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Scientific Reports Health Sciences Table of Contents e-alert: 31 January 2017

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Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MS


Kang-Yi Su, Bo-Shiun Yan, Hao-Chieh Chiu et al.


The increasing incidence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB) adds further urgency for rapid and multiplex molecular …


Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity


Minah Kim, Tak Hyung Lee, Jung-Seok Choi et al.


Although internet gaming disorder (IGD) and obsessive-compulsive disorder (OCD) represent opposite ends of the impulsivity and compulsivity dimensions, the two disorders share …


IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis


Michelle S. M. A. Damen, Rabia Agca, Suzanne Holewijn et al.


Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the …


Does von Willebrand factor improve the predictive ability of current risk stratification scores in patients with atrial fibrillation?


Amaya García-Fernández, Vanessa Roldán, José Miguel Rivera-Caravaca et al.


Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined …


Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China


Bin Liu, Jingxian Ni, Min Shi et al.


Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. However, risk factors associated with CIMT remain unclear. Therefore, we …


Impact of small vessel disease in the brain on gait and balance


Daniela Pinter, Stuart J. Ritchie, Fergus Doubal et al.


Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain …


Treatment Outcomes of Patients with Locally Advanced Synchronous Esophageal and Head/Neck Squamous Cell Carcinoma Receiving Curative Concurrent Chemoradiotherapy


Yen-Hao Chen, Hung-I. Lu, Chih-Yen Chien et al.


The present study investigated clinical outcomes and prognostic factors of patients with locally advanced synchronous esophageal squamous cell carcinoma (ESCC) and head/neck …


A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance


Hee Seung Lee, Soo Been Park, Sun A Kim et al.


Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to …


Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats


Darya V. Telegina, Oyuna S. Kozhevnikova, Sergey I. Bayborodin et al.


Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events of AMD is poorly understood. It is …


N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis


Zhaohua Geng, Lan Huang, Mingbao Song et al.


The prognostic role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the general population remains controversial. We conducted this meta-analysis to investigate the …


Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment


Yugo Kai, Hayato Hikita, Naoki Morishita et al.


Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been …


Bacterial translocation aggravates CCl4-induced liver cirrhosis by regulating CD4+ T cells in rats


Haiyan Shi, Longxian Lv, Hongcui Cao et al.


Bacterial translocation (BT) is thought to play an important role in the development of liver cirrhosis, but the mechanisms have not been fully explored. This study aims to …


Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies


Bo Zhu, Xiaomei Wu, Yifei Bi et al.


Diabetes can affect many parts of the body and is associated with serious complications. Oxidative stress is a major contributor in the pathogenesis of diabetic complications and …


Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto’s thyroiditis: a meta-analysis


Xiaofei Wang, Wenli Cheng, Yu Ma et al.


Four VD receptor (VDR) gene polymorphisms (TaqI, ApaI, FokI and BsmI) have been reported to influence Hashimoto’s thyroiditis (HT) risk. However, individual studies have produced …


Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis


Zuyun Liu, Stephen Burgess, Zhengdong Wang et al.


Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the …


Risk factors of acute kidney injury after orthotopic liver transplantation in China


Yin Zongyi, Li Baifeng, Zou Funian et al.


In this study, we determined the risk factors for acute kidney injury (AKI) following orthotopic liver transplantation (OLT) in China. We collected 5074 donation after cardiac …


Prevalence and Predictors of Atherogenic Serum Lipoprotein Dyslipidemia in Women with Obstructive Sleep Apnea


Yunyan Xia, Yiqun Fu, Yuyu Wang et al.


Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, no study has focused on dyslipidemia in women with OSA. The aim of this study was to determine the …


CD133+ cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma


Kai Liu, Meijun Hao, Yabo Ouyang et al.


The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a …


Establishment and application of a novel isothermal amplification assay for rapid detection of chloroquine resistance (K76T) in Plasmodium falciparum


Madhvi Chahar, Neelima Mishra, Anup Anvikar et al.


