degradation. …


Aptamer-based Field-Effect Biosensor for Tenofovir Detection


N. Aliakbarinodehi, P. Jolly, N. Bhalla et al.


During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address …


Corrigendum: Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation


Alessandra Tammaro, Jesper Kers, Diba Emal et al.



Crystallization and hardening of poly(ethylene-co-vinyl acetate) mouthguards during routine use


Ryoko Kuwahara, Ryotaro Tomita, Natsumi Ogawa et al.


Mouthguards (MGs) made from poly(ethylene-co-vinyl acetate) (EVA) are widely used in contact sports to prevent injuries such as breaking teeth and lip lacerations and to reduce …


The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury


Fei-Juan Kong, Jia-Hua Wu, Shui-Ya Sun et al.


Lipotoxicity has been implicated in pancreatic β-cell dysfunction in type 2 diabetes, but the exact mechanisms remain unknown. The current study explored the role of the …


Asymmetric dimethylarginine and all-cause mortality: a systematic review and meta-analysis


Shaoli Zhou, Qianqian Zhu, Xiang Li et al.


Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), impairs the beneficial effect of NO. The predictive value of ADMA for all-cause …


Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning


Clémence Girardet, Maria M. Mavrikaki, Joseph R. Stevens et al.


Melanocortin-3 receptors (MC3R) have a contextual role in appetite control that is amplified with hypocaloric conditioning. C57BL/6J (B6) mice subjected to hypocaloric feeding …


Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer


Graciele C. M. Manica, Caroline F. Ribeiro, Marco A. S. de Oliveira et al.


Breast cancer is a heterogeneous disease with differences in its clinical, molecular and biological features. Traditionally, immunohistochemical markers together with …


Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain


Jiafu Wang, Jianghui Meng, Marc Nugent et al.


Botulinum neurotoxins (BoNTs) are the most toxic proteins known, due to inhibiting the neuronal release of acetylcholine and causing flaccid paralysis. Most BoNT serotypes target …


Corrigendum: Evaluation of the Bone-ligament and tendon insertions based on Raman spectrum and its PCA and CLS analysis


Yang Wu, Yu Dong, Jia Jiang et al.



An outbreak of severe infections among Australian infants caused by a novel recombinant strain of human parechovirus type 3


Tiffanie M. Nelson, Peter Vuillermin, Jason Hodge et al.


Human parechovirus types 1–16 (HPeV1–16) are positive strand RNA viruses in the family Picornaviridae. We investigated a 2015 outbreak of HPeV3 causing illness in infants in …


CT-guided versus laparoscopic radiofrequency ablation in recurrent small hepatocellular carcinoma against the diaphragmatic dome


Huaiyin Ding, Mu Su, Chuandong Zhu et al.


Computed tomography-guided radiofrequency ablation (CT-RFA) and laparoscopic RFA (L-RFA) have been used to treat intrahepatic recurrent small hepatocellular carcinoma (HCC) …


Investigation on treatment strategy, prognostic factors, and risk factors for early death in elderly Taiwanese patients with diffuse large B-cell lymphoma


Shih-Feng Cho, Yi-Chang Liu, Hui-Hua Hsiao et al.


This study aimed to investigate the treatment strategy, prognostic factors, and risk factors of early death in elderly patients (age ≥ 65 years) with diffuse large B-cell …


Influence of ad Libitum Feeding of Piglets With Bacillus Subtilis Fermented Liquid Feed on Gut Flora, Luminal Contents and Health


Yuyong He, Chunxia Mao, Hong Wen et al.


Some scholars caution that long-term ad libitum feeding with probiotic fermented food poses potential health risks to baby animals. We conducted a feeding experiment to …


Overexpression of decorin promoted angiogenesis in diabetic cardiomyopathy via IGF1R-AKT-VEGF signaling


Jinsheng Lai, Fuqiong Chen, Jing Chen et al.


Microcirculatory dysfunction is believed to play an important role in diabetic cardiomyopathy. The small leucine-rich proteoglycan decorin is generally considered a …


Identifying Life-Threatening Admissions for Drug Dependence or Abuse (ILIADDA): Derivation and Validation of a Model.


Tri-Long Nguyen, Thierry Boudemaghe, Géraldine Leguelinel-Blache et al.


Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-threatening hospital …


Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice


Line Fisker Zachariassen, Lukasz Krych, Kåre Engkilde et al.


Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates …


A retrospective cohort study to quantify the contribution of health systems to child survival in Kenya: 1996–2014


Rebecca Anthopolos, Ryan Simmons, Wendy Prudhomme O’Meara


Globally, the majority of childhood deaths in the post-neonatal period are caused by infections that can be effectively treated or prevented with inexpensive interventions …


Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals


Claudia Menzaghi, Antonella Marucci, Alessandra Antonucci et al.


In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine “resistin pathway”. We investigated whether …


Corrigendum: The citrus flavanone naringenin impairs dengue virus replication in human cells


Sandra Frabasile, Andrea Cristine Koishi, Diogo Kuczera et al.



Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE−/− mice


Marco Busnelli, Stefano Manzini, Mika Hilvo et al.


The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in …


Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl4-induced liver fibrogenesis mouse model


Büsra Öztürk Akcora, Gert Storm, Jai Prakash et al.


Hepatic fibrosis, a progressive chronic disease mainly caused by hepatitis viral infections, alcohol abuse or metabolic syndrome leading to liver dysfunction and is the growing …


Analysis of SOD1 mutations in a Chinese population with amyotrophic lateral sclerosis: a case-control study and literature review


QianQian Wei, QingQing Zhou, YongPing Chen et al.


Although the copper/zinc superoxide dismutase-1 (SOD1) gene has been identified in both familial ALS (FALS) and sporadic ALS (SALS), it has rarely been studied in Chinese …


Cardiac Autonomic Alteration and Metabolic Syndrome: An Ambulatory ECG-based Study in A General Population


Yan Ma, Ping-Huei Tseng, Andrew Ahn et al.


Metabolic syndrome (MetS) has been associated with chronic damage to the cardiovascular system. This study aimed to evaluate early stage cardiac autonomic dysfunction with …


Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data


Carl-Magnus Svensson, Bianca Hoffmann, Ingo M. Irmler et al.


The use of animal models of arthritis is a key component in the evaluation of therapeutic strategies against the human disease rheumatoid arthritis (RA). Here we present …


Inhibition of leukotriene B4 receptor 1 attenuates lipopolysaccharide-induced cardiac dysfunction: role of AMPK-regulated mitochondrial function


Meng Sun, Rui Wang, Qinghua Han


Leukotriene B4 (LTB4)-mediated leukocyte recruitment and inflammatory cytokine production make crucial contributions to chronic inflammation and sepsis; however, the role of LTB4 …


The development of loop-mediated isothermal amplification (LAMP) assays for the rapid authentication of five forbidden vegetables in strict vegetarian diets


Meng-Shiou Lee, Ting-Ying Su, Yi-Yang Lien et al.


Plant-based food ingredients such as garlic, Chinese leek, Chinese onion, green onion and onion are widely used in many cuisines around the world. However, these ingredients …


Continuous-flow DNP polarizer for MRI applications at 1.5 T


V. Denysenkov, M. Terekhov, R. Maeder et al.


Here we describe a new hyperpolarization approach for magnetic resonance imaging applications at 1.5 T. Proton signal enhancements of more than 20 were achieved with a newly …


Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients


Jijing Shi, Juanjuan Zhao, Xin Zhang et al.


Natural killer (NK) cells can induce liver fibrosis remission by killing hepatic stellate cells (HSCs) and producing interferon (IFN)-γ in a mouse model; however, their …


Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient


Masaya Shimojima, Shinsuke Yuasa, Chikaaki Motoda et al.


Alteration of the nuclear Ca2+ transient is an early event in cardiac remodeling. Regulation of the nuclear Ca2+ transient is partly independent of the cytosolic Ca2+ transient …


ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells


Hyun-Joo Lee, Si-Na Kim, Myung-Shin Jeon et al.


Mesenchymal stem cells (MSCs) can modulate lymphocyte proliferation and function. One of the immunomodulatory functions of MSCs involves CD4+CD25+FoxP3+ regulatory T cells …


Positive Association between Urinary Concentration of Phthalate Metabolites and Oxidation of DNA and Lipid in Adolescents and Young Adults


Chien-Yu Lin, Pau-Chung Chen, Chia-Jung Hsieh et al.


Phthalate has been used worldwide in various products for years. Little is known about the association between phthalate exposure and biomarkers of oxidative stress in …


Disease dynamics in a stochastic network game: a little empathy goes a long way in averting outbreaks


Ceyhun Eksin, Jeff S. Shamma, Joshua S. Weitz


Individuals change their behavior during an epidemic in response to whether they and/or those they interact with are healthy or sick. Healthy individuals may utilize protective …

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