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woensdag 10 januari 2018

Nature Biotechnology Contents: Volume 36 pp 1 - 116

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GTEx Collection

Nature Research is pleased to present this Collection of Commentary, News and Research from across the Nature journals for the second phase of the GTEx project. 

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TABLE OF CONTENTS

January 2018 Volume 36, Issue 1

Editorial
News
News Feature
Opinion and Comment
Feature
News and Views
Research
Careers and Recruitment

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Editorial

Aligning stars of all colors    p1
doi:10.1038/nbt.4050

News

Drugmakers cling to dual IL-13/IL-4 blockbuster hopes    pp3 - 5
Cormac Sheridan
doi:10.1038/nbt0118-3

AI for your heart, on your wrist    p5
doi:10.1038/nbt0118-5a

First in vivo human genome editing trial    p5
doi:10.1038/nbt0118-5b

FDA approves hereditary blindness gene therapy    p6
doi:10.1038/nbt0118-6a

With a free pass, CRISPR-edited plants reach market in record time    pp6 - 7
Emily Waltz
doi:10.1038/nbt0118-6b

China's fledgling biotech sector fizzes into life    pp8 - 9
Shannon Ellis
doi:10.1038/nbt0118-8

FDA to relax grip on at-home genetic tests, but concerns linger    pp10 - 11
Mark Ratner
doi:10.1038/nbt0118-10

PODCAST: First rounders: Susan Windham-Bannister    p11
doi:10.1038/nbt.4053

Bluebird's BCMA CAR-T impresses at ASH    p11
doi:10.1038/nbt0118-11

Texas displays 'Silicon Valley' credentials to lure Brazilian biotechs    pp12 - 13
Melanie Senior
doi:10.1038/nbt0118-12

Around the world in a month    p13
doi:10.1038/nbt0118-13

News Feature

DNA makes an appearance    pp14 - 17
Laura DeFrancesco
doi:10.1038/nbt.4057

An online-only, open access journal publishing high-quality original papers and review articles relevant to all aspects of digital medicine and health, npj Digital Medicine has now published its first articles. Part of the Nature Partner Journals series, npj Digital Medicine is published in partnership with the Scripps Translational Science Institute.
 

Opinion and Comment

Correspondence

Why the European Union needs a national GMO opt-in mechanism    pp18 - 19
Dennis Eriksson, Eugénia de Andrade, Borut Bohanec, Sevasti Chatzopolou, Roberto Defez et al.
doi:10.1038/nbt.4051

Feature

Biotech's pale shadow    pp20 - 30
Brady Huggett
doi:10.1038/nbt.4046

Patents

Mapping the global influence of published research on industry and innovation    pp31 - 39
Osmat A Jefferson, Adam Jaffe, Doug Ashton, Ben Warren, Deniz Koellhofer et al.
doi:10.1038/nbt.4049

Recent patents in proteomics    p40
doi:10.1038/nbt.4064

npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines.npj Vaccines is now open for submissions.
 
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News and Views

Strength in numbers from integrated single-cell neuroscience    pp41 - 42
Rahul Satija
doi:10.1038/nbt.4055

Viruses leave their stamp on single cells    pp42 - 44
Ede A Rancz & Andreas T Schaefer
doi:10.1038/nbt.4043

RNA-targeting CRISPR comes of age    pp44 - 45
V Narry Kim
doi:10.1038/nbt.4054

Research Highlights    p45
doi:10.1038/nbt.4058

Biotechnology
JOBS of the week
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Recruitment for Academic Positions
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Experimental (wet-lab) postdoctoral position in proteomics at Cornell University
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Research

Review

Precision oncology in the age of integrative genomics    pp46 - 60
Chandan Kumar-Sinha & Arul M Chinnaiyan
doi:10.1038/nbt.4017
Chandan Kumar-Sinha and Arul Chinnaiyan summarize the increasing use of sequencing panels to screen for cancer-associated genes in tumor and germline samples. The authors highlight the increasing appreciation of aberrations in regulatory genes or chromatin-related genes and argue that precision oncology must be considered in the context of adding value to the standard of care, not apart from it.

Articles

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation    pp61 - 69
John Beaulaurier, Shijia Zhu, Gintaras Deikus, Ilaria Mogno, Xue-Song Zhang et al.
doi:10.1038/nbt.4037
Similar bacterial species and strains in metagenomes are resolved and linked to the plasmids that they harbor using DNA methylation analysis.

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain    pp70 - 80
Blue B Lake, Song Chen, Brandon C Sos, Jean Fan, Gwendolyn E Kaeser et al.
doi:10.1038/nbt.4038
Single-cell analysis of the adult human brain is facilitated by improved methods for RNA-seq and hypersensitive-site mapping.

Virus stamping for targeted single-cell infection in vitro and in vivo    pp81 - 88
Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan et al.
doi:10.1038/nbt.4034
Viruses are transduced to single cells in tissues, organoids and in the mouse brain using mechanical carriers.

Multiplexed droplet single-cell RNA-sequencing using natural genetic variation    pp89 - 94
Hyun Min Kang, Meena Subramaniam, Sasha Targ, Michelle Nguyen, Lenka Maliskova et al.
doi:10.1038/nbt.4042
Droplet single-cell RNA-seq is applied to large numbers of pooled samples from unrelated individuals.

Letter

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency    pp95 - 102
Marella D Canny, Nathalie Moatti, Leo C K Wan, Amélie Fradet-Turcotte, Danielle Krasner et al.
doi:10.1038/nbt.4021
Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells.

Resources

Global landscape of cell envelope protein complexes in Escherichia coli    pp103 - 112
Mohan Babu, Cedoljub Bundalovic-Torma, Charles Calmettes, Sadhna Phanse, Qingzhou Zhang et al.
doi:10.1038/nbt.4024
A survey of cell envelope proteins and their interacting partners in E. coli by mass spectrometry reveals insights into essential bacterial processes.

Careers and Recruitment

Mentoring for diversity in technology    pp113 - 115
Maggie Werner-Washburne
doi:10.1038/nbt.4025

People

People    p116
doi:10.1038/nbt.4065

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