Chloroquine (CQ) resistance in Plasmodium falciparum is determined by the mutations in the chloroquine resistance transporter (Pfcrt) gene. The point mutation at codon 76 (K76T), …


Stress Reactivity in Chronic Tinnitus


Linda T. Betz, Andreas Mühlberger, Berthold Langguth et al.


Tinnitus is primarily an auditory symptom. Yet not only patients and clinicians, but also current pathophysiological models relate the onset and maintenance of tinnitus to …


A glasses-type wearable device for monitoring the patterns of food intake and facial activity


Jungman Chung, Jungmin Chung, Wonjun Oh et al.


Here we present a new method for automatic and objective monitoring of ingestive behaviors in comparison with other facial activities through load cells embedded in a pair of …


A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency


Arun Kumar Tharkeshwar, Jesse Trekker, Wendy Vermeire et al.


Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle …


Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling


Hongwei Guo, Hua Luo, Hebao Yuan et al.


Litchi (Litchi chinensisSonnnerat, Sapindaceae), known as Chinese Cherry, is a subtropical fruit tree originating from southern China. Litchi seed extracts have diverse …


A UK wide cohort study describing management and outcomes for infants with surgical Necrotising Enterocolitis


Benjamin Allin, Anna-May Long, Amit Gupta et al.


The Royal College of Surgeons have proposed using outcomes from necrotising enterocolitis (NEC) surgery for revalidation of neonatal surgeons. The aim of this study was therefore …


Neutrophil gelatinase-associated lipocalin (NGAL) fails as an early predictor of contrast induced nephropathy in chronic kidney disease (ANTI-CI-AKI study)


Werner Ribitsch, Gernot Schilcher, Franz Quehenberger et al.


The aim of the study was to evaluate the diagnostic accuracy of urinary neutrophil gelatinase- associated lipocalin (uNGAL) in patients with chronic kidney disease (CKD) as an …


Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress


Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner et al.


Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) …


Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis


Michael Haimerl, Kirsten Utpatel, Niklas Verloh et al.


Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions and has …


Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations


Yue-miao Zhang, Xu-jie Zhou, Swapan K. Nath et al.


Ten novel loci have been found to be associated with systemic lupus erythematosus (SLE) susceptibility by a recent genome-wide association study conducted in Europeans. To test …


Effects of Single-Dose Prucalopride on Intestinal Hypomotility in Horses: Preliminary Observations


Fulvio Laus, Margherita Fratini, Emanuele Paggi et al.


Abnormalities of gastrointestinal motility are often a challenge in horses; however, the use of prokinetic drugs in such conditions must be firmly established yet. For this …


Comorbid diseases as risk factors for incident posttraumatic stress disorder (PTSD) in a large community cohort (KCIS no.PSY4)


Jung-Chen Chang, Amy Ming-Fang Yen, Hsiu-Hsi Chen et al.


Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and …


Six-year changes in the prevalence of obesity and obesity-related diseases in Northeastern China from 2007 to 2013


Jing Wu, Hongqin Xu, Xiuting He et al.


Obesity and obesity-related diseases are important public health challenges. In this study, we aimed to provide updated trends in the prevalence of these conditions. We conducted …


Association between underweight and tooth loss among Korean adults


In-Seok Song, Kyungdo Han, Jae-Jun Ryu et al.


There is growing interest in the relationship between body mass index and oral health. Previous study showed that being underweight was significantly associated with having lower …


Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis


Quan Fang, Songxue Guo, Hanlei Zhou et al.


Burn-wound progression can occur in the initial or peri-burn area after a deep burn injury. The stasis zone has a higher risk of deterioration mediated by multiple factors but is …


Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis


Jin Liu, Changwei Lu, Xiaohao Wu et al.


The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly …


Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart


Anne Van Steenbergen, Magali Balteau, Audrey Ginion et al.


Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose …


Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study


Miska Sulkava, Emma Raitoharju, Mari Levula et al.


Cardiovascular diseases due to atherosclerosis are the leading cause of death globally. We aimed to investigate the potentially altered gene and pathway expression in advanced …


Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro


Jian Wen, Yongbin Wu, Wei Wei et al.


