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maandag 27 februari 2017

The Lancet: [Comment] Laminar airflow and surgical site infections: the evidence is blowing in the wind

[Comment] Laminar airflow and surgical site infections: the evidence is blowing in the wind
More than a million joint arthroplasties are done each year; with an ageing population, numbers of arthroplasties might grow two to six times by 2030.1 A major concern is the risk of operating room-acquired prosthetic joint infections, which cause substantial morbidity, prolonged treatment in hospital, repeat surgeries, prolonged antibiotic use, and patient, family, and societal stresses—all at great cost.2
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[Review] Helminths in organ transplantation
With transplantation becoming an increasingly routine form of treatment for diverse populations, and with international travel becoming ever more accessible and affordable, the danger of transplantation-mediated helminth infections, exacerbated by coincident immunosuppression, must be considered. In this Review, we attempt to catalogue all clinically-relevant helminthiases that have been reported to coincide with transplantation, whether by transplantation-mediated transmission, reactivation of latent infections in an immunosuppressed context, or possible de-novo infection during the immunosuppressed peritransplant period.
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[Articles] Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial
This tetravalent E coli bioconjugate vaccine candidate was well tolerated and elicited functional antibody responses against all vaccine serotypes. Phase 2 studies have been initiated to confirm these findings.
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[Comment] A new way to prevent urinary tract infections?
About 50–60% of women will get at least one urinary tract infection in their lifetime.1,2 After an uncomplicated UTI—ie, an infection not associated with structural or functional disorders of the urinary tract—around 25% of women experience a recurrent infection within 6–12 months, and around 5% have several episodes within a year.3 Mostly young women are affected by recurrent UTIs, but postmenopausal women are also often affected.4 About 75–85% of uncomplicated UTIs are caused by Escherichia coli.
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[Articles] Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus
This new highly specific and sensitive assay showed asymptomatic infection with Ebola virus was uncommon despite high exposure. The low prevalence suggests asymptomatic infection contributes little to herd immunity in Ebola, and even if infectious, would account for few transmissions.
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