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donderdag 2 november 2017

The Lancet: [Articles] Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have prog...

[Articles] Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial
The GOLD study did not meet its primary objective of showing a significant improvement in overall survival with olaparib in the overall or ATM-negative population of Asian patients with advanced gastric cancer. The study generated informative efficacy and safety data regarding the use of olaparib in combination with a chemotherapeutic agent and provides a foundation for future studies in this difficult-to-treat patient population.
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[Comment] Missing a GOLDen opportunity in gastric cancer
Advanced gastric cancer has a poor prognosis; currently available palliative treatments result in survival of less than 18 months for most patients. Although immune checkpoint blockade has shown promise in chemorefractory gastric cancer, the modest benefit associated with anti-PD-1 therapy means that alternative gastric cancer vulnerabilities should continue to be explored.1 Defective homologous recombination, classically found in BRCA-mutated tumours, has been successfully exploited by poly-ADP-ribose polymerase (PARP) inhibitors in ovarian, breast, and prostate cancer.
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[News] Thermography should not be used in breast cancer screening
Thermography should not be used as a substitute for mammography in either breast cancer screening or early-stage diagnosis, the US Food and Drug Administration (FDA) have warned.
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[News] Possible origin of ovarian cancer in the fallopian tubes
Less than 30% of patients with ovarian cancer survive beyond 10 years after diagnosis. To improve diagnosis and treatment, and therefore the chance of survival from ovarian cancer, its history and progression need to be fully understood. Findings from a recent US study suggest that the fallopian tubes are the site of origin for high-grade serous ovarian carcinomas (HGSOC).
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[News] Tobacco control in the UK
On Oct 25, 2017, a parliamentary inquiry into electronic cigarettes (e-cigarettes) was launched in the UK. The Science and Technology Committee will investigate the health effects of e-cigarettes, as well as their effectiveness as smoking cessation tools. Written submissions are invited on addiction to e-cigarettes, their use among young people, and their potential for renormalising smoking. An estimated 2·9 million people use e-cigarettes in the UK. John Britton (Nottingham University, Nottingham, UK) welcomed the inquiry.
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