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woensdag 22 maart 2017

Nature Reviews Rheumatology - Table of Contents alert Volume 13 Issu 4

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Nature Reviews Rheumatology

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April 2017 Volume 13 Number 4
Nature Reviews Rheumatology cover
2015 2-year Impact Factor 10.531 Journal Metrics 2-year Median 7
In this issue
Research Highlights
News and Views

Also this month
 Featured article:
What rheumatologists need to know about CRISPR/Cas9
Gary J. Gibson & Maozhou Yang

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Rheumatoid arthritis: New player in RA pathogenesis brought to light
Published online: 16 February 2017
p195 | doi:10.1038/nrrheum.2017.19


Acute inflammatory arthritis: Potential therapies for chikungunya arthritis
Published online: 16 February 2017
p196 | doi:10.1038/nrrheum.2017.21


Inflammation: Hit the DEK!
Published online: 23 February 2017
p196 | doi:10.1038/nrrheum.2017.25


Experimental arthritis: Do you want to treat arthritis? IDO2!
Published online: 09 March 2017
p196 | doi:10.1038/nrrheum.2017.33


Spondyloarthropathies: E. coli links IBD to spondyloarthritis
Published online: 23 February 2017
p198 | doi:10.1038/nrrheum.2017.26


Systemic sclerosis: Antifibrotic effects of PDE4 blockade?
Published online: 09 March 2017
p198 | doi:10.1038/nrrheum.2017.34



Rheumatoid arthritis: The lung as a site for anti-CCP generation? | Vasculitis syndromes: Shared genetic risk for Behçet disease and Crohn's disease | Rheumatoid Arthritis: Sirukumab effective in patients refractory to anti-TNF therapy | Rheumatoid Arthritis: Baricitinib more effective than adalimumab

Nature Reviews Rheumatology
JOBS of the week
Associate Managing Editor - Infectious Diseases, Immunology and Rheumatology
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Nature Reviews Rheumatology
International Conference on Osteoporosis, Arthritis and Musculoskeletal Disorders
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More science events from
Spondyloarthropathies: Fine tuning the management of axial spondyloarthritis
Daniel Wendling & Clément Prati
Published online: 23 February 2017
p199 | doi:10.1038/nrrheum.2017.24
Updated recommendations for the management of axial spondyloarthritis provide a useful framework for physicians treating this disease. However, the guidance on use of biologic therapies and treat-to-target strategies seems to raise more questions than it answers.
Full Text | PDF

Gout: Risk of premature death in gout unchanged for years
Chang-Fu Kuo & Shue-Fen Luo
Published online: 02 March 2017
p200 | doi:10.1038/nrrheum.2017.27
The increased risk of mortality in patients with gout is increasingly recognized, and multiple guidelines call for better management of this disease and its comorbidities. A new study, however, has found that excess mortality in patients with gout has remained unchanged since 1999.
Full Text | PDF

Connective tissue diseases: Sjögren syndrome genetics vary according to ancestry
Tove Ragna Reksten & Roland Jonsson
Published online: 09 March 2017
p202 | doi:10.1038/nrrheum.2017.36
A pioneering new study scrutinising the genetic aetiology of Sjögren syndrome across different ancestries and clinical subtypes shows that the striking heterogeneity of associations observed in Sjögren syndrome cannot be explained by subphenotype differences alone.
Full Text | PDF | Supplementary information

What rheumatologists need to know about CRISPR/Cas9
Gary J. Gibson & Maozhou Yang
Published online: 09 February 2017
p205 | doi:10.1038/nrrheum.2017.6
This Review outlines what a rheumatologist needs to know about the development and advances in CRISPR/Cas9 genome editing technologies. The authors discuss the direct applications to rheumatic diseases, which are currently limited but are certain to increase rapidly in the near future.
Abstract | Full Text | PDF

Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
Michael Croft & Richard M. Siegel
Published online: 09 March 2017
p217 | doi:10.1038/nrrheum.2017.22
In this Review, the authors discuss the function of the TNF and TNF receptor superfamily, their role in rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus, and how current knowledge is being translated into potential disease therapies.
Abstract | Full Text | PDF

The emerging safety profile of JAK inhibitors in rheumatic disease
Kevin L. Winthrop
Published online: 02 March 2017
p234 | doi:10.1038/nrrheum.2017.23
Janus kinase (JAK) inhibitors are emerging therapeutic agents for the treatment of rheumatic inflammatory diseases. In this Review, the author outlines the safety profile of JAK inhibitors, discussing the potential adverse effects associated with these drugs, such as malignancy, infections and reactivation of herpes zoster.
Abstract | Full Text | PDF

Haematopoietic stem cell transplantation for autoimmune diseases
Joost F. Swart, Eveline M. Delemarre, Femke van Wijk, Jaap-Jan Boelens, Jürgen Kuball, Jacob M. van Laar & Nico M. Wulffraat
Published online: 23 February 2017
p244 | doi:10.1038/nrrheum.2017.7
In this Review, the authors discuss the therapeutic application of haematopoietic stem cell transplantation in different autoimmune diseases, describing the immunological mechanisms and the risks and benefits of this procedure.
Abstract | Full Text | PDF

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Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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