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Scientific Reports Health Sciences Table of Contents e-alert: 07 February 2017

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  07 February 2017   
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Health Sciences

Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice


Zhenhua Li, Yingzhan Zhang, Bin Liu et al.


Prostacyclin, also termed as prostaglandin I2 (PGI2), evokes contraction in vessels with limited expression of the prostacyclin receptor. Although the thromboxane-prostanoid …


Agreement of patient-measured intraocular pressure using rebound tonometry with Goldmann applanation tonometry (GAT) in glaucoma patients


Shaoying Tan, Marco Yu, Nafees Baig et al.


This study aims to determine the agreement of patient-measured intraocular pressure (IOP) using rebound tonometry with ophthalmologist-measured IOP using Goldmann applanation …


Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS


Barış Genç, Javier H. Jara, Amiko K. B. Lagrimas et al.


Apical dendrites of Betz cells are important sites for the integration of cortical input, however their health has not been fully assessed in ALS patients. We investigated the …


Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis


Averi L. Gibson, Carrie K. Hui Mingalone, Andrea T. Foote et al.


Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known. In this study, we …


Risk profile and HIV testing outcomes of women undergoing community-based testing in San Diego 2008–2014


Susannah K. Graves, Susan J. Little, Martin Hoenigl


Women comprised 19% of new HIV diagnoses in the United States in 2014, with significant racial and ethnic disparities in infection rates. This cross-sectional analysis of women …


Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma


Xiao Gu, Zhongyan Hua, Yudi Dong et al.


Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth. However, studies indicate that in addition to the ability to inhibit Akt, …


Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation


Vilfredo De Pascalis, Francesca Fracasso, Philip J. Corr


An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the …


Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling


Xiaojv Xiong, Yu Liu, Yang Mei et al.


Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. …


Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis


Yanqiong Zhang, Chen Yan, Yuting Li et al.


To clarify unknown rationalities of herbaceous compatibility of Euphorbia Pekinensis (DJ) and Glycyrrhiza glabra (GC) acting on hepatocellular carcinoma (HCC) ascites, peritoneum …


Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes


Hongqin Xu, Fan Wang, Henry R. Kranzler et al.


Altered DNA methylation in addiction-related genes may modify the susceptibility to alcohol or drug dependence (AD or ND). We profiled peripheral blood DNA methylation levels of …


The Demographic Features, Clinicopathological Characteristics and Cancer-specific Outcomes for Patients with Microinvasive Breast Cancer: A SEER Database Analysis


Wenna Wang, Wenjie Zhu, Feng Du et al.


To investigate the clinicopathological characteristics and survival outcomes of microinvasive breast cancer, we conducted an observational study of female diagnosed with DCIS or …


Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo


Tao Huang, Yubo Xiao, Lin Yi et al.


Colorectal cancer is one of the most common causes of cancer-related death in humans. Coptisine (COP) is a natural alkaloid from Coptidis Rhizoma with unclear antitumor …


Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia


Yasser A. Elnakady, Ahmed I. Rushdi, Raimo Franke et al.


Propolis has been used to treat several diseases since ancient times, and is an important source of bioactive natural compounds and drug derivatives. These properties have kept …


Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease


Yoko Ogawa, Hua He, Shin Mukai et al.


Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is …


β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications


Bo Gyung Kim, Jin Young Kim, JinSei Jung et al.


The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. …


Serum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chinese


Jing Wang, Yaru Li, Xu Han et al.


Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly …


Acellular Urethra Bioscaffold: Decellularization of Whole Urethras for Tissue Engineering Applications


Irina N. Simões, Paulo Vale, Shay Soker et al.


Patients with stress urinary incontinence mainly suffer from malfunction of the urethra closure mechanism. We established the decellularization of porcine urethras to produce …


Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol


Yichen Zhu, Toshio Takayama, Bowen Wang et al.


To date, there is no periadventitial drug delivery method available in the clinic to prevent restenotic failure of open vascular reconstructions. Resveratrol is a promising …


Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response


Xinru Jiang, Yuli Wang, Yifei Qin et al.


A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G+) bacteria, most commonly staphylococci, are thought to …


A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice


Joen-Rong Sheu, Zhih-Cherng Chen, Thanasekaran Jayakumar et al.


Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a …


Alteration of Multiple Leukocyte Gene Expression Networks is Linked with Magnetic Resonance Markers of Prognosis After Acute ST-Elevation Myocardial Infarction


A. Teren, H. Kirsten, F. Beutner et al.


Prognostic relevant pathways of leukocyte involvement in human myocardial ischemic-reperfusion injury are largely unknown. We enrolled 136 patients with ST-elevation myocardial …


Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression


Chai K. Lim, Ayse Bilgin, David B. Lovejoy et al.


Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain …


Physical activity is low in obese New Zealand children and adolescents


Yvonne C. Anderson, Lisa E. Wynter, Cameron C. Grant et al.


We aimed to describe physical activity and sedentary behaviour of obese children and adolescents in Taranaki, New Zealand, and to determine how these differ in Māori (indigenous) …


Unravelling the genetic basis of simplex Retinitis Pigmentosa cases


Nereida Bravo-Gil, María González-del Pozo, Marta Martín-Sánchez et al.


Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and …


Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors


Nuria Perretta-Tejedor, Javier Fernández-Mateos, Luis García-Ortiz et al.


Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members …


Platelets protect lung from injury induced by systemic inflammatory response


Shuhua Luo, Yabo Wang, Qi An et al.


Systemic inflammatory responses can severely injure lungs, prompting efforts to explore how to attenuate such injury. Here we explored whether platelets can help attenuate lung …


Photothermal therapeutic application of gold nanorods-porphyrin-trastuzumab complexes in HER2-positive breast cancer


Xinmei Kang, Ximing Guo, Weiwei An et al.


Gold nanorods are effective photothermal agents in diagnosis and treatment of cancer due to their specific near-infrared laser absorption. However, tumor photothermal therapy by …


Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice


Tuong Thi Van Thuy, Le Thi Thanh Thuy, Katsutoshi Yoshizato et al.


This study clarified the role of Cygb, the fourth globin in mammals originally discovered in rat hepatic stellate cells (HSCs), in cholestatic liver disease. Bile duct ligation …


Preoperative adjuvant transarterial chemoembolization cannot improve the long term outcome of radical therapies for hepatocellular carcinoma


Lei Jianyong, Zhong Jinjing, Yan Lunan et al.


Combinations of transarterial chemoembolization (TACE) and radical therapies (pretransplantation, resection and radiofrequency ablation) for hepatocellular carcinoma (HCC) have …


Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice


Juliette M. K. M. Delhove, Suzanne M. K. Buckley, Dany P. Perocheau et al.


Molecular mechanisms regulating liver repair following cholestatic injury remain largely unknown. We have combined a mouse model of acute cholestatic liver injury, partial bile …


Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells


Izabela Nita, Katrin Hostettler, Luca Tamo et al.


Idiopathic Pulmonary Fibrosis (IPF) is a progressive, irreversible lung disease with complex pathophysiology. Evidence of endoplasmic reticulum (ER) stress has been reported in …


Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain


Tony W. Wilson, Amy L. Proskovec, Elizabeth Heinrichs-Graham et al.


Impairments in working memory are among the most prevalent features of HIV-associated neurocognitive disorders (HAND), yet their origins are unknown, with some studies arguing …


Subregional structural and connectivity damage in the visual cortex in neuromyelitis optica


Huanhuan Cai, Jiajia Zhu, Ningnannan Zhang et al.


Patients with neuromyelitis optica (NMO) have shown structural and functional impairments in the visual cortex. We aimed to characterize subregional grey matter volume (GMV) and …


Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia


Karen Grütz, Philip Seibler, Anne Weissbach et al.


In neuropathology research, induced pluripotent stem cell (iPSC)-derived neurons are considered a tool closely resembling the patient brain. Albeit in respect to epigenetics, …


New perspectives on corpora amylacea in the human brain


Elisabet Augé, Itsaso Cabezón, Carme Pelegrí et al.


Corpora amylacea are structures of unknown origin and function that appear with age in human brains and are profuse in selected brain areas in several neurodegenerative …


The citrus flavanone naringenin impairs dengue virus replication in human cells


Sandra Frabasile, Andrea Cristine Koishi, Diogo Kuczera et al.


Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a …


Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites


José Luis Miguel-Carrasco, Javier Beaumont, Gorka San José et al.


Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The …


A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs


Irina Neganova, Valeria Chichagova, Lyle Armstrong et al.


Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) holds enormous promise for regenerative medicine. Reprogramming is a stepwise process with well-defined …


Subjective craving and event-related brain response to olfactory and visual chocolate cues in binge-eating and healthy individuals


I. Wolz, A. Sauvaget, R. Granero et al.


High-sugar/high-fat foods are related to binge-eating behaviour and especially people with low inhibitory control may encounter elevated difficulties to resist their intake. …


Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox


Qianying Liu, Zhixin Lei, Anxiong Huang et al.


Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O …


Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice


Bo Hang, Antoine M. Snijders, Yurong Huang et al.


Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on …


Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis


Jörg Friess, Michael Hecker, Luisa Roch et al.


Multiple sclerosis is a demyelinating disease affecting the central nervous system. T cells are known to contribute to this immune-mediated condition. Fingolimod modulates …


Understanding cancer complexome using networks, spectral graph theory and multilayer framework


Aparna Rai, Priodyuti Pradhan, Jyothi Nagraj et al.


Cancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms and response to therapy. The combined framework of …


Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species


Florencia González-Lizárraga, Sergio B. Socías, César L. Ávila et al.


Synucleinophaties are progressive neurodegenerative disorders with no cure to date. An attractive strategy to tackle this problem is repurposing already tested safe drugs against …


IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry


María Carolina Sanabria-Salas, Gustavo Hernández-Suárez, Adriana Umaña-Pérez et al.


Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association …


Retinopathy Signs Improved Prediction and Reclassification of Cardiovascular Disease Risk in Diabetes: A prospective cohort study


Henrietta Ho, Carol Y. Cheung, Charumathi Sabanayagam et al.


CVD risk prediction in diabetics is imperfect, as risk models are derived mainly from the general population. We investigate whether the addition of retinopathy and retinal …


Association of Genomic Instability with HbA1c levels and Medication in Diabetic Patients


Annemarie Grindel, Helmut Brath, Armen Nersesyan et al.


Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed …


Levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffold for the treatment of chronic osteomyelitis with bone defects


Qi Wang, Cheng Chen, Wen Liu et al.


Chronic osteomyelitis is a prolonged persistent disease accompanied by bone destruction and sequestrum formation, it is very difficult to treat. Antibiotic loaded polymethyl …


Tubular B7-1 expression parallels proteinuria levels, but not clinical outcomes in adult minimal change disease patients


Sung Woo Lee, Seon Ha Baek, Jin Ho Paik et al.


B7-1 is thought to play a pathogenic role in minimal-change disease (MCD). Recently, however, doubts have arisen regarding the role of B7-1 expression in MCD. Therefore, we aimed …


TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors


Michiko Matsuse, Tomonori Yabuta, Vladimir Saenko et al.


Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular …


Significant survival benefit of adjuvant chemotherapy after concurrent chemoradiotherapy in locally advanced high-risk nasopharyngeal carcinoma


Zhong-Guo Liang, Xiao-Qian Chen, Guo-Xiang Lin et al.


The present study aimed to define high-risk patients who may benefit from additional adjuvant chemotherapy (AC) after concurrent chemotherapy in combination with …


Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls


Marc Zanello, Fanny Poulon, Johan Pallud et al.


Delineating tumor margins as accurately as possible is of primordial importance in surgical oncology: extent of resection is associated with survival but respect of healthy …


High density lipoprotein (HDL) particles from end-stage renal disease patients are defective in promoting reverse cholesterol transport


Josephine L.C. Anderson, Thomas Gautier, Niels Nijstad et al.


Atherosclerotic cardiovascular disease (CVD) represents the largest cause of mortality in end-stage renal disease (ESRD). CVD in ESRD is not explained by classical CVD risk …


Gestational Weight Gain and Fetal-Maternal Adiponectin, Leptin, and CRP: results of two birth cohorts studies


Chad A. Logan, Rebecca Bornemann, Wolfgang Koenig et al.


Gestational weight gain (GWG) is an important modifiable factor known to influence fetal outcomes including birth weight and adiposity. Unlike behaviors such as smoking and …


Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria


Zahraa Mohammed-Ali, Chao Lu, Mandeep K. Marway et al.


Endoplasmic reticulum (ER) stress is implicated in chronic kidney disease (CKD) development in patients and in animal models. Here we show that ER stress inhibition through …


Repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells in a rat model


Xiao-Rui Jiang, Hui-Ying Yang, Xin-Xin Zhang et al.


