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vrijdag 1 december 2017

EMBO reports Table of Contents for December 2017; Vol. 18, No. 12

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December 2017 | Volume 18, Number 12 Submit


Table of Contents

Obituary
Opinion
Correspondence
Science & Society
Review
Scientific Reports
Articles
Corrigendum
COVER

Volume 18, Number 12



Obituary
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Anton Wutz
Published online 21.11.2017

Opinion
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Gold OA as a publishing model has created conflicts of interest for authors and journals that create a risk for research integrity. Alternative models of publishing and peer review could resolve some of these conflicts.

Ignacio Amigo and Alberto Pascual‐García
Published online 20.11.2017

Correspondence
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Comment on “The Council of Europe should not reaffirm the ban on germline genome editing in humans” by Sykora & Caplan.

Françoise Baylis and Lisa Ikemoto
Published online 15.11.2017

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The response by the authors.

Peter Sykora and Arthur Caplan
Published online 15.11.2017

Science & Society
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The growing importance of nucleotide sequence databases for research and the need for reproducibility necessitates that scientists should provide as much as experimental detail as possible when submitting sequence data to electronic archives.

Matheus Sanitá Lima and David Roy Smith
Published online 27.10.2017

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Environmental NGOs have various concerns about agricultural biotechnologies including gene editing. Accepting their skepticism of problems and solutions could help to build mutual understanding and find acceptable solutions to global food vulnerabilities.

Richard Helliwell, Sarah Hartley, Warren Pearce and Liz O'Neill
Published online 02.11.2017

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The invention of culture allowed mankind to create its own ecological niches. But does it mean that humans have stopped evolving biologically or are we still adapting to our artificial environment?

Andrea Rinaldi
Published online 21.11.2017

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Novel therapies, such as gene or cell therapy, don not require radical changes of the regulatory framework for medicinal products. Yet, both new and old developments cannot be easily accommodated by existing regulations.

Philip Hunter
Published online 09.11.2017

Review
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Cell fate decisions are mainly considered to be regulated via transcriptional programming, epigenetic modifications, and biochemical differentiation triggers. This review discusses how different cell biological cues acting upstream and downstream of developmental signaling pathways influence lineage determination.

Sumitra Tatapudy, Francesca Aloisio, Diane Barber and Todd Nystul
Published online 20.11.2017

Scientific Reports
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Whether EGFR is recycled or degraded is critical for growth signalling in cancer. The endocytic adaptor intersectin binds the Rab13 exchange factor DENND2B and drives unliganded EGFR into a recycling pathway, while EGF disrupts this interaction and targets EGFR for degradation.

Maria S Ioannou, Gopinath Kulasekaran, Maryam Fotouhi, Justin J Morein, Chanshuai Han, Sarah Tse, Nadya Nossova, Tony Han, Erin Mannard and Peter S McPherson
Published online 13.10.2017

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The histone demethylase JMJD5 cleaves the histone H3 N‐tail between K9me1 and S10 under DNA damaging stress. Cleavage occurs at gene promoters bound and repressed by JMJD5 suggesting a role in gene expression regulation.

Jing Shen, Xueping Xiang, Lihan Chen, Haiyi Wang, Li Wu, Yanyun Sun, Li Ma, Xiuting Gu, Hong Liu, Lishun Wang, Ying‐nian Yu, Jimin Shao, Chao Huang and Y Eugene Chin
Published online 05.10.2017

Articles
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Immunity to mycobacteria triggers granulomas, involving multinucleated giant cells as a unique macrophage species. Dysregulation of the TLR‐induced antimicrobial molecule nitric oxide propagates their transformation by interfering with the DNA damage response.

Kourosh Gharun, Julia Senges, Maximilian Seidl, Anne Lösslein, Julia Kolter, Florens Lohrmann, Manfred Fliegauf, Magdeldin Elgizouli, Martina Vavra, Kristina Schachtrup, Anna L Illert, Martine Gilleron, Carsten J Kirschning, Antigoni Triantafyllopoulou and Philipp Henneke
Published online 02.11.2017

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The MAVS signalosome mediates RIG‐I‐like receptor‐induced anti‐viral innate immune responses. NLRP11 inhibits MAVS‐dependent type I interferon signaling and virus‐induced apoptosis by disrupting the signalosome and promoting proteasomal degradation of TRAF6.

Yunfei Qin, Zexiong Su, Yaoxing Wu, Chenglei Wu, Shouheng Jin, Weihong Xie, Wei Jiang, Rongbin Zhou and Jun Cui
Published online 02.11.2017

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Glioblastoma cells excrete branched‐chain ketoacids (BCKAs) through the monocarboxylate transporter MCT1. BCKAs are taken up by macrophages and alter their metabolism and phagocytic capacity, possibly enhancing immune suppression in glioblastoma.

Lidia Santos Silva, Gernot Poschet, Yannic Nonnenmacher, Holger M Becker, Sean Sapcariu, Ann‐Christin Gaupel, Magdalena Schlotter, Yonghe Wu, Niclas Kneisel, Martina Seiffert, Rüdiger Hell, Karsten Hiller, Peter Lichter and Bernhard Radlwimmer
Published online 24.10.2017

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Antisense transcription from the same locus is required for DOG1 silencing in mature Arabidopsis plants under non‐stress conditions. Drought and ABA signalling alleviate asDOG1 expression, promoting DOG1 sense transcription and drought tolerance.

Ruslan Yatusevich, Halina Fedak, Arkadiusz Ciesielski, Katarzyna Krzyczmonik, Anna Kulik, Grazyna Dobrowolska and Szymon Swiezewski
Published online 13.10.2017

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The Schizosaccharomyces pombe SAGA co‐activator regulates gene expression and cell fate decisions in response to nutrient availability. This study shows that TORC1 and TORC2 modulate the phosphorylation of the SAGA subunit Taf12, to control commitment to sexual differentiation upon starvation.

Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez‐Mias, Céline Faux, Yves Romeo, Mirita Franz‐Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen and Dominique Helmlinger
Published online 27.10.2017

Corrigendum

 
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