Alcoholic liver disease (ALD) is an important worldwide public health issue with no satisfying treatment available since now. Here we explore the effects of recombinant human …


Preprocedural C-Reactive Protein Predicts Outcomes after Primary Percutaneous Coronary Intervention in Patients with ST-elevation Myocardial Infarction a systematic meta-analysis


Raluca-Ileana Mincu, Rolf Alexander Jánosi, Dragos Vinereanu et al.


Risk assessment in patients with acute coronary syndromes (ACS) is critical in order to provide adequate treatment. We performed a systematic meta-analysis to assess the …


Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis


Nan Li, Guang-Wei Tian, Ying Wang et al.


The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the …


Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21


Lili Ren, Donghong Yang, Xianwen Ren et al.


Human rhinovirus (HRV) is an important causative agent of acute respiratory tract infections (ARTIs). The roles of specific HRV genotypes in patients suffering from ARTIs have …


Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study


Tingting Qin, Wenhua Liu, Minghui Yin et al.


The present study aimed to investigate the role of abnormal body mass index (BMI, kg/m2) in the depression-CRP (C-reactive protein) relationship in a healthy middle-aged and …


LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974


Jaewoong Jang, Yoonju Jung, Youngeun Kim et al.


In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by …


Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells


Bhranti S. Shah, Mo Chen, Takahiro Suzuki et al.


Focal adipose deficiency, such as lipoatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet scarcely investigated in experimental …


A de novo deletion mutation in SOX10 in a Chinese family with Waardenburg syndrome type 4


Xiong Wang, Yaowu Zhu, Na Shen et al.


Waardenburg syndrome type 4 (WS4) or Waardenburg-Shah syndrome is a rare genetic disorder with a prevalence of <1/1,000,000 and characterized by the association of congenital …


Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways


Wei Feng, Hongrui Liu, Tingting Luo et al.


Interleukin (IL)-6 is known to indirectly enhance osteoclast formation by promoting receptor activator of nuclear factor kappa-B ligand (RANKL) production by osteoblastic/stromal …


Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro


Wei Yi, Jingjing Shi, Guanguan Zhao et al.


Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but …


Mastoid vibration affects dynamic postural control during gait in healthy older adults


Jung Hung Chien, Mukul Mukherjee, Jenny Kent et al.


Vestibular disorders are difficult to diagnose early due to the lack of a systematic assessment. Our previous work has developed a reliable experimental design and the result …


RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP


Tsung-Yuan Tsai, Wei-Ting Wang, Hao-Kang Li et al.


Multifunctional RNA helicase DDX3 participates in HCV infection, one of the major causes of hepatic steatosis. Here, we investigated the role of DDX3 in hepatic lipid metabolism. …


Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication


Kjersti M. Aagaard, Anismrita Lahon, Melissa A. Suter et al.


Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic …


Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway


Jialin Duan, Yue Guan, Fei Mu et al.


Hyperglycemia-induced reactive oxygen species (ROS) generation contributes to development of diabetic cardiomyopathy (DCM). This study was designed to determine the effect of an …


Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice


Zhi-Bin Wang, Ping Han, Ling-Chang Tong et al.


Susceptibility to motion sickness (MS) varies considerably among humans. However, the cause of such variation is unclear. Here, we used a classical genetic approach to obtain …


Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression


Mina G. Nashed, Robert G. Ungard, Kimberly Young et al.


Despite the lack of robust evidence of effectiveness, current treatment options for cancer-induced depression (CID) are limited to those developed for non-cancer related …


Genotype-phenotype relationship in patients with arrhythmogenic right ventricular cardiomyopathy caused by desmosomal gene mutations: A systematic review and meta-analysis


Zhenyan Xu, Wengen Zhu, Cen Wang et al.


The relationship between clinical phenotypes and desmosomal gene mutations in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is poorly characterized. …


Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer


Xiong Li, Kecheng Huang, Qinghua Zhang et al.