This study aims to investigate the repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells (BMSCs) in a …


Alexithymia and personality traits of patients with inflammatory bowel disease


D. La Barbera, B. Bonanno, M. V. Rumeo et al.


Psychological factors, specific lifestyles and environmental stressors may influence etiopathogenesis and evolution of chronic diseases. We investigate the association between …


Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways


Agnieszka P. Grzegorzewska, Francesca Seta, Rong Han et al.


Pulmonary arterial hypertension (PAH) is a fatal condition for which there is no cure. Dimethyl Fumarate (DMF) is an FDA approved anti-oxidative and anti-inflammatory agent with …


Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells


Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama et al.


Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11


Photodynamic therapy monitoring with optical coherence angiography


M. A. Sirotkina, L. A. Matveev, M. V. Shirmanova et al.


Photodynamic therapy (PDT) is a promising modern approach for cancer therapy with low normal tissue toxicity. This study was focused on a vascular-targeting Chlorine E6 mediated …


Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans


H. Napierala, K.-H. Hillebrandt, N. Haep et al.


Decellularization of pancreata and repopulation of these non-immunogenic matrices with islets and endothelial cells could provide transplantable, endocrine Neo- Pancreata. In …


Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis


Johanna Teräsjärvi, Antti Hakanen, Matti Korppi et al.


Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different …


The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1


Keith Dadson, Ludger Hauck, Zhenyue Hao et al.


Cardiac homeostasis requires proper control of protein turnover. Protein degradation is principally controlled by the Ubiquitin-Proteasome System. Mule is an E3 ubiquitin ligase …


Alterations in the carnitine cycle in a mouse model of Rett syndrome


Sabrina Mucerino, Anna Di Salle, Nicola Alessio et al.


Rett syndrome (RTT) is a neurodevelopmental disease that leads to intellectual deficit, motor disability, epilepsy and increased risk of sudden death. Although in up to 95% of …


P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus


Rafael González-Tajuelo, Javier Silván, Alicia Pérez-Frías et al.


Mice deficient in P-Selectin presented altered immunity/tolerance balance. We have observed that the absence of P-Selectin promotes splenomegaly with reduced naïve T cell …


Rapid cell separation with minimal manipulation for autologous cell therapies


Alban J. Smith, Richard D. O’Rorke, Akshay Kale et al.


The ability to isolate specific, viable cell populations from mixed ensembles with minimal manipulation and within intra-operative time would provide significant advantages for …


Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain


Chan Zhang, Rong-Xiang Chen, Yu Zhang et al.


The ventrobasal (VB) thalamus is innervated by GABAergic afferents from the thalamic reticular nucleus (TRN) and participates in nociception. But how the TRN-VB pathway regulates …


Cellular prion protein is present in mitochondria of healthy mice


Robert Faris, Roger A. Moore, Anne Ward et al.


Cellular prion protein (PrPC) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrPC misfolds to a …


Early life antibiotic exposure affects pancreatic islet development and metabolic regulation


Jiaying Li, Kaiyuan Yang, Tingting Ju et al.


Childhood antibiotic exposure has been recently linked with increased risk of metabolic disease later in life. A better understanding of this association would potentially …


Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation


Richard L. Lin, Gwenaëlle Douaud, Nicola Filippini et al.


An increased understanding of the relationship between structural connections and functional and behavioral outcomes is an essential but under-explored topic in neuroscience. …


Serum prealbumin and its changes over time are associated with mortality in acute kidney injury


Wenji Wang, Yu Pan, Xiao Tang et al.


Serum prealbumin is a clinically relevant indicator of nutritional status and inflammation in patients with acute kidney injury (AKI). This study aimed to determine whether serum …


Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid


Xing Li, Wen Sun, Jinbo Li et al.


Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of osteoporotic fracture. However, the effects of CLP on bone metabolism are unknown. Here, …


Computational imaging reveals shape differences between normal and malignant prostates on MRI


Mirabela Rusu, Andrei S. Purysko, Sadhna Verma et al.


We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer …


Improving the diagnostic accuracy of acute myocardial infarction with the use of high-sensitive cardiac troponin T in different chronic kidney disease stages


Hongliu Yang, Jing Liu, Han Luo et al.


High-sensitive cardiac troponin T (hs-TnT) is a critical biomarker in diagnosis of acute myocardial infarction (AMI). However, CKD individuals usually have elevated hs-TnT even …


High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder


Galina Schmunk, Rachel L. Nguyen, David L. Ferguson et al.


Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders without any defined uniting pathophysiology. Ca2+ signaling is emerging as a potential …


Whole Genome Sequencing Identifies Novel Compound Heterozygous Lysosomal Trafficking Regulator Gene Mutations Associated with Autosomal Recessive Chediak-Higashi Syndrome


Yaqiong Jin, Li Zhang, Senfen Wang et al.


Chediak–Higashi syndrome (CHS) is a rare autosomal recessive disease characterized by varying degrees of oculocutaneous albinism, recurrent infections, and a mild bleeding …


High prevalence of toxigenic Clostridium difficile in public space lawns in Western Australia


Peter Moono, Su Chen Lim, Thomas V. Riley


Clostridium difficile is a well-established hospital pathogen. Recently, it has been detected increasingly in patients without hospital contact. Given this rise in community …


Impact of the use of an endorectal coil for 3 T prostate MRI on image quality and cancer detection rate


Josephin Gawlitza, Martin Reiss-Zimmermann, Gregor Thörmer et al.


This work aims to assess the impact of an additional endorectal coil on image quality and cancer detection rate within the same patients. At a single academic medical center, …


Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes


Anna Melissa Schlitter, Angela Segler, Katja Steiger et al.


Pancreatic ductal adenocarcinoma (PDAC) has generally a poor prognosis, but recent data suggest that there are molecular subtypes differing in clinical outcome. This study …


Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator


Mamiko Asano, Minoru Sakaguchi, Satoshi Tanaka et al.


We investigated the effects of microwave irradiation under normothermic conditions on cultured cells. For this study, we developed an irradiation system constituted with …


Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway


Jing Ke, Ye Liu, Jin Yang et al.


Metformin or glucagon-like peptide-1 (GLP-1) analogue liraglutide has cardiovascular benefits. However, it is not clear whether their combined treatment have additive or …


TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice


Shih-Ping Dai, Ya-Han Huang, Chung-Jen Chang et al.


Chronic pain, resulting from injury, arthritis, and cancer, is often accompanied by inflammation. High concentrations of protons found in inflamed tissues results in tissue …


ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis


Lei-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang et al.


ZP3 is a principal component of the zona pellucida (ZP) of mammalian oocytes and is essential for normal fertility, and knockout of ZP3 causes complete infertility. ZP3 promotes …


Improving polygenic risk prediction from summary statistics by an empirical Bayes approach


Hon-Cheong So, Pak C. Sham


Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives …


Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice


Zhong-Tang Li, Li-Mei Wang, Li-Rong Yi et al.


α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to …


Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication


Kjersti M. Aagaard, Anismrita Lahon, Melissa A. Suter et al.


Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic …


Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process


Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung et al.


Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in …


Vitamin D Receptor Activator Use and Cause-specific Death among dialysis Patients: a Nationwide Cohort Study using Coarsened Exact Matching


Yoshitsugu Obi, Takayuki Hamano, Atsushi Wada et al.


Vitamin D receptor activators (VDRA) may exert pleiotropic effects on cardiovascular disease, malignancy, and infections among dialysis patients, but recent studies have mainly …


BMP2-coprecipitated calcium phosphate granules enhance osteoinductivity of deproteinized bovine bone, and bone formation during critical-sized bone defect healing


Tie Liu, Yuanna Zheng, Gang Wu et al.


Most materials used clinically for filling critical-sized bone defects (CSBD), such as deproteinized bovine bone (DBB), lack osteoinductivity so that their therapeutic effects …


Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model


Reas S. Khan, Kimberly Dine, Bailey Bauman et al.


The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental …


Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice


Hideyuki Shirasawa, Noboru Matsumura, Masayuki Shimoda et al.


Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle …


Evaluation of the Bone-ligament and tendon insertions based on Raman spectrum and its PCA and CLS analysis


Yang Wu, Yu Dong, Jia Jiang et al.


Injuries to the Anterior Cruciate Ligament (ACL) and Rotator Cuff Tendon (RCT) are common in physically active and elderly individuals. The development of an artificial …


Analysis of the Prevalence and Factors Associated with Nocturia in Adult Korean Men


So Young Kim, Woojin Bang, Min-Su Kim et al.


This study investigated the prevalence of and factors associated with nocturia in Korean men. A total of 92,626 participants aged between 19 and 103 years from the 2011 Korean …


Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome


Edward Oh, Richie Jeremian, Gabriel Oh et al.


