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vrijdag 19 oktober 2018

RCOA: FPM Position Statement on the medicinal use of cannabinoids in Pain Medicine

FPM Position Statement on the medicinal use of cannabinoids in Pain Medicine

The Faculty has released a position statement on the use of cannabis derived medicinal products in relation to Pain Medicine.  The statement can be accessed here.

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Liverpool hospitals recognised for high quality patient care

Anaesthetists at two Liverpool hospitals have been recognised for providing the highest quality care to local patients.

The anaesthetic departments at Alder Hey Children's Hospital and Aintree University Hospital received the prestigious Anaesthesia Clinical Services Accreditation (ACSA) from the Royal College of Anaesthetists (RCoA) at separate ceremonies on 18 October.

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Scientific reports: Monomerization of the photoconvertible fluorescent protein SAASoti by rational mutagenesis of sin...

Monomerization of the photoconvertible fluorescent protein SAASoti by rational mutagenesis of single amino acids
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Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients
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Comparative venom-gland transcriptomics and venom proteomics of four Sidewinder Rattlesnake (Crotalus cerastes) lineages reveal little differential expression despite individual variation
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A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme
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Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice
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Bispectrum Features and Multilayer Perceptron Classifier to Enhance Seizure Prediction
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In-depth study on resonant tunneling for subwavelength imaging
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NHS Confederation: Revealed: The reality behind the 2019–24 NHS funding settlement

Revealed: The reality behind the 2019–24 NHS funding settlement
New infographic explores reality of the NHS' five-year funding settlement , what it will mean in practice and what we need to deliver it.
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Encouraging to hear Secretary of State's support for shifting balance of services, says Community Network in response to NAPC speech
Matthew Winn, chair of the Community Network, responds to the health secretary's speech
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This is a moment we can decide to do better, says NHS Confederation in response to Secretary of State's speech at NAPC conference
Niall Dickson, chief executive of the NHS Confederation, responds to the health secretary's speech at the NAPC conference
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Scientific reports: A Microfluidic Device for Simultaneous Extraction of Plasma, Red Blood Cells, and On-Chip White B...

A Microfluidic Device for Simultaneous Extraction of Plasma, Red Blood Cells, and On-Chip White Blood Cell Trapping
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Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China
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Novel biconvex structure electrowetting liquid lenticular lens for 2D/3D convertible display
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Author Correction: Toxicity evaluation of Wanzhou watershed of Yangtze Three Gorges Reservoir in the flood season in Caenorhabditis elegans
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From monetite plate to hydroxyapatite nanofibers by monoethanolamine assisted hydrothermal approach
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Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
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Author Correction: Direct RNA Sequencing of the Coding Complete Influenza A Virus Genome
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Costing newsletter: 11 October 2018

Costing newsletter: 11 October 2018
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Financial improvement at Maidstone and Tunbridge Wells NHS Trust
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Chair, Norfolk and Suffolk NHS Foundation Trust
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Nature Reviews Neuroscience contents November 2018 Volume 19 Number 11

Nature Reviews Neuroscience


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Focal Point on Kobe 

A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub
TABLE OF CONTENTS

November 2018 Volume 19, Issue 11

Research Highlights
Reviews
Perspectives

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Imagine what you can do with a 360° view of locomotion A key endpoint to evaluate efficacy of Parkinson's disease therapies is changes in movement and balance. Typically, these endpoints are measured using established methods like rotarod tests that detect overt changes. At Charles River, we have developed a quantitative fine motor kinematics method to measure small changes in locomotor activity in rodent models of Parkinson's disease to develop a movement "signature".
 
 



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Astrocyte Development & Function Poster

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Research Highlights

Rewarding gut feeling
Sian Lewis
p639 | doi:10.1038/s41583-018-0075-3
Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.
PDF



In or out of synch
Natasha Bray
pp640 - 641 | doi:10.1038/s41583-018-0074-4
In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.
PDF



It's about time
Katherine Whalley
pp640 - 641 | doi:10.1038/s41583-018-0066-4
Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.
PDF



Incidental associations
Sian Lewis
p641 | doi:10.1038/s41583-018-0069-1
Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour.
PDF



A position on vision
Darran Yates
p642 | doi:10.1038/s41583-018-0076-2
PDF



Number crunching
Katherine Whalley
p642 | doi:10.1038/s41583-018-0073-5
Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe
PDF



Nature Reviews Neuroscience
EVENT
Neurodegenerative Diseases: Biology & Therapeutics
28.11.18
Cold Spring Harbor, USA
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Reviews

The neural mechanisms and circuitry of the pair bond   
Hasse Walum & Larry J. Young
pp643 - 654 | doi:10.1038/s41583-018-0072-6
Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love.
Full Text | PDF



CNS infection and immune privilege   
John V. Forrester, Paul G. McMenamin & Samantha J. Dando
pp655 - 671 | doi:10.1038/s41583-018-0070-8
Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections.
Full Text | PDF



Imaging-based parcellations of the human brain   
Simon B. Eickhoff, B. T. Thomas Yeo & Sarah Genon
pp672 - 686 | doi:10.1038/s41583-018-0071-7
The brain can be parcellated into areas or networks with different structural or functional properties. Eickhoff, Yeo and Genon describe various imaging-based strategies to parcellate the human brain, including those based on local properties, such as cytoarchitecture, and global properties, such as connectivity.
Full Text | PDF



Imaging the evolution and pathophysiology of Alzheimer disease   
William Jagust
pp687 - 700 | doi:10.1038/s41583-018-0067-3
Various techniques can be used to image aspects of the pathophysiology of Alzheimer disease in humans, notably protein deposition and neurodegeneration. In this Review, William Jagust discusses how human neuroimaging studies have shaped our understanding of this disease.
Full Text | PDF



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Perspectives

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing   
Roberto Cabeza, Marilyn Albert, Sylvie Belleville, Fergus I. M. Craik, Audrey Duarte et al.
pp701 - 710 | doi:10.1038/s41583-018-0068-2
Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve.
Full Text | PDF



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Alzheimer's Disease Therapeutics: Alternatives to Amyloid

December 11, 2018, NYC

Featuring Rudolph Tanzi, PhD, of Harvard Medical School, this symposium will highlight non-amyloid mechanisms driving Alzheimer's disease including mitochondrial factors, the vasculature, and autophagy, and discuss strategies to identify new therapeutic targets. Abstracts Nov 2.

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