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vrijdag 24 februari 2017

Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 14 Issue 3

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Nature Reviews Gastroenterology & Hepatology

Nature Outlook: Inflammatory Bowel Disease (IBD) 

For certain infections, faecal transplants have resulted in remarkable recoveries. Will the same ever be true for people with IBD? It's a condition on the rise in Asia, but why? Follow those trying to find out, and learn how our environments influence IBD in this Outlook. 

Access the Outlook

Produced with support from 
Salix Pharmaceuticals
March 2017 Volume 14 Number 3Advertisement
Nature Reviews Gastroenterology & Hepatology cover
2015 2-year Impact Factor 14.435 Journal Metrics 2-year Median 8
In this issue
Research Highlights
News and Views

Also this month
 Featured article:
Autophagy in the liver: functions in health and disease
Takashi Ueno & Masaaki Komatsu

Key Advances in Medicine eBook from Nature Reviews - FREE to download! 

This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2016 and highlights the trends to watch out for in 2017, making it a must read eBook for anyone with an interest in medical science. 

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Recommend to library
St. Vincent Healthcare seeks a gastroenterologist with a passion for interventional procedures to join three physicians and two midlevels in a turnkey practice integrated with hospital services. We invite applications from BE or BC physicians with an interest in full or part time positions who value work life balance and being part of a collaborative and collegial team.
Comment: Primetime for e-health in IBD?
Peter Bossuyt, Lieven Pouillon & Laurent Peyrin-Biroulet
Published online: 25 January 2017
p133 | doi:10.1038/nrgastro.2017.11

The treatment of IBD is currently suboptimal. Continuous monitoring of patients with IBD, patient engagement and early treatment adjustments are still difficult hurdles. E-Health could be an efficient tool to improve these aspects, but the current evidence for its use in IBD is poor. An integrated cost-effective e-health system supported by a stable legal framework is eagerly needed.

Full Text | PDF

Comment: XIVth Little Brain Big Brain: next-generation enteric neuroscience
Arthur Beyder, Guillaume de Lartigue, Jean-Eric Ghia & Jill M. Hoffman
Published online: 05 January 2017
p135 | doi:10.1038/nrgastro.2016.199

Abstract | Full Text | PDF


Infection: Modifying recurrence of Clostridium difficile infection
Published online: 08 February 2017
p137 | doi:10.1038/nrgastro.2017.17


Obesity: Mechanisms behind reduced appetite for fat after gastric bypass uncovered
Published online: 25 January 2017
p138 | doi:10.1038/nrgastro.2017.8


Pancreatic cancer: PDAC metastases show identical known driver gene mutations
Published online: 25 January 2017
p138 | doi:10.1038/nrgastro.2017.9


IBS: The power of protease activity in IBS
Published online: 01 February 2017
p139 | doi:10.1038/nrgastro.2017.14


Liver: Spatial division of hepatic metabolic labour
Published online: 15 February 2017
p139 | doi:10.1038/nrgastro.2017.19


Nature Reviews Gastroenterology & Hepatology
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Liver cancer: Regorafenib as second-line therapy in hepatocellular carcinoma
Austin G. Duffy & Tim F. Greten
Published online: 08 February 2017
p141 | doi:10.1038/nrgastro.2017.7
Drug development in hepatocellular carcinoma had essentially stalled since 2008 when sorafenib was established as the modest standard of care. Now, a positive result in a phase III study evaluating regorafenib challenges us to weigh its clinical significance as well as its real-world benefits and potential harms.
Full Text | PDF

The mucosal immune system: master regulator of bidirectional gut-brain communications
Nick Powell, Marjorie M. Walker & Nicholas J. Talley
Published online: 18 January 2017
p143 | doi:10.1038/nrgastro.2016.191
Bidirectional gut-brain communications are proving key to both gastrointestinal and neurological diseases. This Review explores the role of the mucosal immune system as gatekeeper and master regulator of these brain–gut and gut–brain communications.
Abstract | Full Text | PDF

Bariatric surgery for obesity and metabolic disorders: state of the art
Ninh T. Nguyen & J. Esteban Varela
Published online: 30 November 2016
p160 | doi:10.1038/nrgastro.2016.170
Obesity is a major public health problem worldwide, and bariatric surgery offers an effective option for treatment of obesity and related comorbidities. Here, Nguyen and Varela discuss the indications, safety and outcomes of different bariatric operations in obesity and related metabolic disorders, such as type 2 diabetes mellitus, and examine emerging surgical treatment options.
Abstract | Full Text | PDF

Autophagy in the liver: functions in health and disease
Takashi Ueno & Masaaki Komatsu
Published online: 05 January 2017
p170 | doi:10.1038/nrgastro.2016.185
Autophagy is a conserved process critically involved in many cellular functions. In this Review, Ueno and Komatsu discuss the role and regulation of autophagy in healthy liver and in hepatic disease states, including NAFLD, α1-antitrypsin deficiency and viral hepatitis.
Abstract | Full Text | PDF

Gastrointestinal aspects of vasculitides
Medha Soowamber, Adam V. Weizman & Christian Pagnoux
Published online: 23 November 2016
p185 | doi:10.1038/nrgastro.2016.179
Systemic vasculitides can involve the gastrointestinal tract, hepatic system and pancreas, causing a range of gastrointestinal manifestations. In this Review, the authors summarize the epidemiology, gastrointestinal manifestations and management of systemic vasculitides as well as single-organ vasculitides in the gastrointestinal tract.
Abstract | Full Text | PDF

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