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donderdag 16 maart 2017

Nature Reviews Nephrology - Table of Contents alert Volume 13 Issue 4

Nature Reviews Nephrology

Poster on effects of new antidiabetic drugs on cardiovascular health

This poster summarizes cardiovascular outcome trials of newly developed glucose-lowering agents. Some of these drugs have shown cardiovascular benefit that might have clinical importance in the management of type 2 diabetes. 

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Supported by an educational grant from Novo Nordisk
April 2017 Volume 13 Number 4Advertisement
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2015 2-year Impact Factor 9.463 Journal Metrics 2-year Median 8
In this issue
Research Highlights
News and Views
Consensus Statement

Also this month
 Featured article:
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Lakhmir S. Chawla et al. on behalf of the Acute Disease Quality Initiative Workgroup 16.

Key Advances in Medicine eBook from Nature Reviews - FREE to download! 

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Genetics: SGPL1 mutations cause a novel SRNS syndrome
Published online: 20 February 2017
p191 | doi:10.1038/nrneph.2017.19


Kidney cancer: CCR4: a new target for RCC
Published online: 13 February 2017
p192 | doi:10.1038/nrneph.2017.14


Hyponatraemia: Unfolding osmotic demyelination
Published online: 13 February 2017
p192 | doi:10.1038/nrneph.2017.15


Acute kidney injury: Benefits of blocking fructokinase
Published online: 27 February 2017
p192 | doi:10.1038/nrneph.2017.23


Hypertension: Thrombin amplification loop in hypertension
Published online: 20 February 2017
p193 | doi:10.1038/nrneph.2017.18


Cystic kidney disease: PALS1 links polarity, TGF-β and the Hippo pathway
Published online: 20 February 2017
p193 | doi:10.1038/nrneph.2017.20


Diabetic nephropathy: Lipid toxicity drives renal disease
Published online: 27 February 2017
p194 | doi:10.1038/nrneph.2017.22



Chronic kidney disease: Skin sodium linked to left ventricular hypertrophy | Stones: A novel approach to stone prevention in cystinuria | Dialysis: Efficacy of tenapanor in hyperphosphataemia | Vasculitis: Abberrant glycosylation alters MPO antigenicity

Nature Reviews Nephrology
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Hypertension: From GWAS to functional genomics-based precision medicine
David L. Mattson & Mingyu Liang
Published online: 06 March 2017
p195 | doi:10.1038/nrneph.2017.21
Several recent studies have provided insights into the genetic regulation of blood pressure. A new study extends these findings by coupling genome-wide association study data with functional validation approaches to identify and explore loci associated with blood pressure, and by generating a genetic risk score model to predict future cardiovascular risk.
Full Text | PDF

Transplantation: Desensitization and survival in kidney transplant recipients
Caner Süsal & Gerhard Opelz
Published online: 06 March 2017
p196 | doi:10.1038/nrneph.2017.24
Elimination of donor-specific antibodies against HLA has been used to enable transplantation of HLA-incompatible kidneys from living donors. In contrast to two previous US studies, a UK study now reports that desensitization does not offer a survival benefit over remaining on the waitlist for a compatible organ.
Full Text | PDF

Glomerular disease: Crescentic glomerulonephritis: beyond the immune system
Philip Webster & Charles Pusey
Published online: 16 March 2017
p198 | doi:10.1038/nrneph.2017.32
T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells.
Full Text | PDF

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease
Ton J. Rabelink, Bernard M. van den Berg, Marjolein Garsen, Ganqi Wang, Michael Elkin & Johan van der Vlag
Published online: 06 February 2017
p201 | doi:10.1038/nrneph.2017.6
Heparanase is an endoglycosidase that regulates numerous cell functions and is able to degrade the extracellular matrix component heparan sulfate, which has a key role in maintaining the integrity of the glomerular filtration barrier. In this Review, Rabelink and colleagues describe the biological regulation and functions of heparanase, including the role of this enzyme in the development of kidney disease.
Abstract | Full Text | PDF

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
Kathleen A. Hershberger, Angelical S. Martin & Matthew D. Hirschey
Published online: 06 February 2017
p213 | doi:10.1038/nrneph.2017.5
Nicotinamide adenine dinucleotide (NAD+) depletion contributes to the pathogenesis of cardiac and renal diseases. Here, the authors review the roles of NAD+ in the heart and kidney and discuss the mechanisms by which NAD+ supplementation might have therapeutic efficacy, with a focus on the role of mitochondrial sirtuins.
Abstract | Full Text | PDF

Crystal nephropathies: mechanisms of crystal-induced kidney injury
Shrikant R. Mulay & Hans-Joachim Anders
Published online: 20 February 2017
p226 | doi:10.1038/nrneph.2017.10
Crystals can trigger different types of renal injury according to their speed at which they form and their localization. Here, the authors discuss shared and specific mechanisms underlying crystal formation and renal injury, such as regulated cell death and inflammasome activation.
Abstract | Full Text | PDF

Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Lakhmir S. Chawla, Rinaldo Bellomo, Azra Bihorac, Stuart L. Goldstein, Edward D. Siew, Sean M. Bagshaw, David Bittleman, Dinna Cruz, Zoltan Endre, Robert L. Fitzgerald, Lui Forni, Sandra L. Kane-Gill, Eric Hoste, Jay Koyner, Kathleen D. Liu, Etienne Macedo, Ravindra Mehta, Patrick Murray, Mitra Nadim, Marlies Ostermann, Paul M. Palevsky, Neesh Pannu, Mitchell Rosner, Ron Wald, Alexander Zarbock, Claudio Ronco, John A. Kellum & on behalf of the Acute Disease Quality Initiative Workgroup 16.
Published online: 27 February 2017
p241 | doi:10.1038/nrneph.2017.2

Acute kidney injury (AKI) and chronic kidney disease are increasingly recognized as interconnected entities and the term acute kidney disease (AKD) has been proposed to define ongoing pathophysiologic processes following an episode of AKI. In this Consensus statement, the Acute Disease Quality Initiative 16 Workgroup propose definitions and staging criteria for AKD, and strategies for the management of affected patients. They also make recommendations for areas of future research with the aims of improving understanding of the underlying processes and improving outcomes.

Abstract | Full Text | PDF | Supplementary information
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