We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

woensdag 22 februari 2017

Nature Reviews Rheumatology - Table of Contents alert Volume 13 Issue 3

If you are unable to see the message below, click here to view.

Nature Reviews Rheumatology

Key Advances in Medicine eBook from Nature Reviews - FREE to download! 

This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2016 and highlights the trends to watch out for in 2017, making it a must read eBook for anyone with an interest in medical science. 

Download for free
March 2017 Volume 13 Number 3
Nature Reviews Rheumatology cover
2015 2-year Impact Factor 10.531 Journal Metrics 2-year Median 7
In this issue
Research Highlights
News and Views

Also this month
 Featured article:
Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care
Erica F. Lawson & Elizabeth D. Mellins

Recommend to library

Vasculitis syndromes: Loss of immunoinhibitory checkpoint implicated in GCA
Published online: 09 February 2017
p129 | doi:10.1038/nrrheum.2017.20


Osteoarthritis: UCMA links cartilage and bone in OA
Published online: 09 February 2017
p130 | doi:10.1038/nrrheum.2017.9


Systemic lupus erythematosus: New pathway blocks disease in lupus-prone mice
Published online: 19 January 2017
p131 | doi:10.1038/nrrheum.2017.2


Inflammatory myopathies: Genetic associations with IBM
Published online: 09 February 2017
p131 | doi:10.1038/nrrheum.2017.8


Rheumatoid arthritis: Defective IL-10-producing Breg cells
Published online: 02 February 2017
p132 | doi:10.1038/nrrheum.2017.10


Rheumatoid arthritis: Nicotine exacerbates arthritis
Published online: 19 January 2017
p132 | doi:10.1038/nrrheum.2017.3



Bone: miR-106b promotes osteoporosis in mice | Therapy: Retreatment with rituximab is beneficial in RA | Rheumatoid arthritis: S100A9 does not predict response to etanercept | Undifferentiated arthritis: Features of UA that develops into RA revealed

Nature Reviews Rheumatology
JOBS of the week
Scientist in Retina and CNS Degenerative Disease
University Health Network (Toronto)
More Science jobs from
Nature Reviews Rheumatology
Pain Therapeutics
More science events from
Rheumatoid arthritis: TAK-ing the road to suppress inflammation in synovial fibroblasts
Mojca Frank-Bertoncelj & Steffen Gay
Published online: 12 January 2017
p133 | doi:10.1038/nrrheum.2016.220
Positioned at the crossroads of TNF, IL-1 and Toll-like receptor signalling cascades and cytokine-driven chromatin remodelling, TAK1 is emerging as a new therapeutic target in rheumatoid arthritis.
Full Text | PDF

Connective tissue disease: Reflections on the EULAR recommendations for the treatment of systemic sclerosis
Janet E. Pope
Published online: 05 January 2017
p134 | doi:10.1038/nrrheum.2016.212
The treatment of systemic sclerosis (SSc) is complex as multiple organs are frequently involved and treatment is either for overall disease modification or is organ specific. EULAR has updated its treatment recommendations for SSc, reflecting data from some new trials. However, some features of SSc are not included.
Full Text | PDF | Supplementary information

Therapy: Cardiovascular safety of celecoxib, naproxen and ibuprofen
Michael T. Nurmohamed
Published online: 27 January 2017
p136 | doi:10.1038/nrrheum.2017.4
The PRECISION trial demonstrates that celecoxib is noninferior to ibuprofen and naproxen in regard to cardiovascular safety. Do these findings mark the end of the debate on this issue, or do aspects of the trial mean the implications for clinical practice are not clear-cut?
Full Text | PDF

Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care
Erica F. Lawson & Elizabeth D. Mellins
Published online: 09 February 2017
p138 | doi:10.1038/nrrheum.2017.16
New guidelines from EULAR and the Paediatric Rheumatology European Society recommend a set of quality standards for the care of young adults with childhood-onset rheumatic diseases during their transfer from paediatric to adult rheumatology care providers. Can the application of these guidelines prevent patients from getting lost in the system?
Full Text | PDF

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases
Michele Bombardieri, Myles Lewis & Costantino Pitzalis
Published online: 09 February 2017
p141 | doi:10.1038/nrrheum.2016.217
Ectopic lymphoid structures have been identified in the target organs of a subset of patients with rheumatic autoimmune diseases. This Review describes these structures and summarizes our current understanding of how they form, function and contribute to autoimmunity.
Abstract | Full Text | PDF

The changing role of TGFβ in healthy, ageing and osteoarthritic joints
Peter M. van der Kraan
Published online: 02 February 2017
p155 | doi:10.1038/nrrheum.2016.219
Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease. In this Review, the changing role of TGFβ in normal joint homeostasis, ageing and osteoarthritis is discussed.
Abstract | Full Text | PDF

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases
Medya M. Shikhagaie, Kristine Germar, Suzanne M. Bal, Xavier Romero Ros & Hergen Spits
Published online: 02 February 2017
p164 | doi:10.1038/nrrheum.2016.218
Innate lymphoid cells are important players in the innate immune response, and might also contribute to inflammatory diseases. This Review discusses what is known about these cells and how they might be targeted in future therapies for these diseases.
Abstract | Full Text | PDF

Mixing omics: combining genetics and metabolomics to study rheumatic diseases
Cristina Menni, Jonas Zierer, Ana M. Valdes & Tim D. Spector
Published online: 02 February 2017
p174 | doi:10.1038/nrrheum.2017.5
Metabolomics and genomics approaches have produced huge amounts of data from patient samples, creating many research opportunities. In this Review, the authors discuss how these datasets can be brought together to enrich our knowledge of rheumatic diseases.
Abstract | Full Text | PDF | Supplementary information

Cartilage-targeting drug delivery: can electrostatic interactions help?
Ambika G. Bajpayee & Alan J. Grodzinsky
Published online: 09 February 2017
p183 | doi:10.1038/nrrheum.2016.210
Current osteoarthritis therapies cannot sufficiently target cartilage and guarantee a biological response owing to limitations in the delivery methods. This Perspectives article discusses how electrostatic interactions can be utilized to increase drug penetration and retention in cartilage to provide sustained intra-tissue delivery.
Abstract | Full Text | PDF

Corrigendum: Autophagy: controlling cell fate in rheumatic diseases
Jason S. Rockel & Mohit Kapoor
Published online: 09 February 2017
p193 | doi:10.1038/nrrheum.2017.17

Full Text | PDF
Erratum: Insight into rheumatological cause and effect through the use of Mendelian randomization
Philip C. Robinson, Hyon K. Choi, Ron Do & Tony R. Merriman
Published online: 22 February 2017
p193 | doi:10.1038/nrrheum.2017.18

Full Text | PDF
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events
Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

nature publishing group