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woensdag 15 maart 2017

Nature Reviews Cardiology - Table of Contents alert Volume 14 Issue 4

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Nature Reviews Cardiology

Poster on effects of new antidiabetic drugs on cardiovascular health

This poster summarizes cardiovascular outcome trials of newly developed glucose-lowering agents. Some of these drugs have shown cardiovascular benefit that might have clinical importance in the management of type 2 diabetes. 

Available to download

Supported by an educational grant from Novo Nordisk
April 2017 Volume 14 Number 4Advertisement
Nature Reviews Cardiology cover
2015 2-year Impact Factor 10.533 Journal Metrics 2-year Median 6
In this issue
Research Highlights
News and Views
Consensus Statement

Also this month
 Featured article:
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure  Open
David A. Brown, Justin B. Perry, Mitchell E. Allen, Hani N. Sabbah, Brian L. Stauffer, Saame Raza Shaikh, John G. F. Cleland, Wilson S. Colucci, Javed Butler, Adriaan A. Voors, Stefan D. Anker, Bertram Pitt, Burkert Pieske, Gerasimos Filippatos, Stephen J. Greene & Mihai Gheorghiade

Key Advances in Medicine eBook from Nature Reviews - FREE to download! 

This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2016 and highlights the trends to watch out for in 2017, making it a must read eBook for anyone with an interest in medical science. 

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Comment: Cardiovascular disease prevention: lifestyle attenuation of genetic risk
Benoit J. Arsenault & Jean-Pierre Despres
Published online: 16 February 2017
p187 | doi:10.1038/nrcardio.2017.20

Both rare and common genetic variants predict the onset of cardiovascular disease (CVD), but recent studies have provided compelling evidence that individuals who harbour variants that elevate their risk of CVD can substantially lower this risk by controlling lifestyle-related risk factors, such as smoking, diet, and physical activity.
Full Text | PDF | Supplementary information


Anticoagulation therapy: Registries reveal real-world use of anticoagulant drugs in AF
Published online: 02 March 2017
p189 | doi:10.1038/nrcardio.2017.25


Stem cells: Allogenic mesenchymal stem cells for dilated cardiomyopathy
Published online: 16 February 2017
p190 | doi:10.1038/nrcardio.2017.21


Hypertension: The rise of the four-in-one pill?
Published online: 02 March 2017
p190 | doi:10.1038/nrcardio.2017.30


Risk factors: Aircraft noise impairs vascular function
Published online: 14 March 2017
p191 | doi:10.1038/nrcardio.2017.32



Metabolism: Calorie restriction for healthy ageing | Thrombosis: Rivaroxaban, a cost-effective alternative for SVT? | Valvular disease: DPP4 inhibitors to prevent aortic valve calcification

JOBS of the week
Assistant Professor of Medicine
Brigham and Women's Hospital - Harvard Medical School Teaching Hospital
Postdoctoral fellowships in genetic epidemiology of congenital heart disease
Stanford University School of Medicine (Pediatric Cardiology)
POSTDOC in Cardiopulmonary Molecular Biology
Hannover Medical School (MHH)
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2nd Congress of Cardiovascular Prevention in Pre-Elderly & Elderly Individuals (CPPEI 2017)
Vienna, Austria
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Hypertension: Controversies in blood-pressure goals among the elderly
Josep Redon
Published online: 14 March 2017
p193 | doi:10.1038/nrcardio.2017.29
The optimal blood-pressure (BP) goals for elderly patients remain inconclusive, despite the recent publication of meta-analyses comparing intensive BP control with standard BP control. In searching for therapeutic approaches in these patients, researchers should change the focus from optimal BP values to a more holistic, individual approach.
Full Text | PDF

Inflammation: Old, caffeinated, and healthy
Filip K. Swirski & Matthias Nahrendorf
Published online: 02 March 2017
p194 | doi:10.1038/nrcardio.2017.22
Inflammation is a recognized component of many diseases, including atherosclerosis and its complications. IL-1β is a crucial cytokine promoting the inflammatory cascade. In the February 2017 issue of Nature Medicine, Furman et al. show that metabolites can trigger inflammation via inflammasome-dependent IL-1β production in elderly individuals. Intriguingly, caffeine is protective by offsetting this activation.
Full Text | PDF

Collection: Cardiovascular disease in women

Differences exist in the prevalence of particular forms of cardiovascular disease between women and men. In this Collection from Nature Reviews Cardiology, we explore the sex-specific differences in the prevalence, diagnosis, and treatment of atrial fibrillation, acute coronary syndromes, microvascular dysfunction, ischaemic heart disease, and heart failure. 

Aetiology and management of hereditary aortopathy
Aline Verstraeten, Ilse Luyckx & Bart Loeys
Published online: 19 January 2017
p197 | doi:10.1038/nrcardio.2016.211
In this Review, the authors discuss the pathological mechanisms involved in thoracic aortic aneurysms (TAAs), including extracellular matrix homeostasis, transforming growth factor-β signalling, and vascular smooth muscle cell contractility. The understanding of TAA genetics might not only help to characterize the aetiology of more complex forms of this disease, but can also lead to the development of new therapeutic strategies and patient management.
Abstract | Full Text | PDF

Advanced imaging in valvular heart disease
Jeroen J. Bax & Victoria Delgado
Published online: 27 January 2017
p209 | doi:10.1038/nrcardio.2017.1
Innovations in noninvasive imaging have provided new insights in the pathophysiology and quantification of valvular heart disease. In this Review, Bax and Delgado discuss the novel imaging modalities used to assess the pathophysiology, dysfunction, and prognosis of aortic stenosis, mitral regurgitation, and aortic regurgitation.
Abstract | Full Text | PDF

Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors
Josef Finsterer, Claudia Stöllberger & Jeffrey A. Towbin
Published online: 12 January 2017
p224 | doi:10.1038/nrcardio.2016.207
Left ventricular hypertrabeculation or noncompaction is a myocardial abnormality frequently associated with monogenic disorders, particularly neuromuscular disorders, or with chromosomal defects. The pathogenesis of this cardiomyopathy remains unknown, and the diagnostic criteria, prognosis, and optimal treatment are under debate. In this Review, Finsterer et al. provide an update on the aetiology, pathophysiology, diagnosis, treatment, and prognosis of left ventricular hypertrabeculation.
Abstract | Full Text | PDF

Expert consensus document: Mitochondrial function as a therapeutic target in heart failure OPEN
David A. Brown et al.
Published online: 22 December 2016
p238 | doi:10.1038/nrcardio.2016.203

The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.
Abstract | Full Text | PDF
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Nature Reviews Cardiology was previously published as Nature Clinical Practice Cardiovascular Medicine.

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