To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association …


Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor


César S. Huertas, Santos Domínguez-Zotes, Laura M. Lechuga


Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects …


The role of miR-26a and miR-30b in HER2+ breast cancer trastuzumab resistance and regulation of the CCNE2 gene


Eduardo Tormo, Anna Adam-Artigues, Sandra Ballester et al.


A subset of HER2+ breast cancer patients manifest clinical resistance to trastuzumab. Recently, miR-26a and miR-30b have been identified as trastuzumab response regulators, and …


Associations of maternal pre-pregnancy body mass index and gestational weight gain with birth outcomes in Shanghai, China


Lingli Xiao, Guodong Ding, Angela Vinturache et al.


Recent data suggests that abnormal maternal pre-pregnancy body mass index (BMI) or gestational weight gain (GWG) is associated with unfavorable delivery outcomes. However, …


Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans


Chui Ming Gemmy Cheung, Augustinus Laude, Ian Yeo et al.


To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further …


Relationship between bony tunnel and knee function in patients after patellar dislocation triple surgeries—a CT-based study


Le Qin, Mei Li, Weiwu Yao et al.


We aimed to assess the CT-based bony tunnel valuations and their correlation with knee function after patellar dislocation triple surgeries. A retrospective study was performed …


Physical Activity, TV Watching Time, Sleeping, and Risk of Obesity and Hyperglycemia in the Offspring of Mothers with Gestational Diabetes Mellitus


Tao Zhang, Peng Wang, Huikun Liu et al.


We investigated the association of physical activity, TV watching time, sleeping time with the risks of obesity and hyperglycemia among 1263 offspring aged 1–5 years of mothers …


Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling


Liming Yu, Bing Gong, Weixun Duan et al.


Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial …


Genomic structural variations for cardiovascular and metabolic comorbidity


Maria S. Nazarenko, Aleksei A. Sleptcov, Igor N. Lebedev et al.


The objective of this study was to identify genes targeted by both copy number and copy-neutral changes in the right coronary arteries in the area of advanced atherosclerotic …


Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations


Shuquan Rao, Yao Yao, Joanne Ryan et al.


Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether


Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells


Zohreh Hosseinzadeh, Yogesh Singh, Derya R. Shimshek et al.


Leucine-rich repeat kinase 2 (Lrrk2) has been implicated in the pathophysiology of Parkinson’s disease. Lrrk2 is expressed in diverse cells including neurons and dendritic cells …


Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity


Yukti Choudhury, Yi Chin Toh, Jiangwa Xing et al.


Idiosyncratic drug-induced hepatotoxicity is a major cause of liver damage and drug pipeline failure, and is difficult to study as patient-specific features are not readily …


The Role of Vascular Endothelial Growth Factor in Small-airway Remodelling in a Rat Model of Chronic Obstructive Pulmonary Disease


Lu Wang, Zhibo Xu, Bin Chen et al.


Small-airway remodelling is one of the most remarkable pathological features of chronic obstructive pulmonary disease (COPD), in which angiogenesis plays a critical role that …


Safety and Efficacy of Single-Stage Surgical Treatment for Congenital Scoliosis Associated with Intraspinal Mass


Bo-bo Zhang, Hui-ren Tao, Tai-lin Wu et al.


For congenital scoliosis associated with intraspinal anomaly, surgical treatment is often advocated. However, the safety and efficacy of single-stage intraspinal mass resection …


Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese


Ching-Lung Cheung, Daniel Ka-Chun Ho, Chor-Wing Sing et al.


Phytosterols found naturally in plants are known to reduce cholesterol absorption in the gut. The traditional southern Chinese diet typically contains many vegetables and not …


Albuminuria is an independent risk factor of T4 elevation in chronic kidney disease


Xin Du, Binbin Pan, Wenwen Li et al.


This study was to explore the association between thyroid dysfunction and albuminuria. 581 cases with chronic kidney disease (CKD) were included in this study. The clinical …


Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib


Arancha Cebrián, Teresa Gómez del Pulgar, María José Méndez-Vidal et al.


Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but …


SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma


Yanzhang Luo, Tin Seak Mok, Xiuxian Lin et al.


Nasopharyngeal carcinoma (NPC) is a serious threat to public health, and the biomarker discovery is of urgent needs. The data-independent mode (DIA) based sequential window …


ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling


Xiaoming Li, Fei Wang, Min Xu et al.


Insulin resistance is a risk factor for type 2 diabetes mellitus. We investigated the effect of ApoA-IV on glucose uptake in the adipose and muscle tissues of mice and cultured …


Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay


Wim Trypsteen, Pejman Mohammadi, Clarissa Van Hecke et al.



Utility of baseline, interim and end-of-treatment 18F-FDG PET/CT in extranodal natural killer/T-cell lymphoma patients treated with L-asparaginase/pegaspargase


Yu Chang, Xiaorui Fu, Zhenchang Sun et al.


Positron emission tomography-computed tomography (PET/CT) is widely used for initial staging and monitoring treatment responses in Hodgkin and diffuse large B-cell lymphoma. …


Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish


Yan Li, Hankun Li, Jan M. Spitsbergen et al.


Hepatocellular carcinoma (HCC) is more prevalent in men than women, but the reason for this gender disparity is not well understood. To investigate whether zebrafish could be …


Highly Sensitive Marker Panel for Guidance in Lung Cancer Rapid Diagnostic Units


Sonia Blanco-Prieto, Loretta De Chiara, Mar Rodríguez-Girondo et al.


While evidence for lung cancer screening implementation in Europe is awaited, Rapid Diagnostic Units have been established in many hospitals to accelerate the early diagnosis of …


Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease


Cynthia Sandor, Frantisek Honti, Wilfried Haerty et al.


Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, affecting 1% of the population over 65 years characterized clinically by both motor and non-motor …


Biological Membrane-Packed Mesenchymal Stem Cells Treat Acute Kidney Disease by Ameliorating Mitochondrial-Related Apoptosis


Xiaodong Geng, Quan Hong, Weiwei Wang et al.


The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. The aim of this study was to …


IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide


Wei Zhong, Ling Zhao, Tao Liu et al.


T cells are key players in immune-mediated rheumatoid arthritis (RA). We previously reported that interleukin (IL)-22+CD4+T helper (IL-22+ Th) cells and IL-22 critically control …


Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation


Michela Masè, Margherita Grasso, Laura Avogaro et al.


MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). Reverse …


Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium


Hanlu Fan, Xiaohong Du, Jingyuan Zhang et al.


The Ebola crisis occurred in West-Africa highlights the urgency for its clinical treatments. Currently, no Food and Drug Administration (FDA)-approved therapeutics are available. …


Treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease


Ai-Ho Liao, Chi-Ray Hung, Chieh-Fu Lin et al.


Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered …


A 10-year observation of PM2.5-bound nickel in Xi’an, China: Effects of source control on its trend and associated health risks


Hongmei Xu, Steven Sai Hang Ho, Junji Cao et al.


This study presents the first long term (10-year period, 2004–2013) datasets of PM2.5-bound nickel (Ni) concentration obtained from the daily sample in urban of Xi’an, …


A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk


Rachel J. J. Elands, Colinda C. J. M. Simons, Mona Riemenschneider et al.


Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. …


Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis


Sabrina Cipriani, Adriana Carino, Dario Masullo et al.


The small heterodimer partner (SHP) is an orphan nuclear receptor that lacks the DNA binding domain while conserves a putative ligand-binding site, thought that endogenous …


Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis


Tobias V. Lanz, Sarah K. Williams, Aleksandar Stojic et al.


The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is …


Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells


Nami Kim, Miso Nam, Mi Sun Kang et al.


This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using 1H-NMR-based metabolome …


A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding


Juan A. González-Vera, Rocío A. Medina, Mar Martín-Fontecha et al.


Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these …


Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes


Carmelo Milioto, Adriana Malena, Eleonora Maino et al.


Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in …

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