We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

donderdag 9 februari 2017

The Lancet: [Comment] C/Can 2025: City Cancer Challenge, a new initiative to improve cancer care in cities

[Comment] C/Can 2025: City Cancer Challenge, a new initiative to improve cancer care in cities
Cancer and other non-communicable diseases (NCDs) enjoy an unprecedented global profile, yet of the 4 billion people living in cities today, few of them have access to high-quality cancer treatment outside of high-income countries.
Read more

[Comment] Intermittent vismodegib dosing to treat multiple basal-cell carcinomas
Many basal-cell carcinomas can be treated effectively by uncomplicated surgical excision.1 Longstanding tumours, which are often neglected or maltreated, might become inoperable. Targeted treatment with Smoothened homologue (SMO) inhibitors, such as vismodegib and sonidegib, has shown part or complete clearance.2,3 In patients with advanced basal-cell carcinoma, however, 1 year of vismodegib treatment was associated with complete response in only 34%, and resistance seemed to be a serious problem.
Read more

[Articles] Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE): a randomised, regimen-controlled, double-blind, phase 2 trial
Both intermittent dosing schedules of vismodegib seemed to show good activity in long-term regimens in patients with multiple basal-cell carcinomas. Further study is warranted.
Read more

[Articles] Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial
Delaying surgery after short-course radiotherapy gives similar oncological results compared with short-course radiotherapy with immediate surgery. Long-course radiotherapy with delay is similar to both short-course radiotherapy regimens, but prolongs the treatment time substantially. Although radiation-induced toxicity was seen after short-course radiotherapy with delay, postoperative complications were significantly reduced compared with short-course radiotherapy. Based on these findings, we suggest that short-course radiotherapy with delay to surgery is a useful alternative to conventional short-course radiotherapy with immediate surgery.
Read more

[News] Bicalutamide with radiotherapy for prostate cancer
Patients with prostate cancer who received 2 years of the anti-androgen therapy bicalutamide in addition to salvage radiotherapy had significantly longer overall survival compared with those who received placebo, according to a double-blind, randomised phase 3 trial.
Read more