Transcriptional variation in histologically- and genetically- identical cells is a widespread phenomenon in tissues, yet the processes conferring this heterogeneity are not well …


The value of resting-state functional MRI in subacute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced perfusion MRI


Ling Ni, Jingwei Li, Weiping Li et al.


To evaluate the potential clinical value of the time-shift analysis (TSA) approach for resting-state fMRI (rs-fMRI) blood oxygenation level-dependent (BOLD) data in detecting …


Feasibility of alternating induction and maintenance chemotherapy in pancreatic cancer


Alexander Hann, Wolfram Bohle, Jan Egger et al.


Chemotherapy regimens for pancreatic ductal adenocarcinoma (PDAC) have changed since the introduction of FOLFIRINOX. Due to toxicity, dosage and number of applied cycles are …


Prevalence of kidney stones in mainland China: A systematic review


Wenying Wang, Jingyuan Fan, Guifeng Huang et al.


The data on the prevalence of kidney stones in mainland China are still lacking. We performed the present meta-analysis to assess the stone prevalence in mainland China from 1990 …


Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation


Wei Wang, Qianqian Zhuang, Kunqian Ji et al.


Researchers in the field of mitochondrial biology are increasingly unveiling of the complex mechanisms between mitochondrial dysfunction and noncoding RNAs (ncRNAs). However, …


Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation


Minho Lee, Na Young Lee, Kyung-Sook Chung et al.


Roxatidine is an active metabolite of roxatidine acetate hydrochloride which is a histamine H2-receptor antagonist that is used to treat gastric and duodenal ulcers. In this …


Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis


Anu Pasanen, Minna K. Karjalainen, Louis Bont et al.


Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic …


Comparative analysis of image classification methods for automatic diagnosis of ophthalmic images


Liming Wang, Kai Zhang, Xiyang Liu et al.


There are many image classification methods, but it remains unclear which methods are most helpful for analyzing and intelligently identifying ophthalmic images. We select …


Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder


Yi-Ling Chien, Shao-Wei Wu, Chih-Pang Chu et al.


Sensory disturbance is associated with socio-emotional problems in individuals with autism spectrum disorder (ASD). Most studies assess sensory symptoms by self-reports, which …


Long Blood Residence and Large Tumor Uptake of Ruthenium Sulfide Nanoclusters for Highly Efficient Cancer Photothermal Therapy


Zhuoxuan Lu, Feng-ying Huang, Rong Cao et al.


Transition metal sulfide (TMS) holds great potential in cancer photothermal therapy (PTT) because of the high absorbance in the near-infrared (NIR) region. The short blood …


Germline large genomic alterations on 7q in patients with multiple primary cancers


R. A. R. Villacis, T. R. Basso, L. M. Canto et al.


Patients with multiple primary cancers (MPCs) are suspected to have a hereditary cancer syndrome. However, only a small proportion may be explained by mutations in …


Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma


Wenjie Zhang, Xiaochen Wang, Ruyi Huang et al.


Marital status have been found as an independent prognostic factor for survival and spousal support could provide a survival advantage in various cancer types. However, the …


The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF


Michael Schuliga, Jade Jaffar, Trudi Harris et al.


The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin has potent fibrogenic actions involving protease …


Cortisol Awakening Response and Acute Stress Reactivity in First Nations People


Maximus Berger, Anthony Leicht, Angela Slatcher et al.


First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network …


Development of polymer based cryogel matrix for transportation and storage of mammalian cells


Jyoti Kumari, Ashok Kumar


We studied the potential of polymeric cryogel matrices such as 2-hydroxyethyl methacrylate (HEMA)-agarose (HA) and gelatin matrix as a transporting and storage material for …


A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria


Sandrine Marquet, Ianina Conte, Belco Poudiougou et al.


Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. This encephalopathy is characterized by coma and is thought to result from mechanical …


Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells


Diego Martin-Sanchez, Angel Gallegos-Villalobos, Miguel Fontecha-Barriuso et al.


Iron deficiency has been associated with kidney injury. Deferasirox is an oral iron chelator used to treat blood transfusion-related iron overload. Nephrotoxicity is the most …


The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity


Hien Anh Nguyen, Donald L. Durden, Arnon Lavie


Many side effects of current FDA-approved L-asparaginases have been related to their secondary L-glutaminase activity. The Wolinella succinogenes L-asparaginase (WoA) has been …

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